Targeted Molecular Imaging covers the development of novel
diagnostic approaches that use an imaging probe and agent to
noninvasively visualize cellular processes in normal and disease
states. It discusses the concept, development, preclinical studies,
and, in many cases, translation to the clinic of targeted imaging
agents.
The many case studies that form the core of this book deal with
the development and translation of non-nuclear probes and
radiotracers; other sections address critical topics such as In
vitro studies, small animal research, and the application of
targeted probes for nuclear, optical and MRI imaging. The chapters
use a common format to demonstrate how various investigators
approach the comprehensive task of validating a new targeted
probe.
Targeted Molecular Imaging is a timely resource for a rapidly
advancing field, and addresses:
- Various methods of validating a new targeted probe through
examples from human studies with imaging of breast cancer,
cardiovascular disease, and neurodegenerative diseases
- Basic principles, disease models, imaging studies in animals,
imaging in initial human studies, and the application of molecular
imaging in pharmacy and drug discovery
- In vitro studies, small animal studies, and targeted
radiopharmaceuticals
Using these case studies, investigators can generalize and apply
the information to their own specific targeted probe. The insights
provided by the contributors, experts who have developed these
approaches in their own groups, help guide scientists planning to
translate imaging agents from the concept stage to clinical
application.
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