Bone is a dynamic tissue that undergoes continual adaptation during
vertebrate life to preserve skeletal size, shape, and structural
integrity and to regulate mineral homeostasis. Bone mass is
skilfully regulated through osteoclasts and osteoblasts. Bone mass
is reduced through decreased osteoblastic bone formation and
increased osteoclastic bone resorption. This decrease induces
osteoporosis. Bone loss is also caused in various pathophysiologic
states including inflammatory condition, obesity, diabetes, and
cancer cell bone metastasis. In addition, malnutrition or
undernutrition is often observed with increasing ages and is
strongly implicated in the pathogenesis and consequences of bone
fracture in the osteoporotic elderly. Nutritional and functional
food factors may play a pivotal role in maintaining bone health,
and this will be expected as a new biomedical treatment for
osteoporosis.
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