This authoritative volume focuses on emerging technologies in
cancer nano medicine, characterized by their multi-functionality
and potential to address simultaneously diverse issues of clinical
relevance in the treatment of cancer. The book consists of sixteen
chapters divided into six sections: 1) Biological Barriers in
Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene
Therapy; 5) Nano theranostics and 6) Translational Aspects of
Nano-Oncologicals. The volume starts with an introduction
describing the biological barriers associated with cancer therapy
and highlighting ways to overcome such barriers through the use of
nanotechnology. This is followed by an analysis of the two major
targeting strategies currently under investigation in cancer
therapy: namely, the targeting of cancer cells and the targeting of
the immune system. In the first case, the book presents liposomal
and polymer-based therapies, including photodynamic approaches. In
the second case, it analyzes in detail the possibility of either
improving the efficiency of the immune system toward preventing
cancer progression (cancer immunomodulation) or generating
responses against specific cancer antigens (cancer vaccines).
Beyond these targeting options, "Nano-Oncologicals: New
Targeting and Delivery Approaches" presents the most recent
technological advances in the area of nucleic acid-based therapies,
along with those in the area of theranostics, where the design of
multifunctional nano carriers becomes vital. Following the study of
the most promising nanotechnologies around the development of
nano-oncologicals, the book ends with an overview of regulatory and
toxicological issues, which are critical in their translational
pathway, and the presentation of a nucleic acid-based therapy
case-study. This book is an important resource for scientists
interested in the design and development of anticancer
nanotechnologies and also to those aiming to push their technology
through clinical development.
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