The work described in this book is an excellent example of
interdisciplinary research in systems biology. It shows how
concepts and approaches from the field of physics can be
efficiently used to answer biological questions and reports on a
novel methodology involving creative computer-based analyses of
high-throughput biological data. Many of the findings described in
the book, which are the result of collaborations between the author
(a theoretical scientist) and experimental biologists and between
different laboratories, have been published in high-quality
peer-reviewed journals such as Molecular Cell and Nature. However,
while those publications address different aspects of
post-transcriptional gene regulation, this book provides readers
with a complete, coherent and logical view of the research project
as a whole. The introduction presents post-transcriptional gene
regulation from a distinct angle, highlighting aspects of
information theory and evolution and laying the groundwork for the
questions addressed in the subsequent chapters, which concern the
regulation of the transcriptome as the primary functional carrier
of active genetic information.
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