Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more.

Imaging Methodology and Applications in Parkinson's Disease, Volume 141, provides an up-to-date and comprehensive textbook on the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools has played a pivotal role in expanding our understanding of disease etiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis, and in the identification of novel targets for therapeutic intervention. This book brings together lessons learned from neuroimaging tools in movement disorders, including chapters on Advances in PET Methodology, Advances in MRI Methodology, Advances in SPECT Methodology, Hybrid PET/MRI Methodology, and more.

This issue of MRI Clinics of North America focuses on Imaging of the Foot and Ankle, and is edited by Dr. Mary Hochman. Articles will include: Technical Considerations: Best Practices for MR Imaging of the Foot and Ankle; Normal Variants and Potential Pitfalls in MRI of the Ankle and Foot; Medial Sided Ankle Pain: MRI of the Deltoid Ligament and Beyond; MRI of Impingement and Entrapment Syndromes of the Foot and Ankle; MRI of the Diabetic Foot; MRI of the Midfoot; MRI of the Plantar Plate: Normal Anatomy, Turf Toe, and other Injuries; MRI of Common Bone and Soft Tissue Tumors in the Foot and Ankle; MRI of the Post-operative Ankle and Foot; New Techniques in MR Imaging of the Ankle and Foot; MRI of the Pediatric Foot and Ankle: What Does Normal Look Like?; and more!

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

This issue of PET Clinics focuses on Special Techniques and Technical Advances in PET/CT Imaging. Articles will include: PET/CT Guided FNAC/Biopsy; Dual Time Point Imaging; Overview of Conventional imaging based intervention in clinical practice; Special Techniques in PET/CT in evaluating genito-urinary malignances; Special techniques in PET/CT imaging for evaluation of head and neck cancer; PET/CT enteroclysis; Contrast media in PET/CT imaging; PET/CT guided RFA; Non-attenuated corrected PET/CT imaging and applications; and more!

This issue of Neuroimaging Clinics of North America focuses on Plaque Imaging. Articles will include: 3D carotid plaque MR imaging, Analysis of multi-contrast carotid plaque MR imaging, Incorporating carotid plaque imaging into routine clinical carotid MRA, PET-CT imaging to assess future cardiovascular risk, Utility of combining PET and MR imaging of carotid plaque, 3D carotid plaque ultrasound, Contrast-enhanced carotid plaque ultrasound, Detection of vulnerable plaque in patients with "cryptogenic stroke," Measuring plaque burden in secondary prevention of asymptomatic patients with known carotid stenosis, Plaque imaging in primary prevention of cardiovascular disease, Plaque imaging to decide on optimal treatment: medical versus CEA versus CAS, Clinical perspective of carotid plaque imaging, and more!

MRI of the Elbow and Wrist is explored in this important issue in MRI Clinics of North America. Articles include: Approach to MRI of the Elbow and Wrist: Technical Aspects and Innovation; MRI of the Elbow; Extrinsic and Intrinsic Ligaments of the Wrist; MRI of the Triangular Fibrocartilage Complex; Carpal Fractures; MRI of Tumors of the Upper Extremity; MRI of the Nerves of the Upper Extremity: Elbow to Wrist; MR Arthrography of the Wrist and Elbow; MRI of the Wrist and Elbow: What the Hand Surgeon Needs to Know; Imaging the Proximal and Distal Radioulnar Joints; MR Angiography of the Upper Extremity, and more!

Editor Hersh Chandarana, MD and authors review Advanced MR Imaging in Clinical Practice. Articles will include: Current Status of Diffusion Weighted Imaging; Current Status of Perfusion Weighted Imaging; Non-gadolinium Enhanced MR Angiography; Pearls and Pitfalls of 3 T imaging; Implementing MR Neurography in Clinical Practice; Imaging around Hardware and Metal; Recent Advances in T1- and T2-Weighted Imaging of the Abdomen and Pelvis; Recent Advances in Neuro and Spine Imaging; Advances in MR Hardware and Software, and more!

Cardiac MR is explored in this important issue in MRI Clinics of North America. Articles will include: MR physics in practice; Ventricular mechanics: Techniques and applications; MR safety issues particular to women; Novel MR applications for evaluation of pericardial diseases; 4D flow applications for aortic diseases; T1 mapping: technique and applications; ARVD: An updated imaging approach; Imaging the metabolic syndrome; Coronary MRA: how to optimize image quality; Prognostic role of MRI in nonischemic myocardial disease; MRI for valvular imaging; MRI for adult congenital heart disease assessment; Cardiac MRI applications for cancer patients; Applications of PET-MRI for cardiovascular disease; Rings and slings, and more.

Genetic Patterns in Neuroimaging is explored in this important Neuroimaging Clinics issue. Articles include: Brain imaging and genetic risk of congenital malformations; Understanding genetics in neuroimaging; Influence of genetics in neuropathology; Building a bridge between genomics and neuroradiology; Systems genetics approaches to neuroimaging phenotypes; Imaging genetic predictions at an individual level; Brain imaging and genetic risk in the pediatric population; Imaging phenotypes in cognitive diseases; Molecular imaging in genetics; Imaging phenotypes in psychiatric disease; Genomics of brain tumor imaging; Neuroimaging and genetic influence in post-treatment brain neoplasms; Imaging phenotypes in multiple sclerosis; Genetic markers and influences in cerebrovascular malformations, and more.

This issue of Surgical Oncology Clinics of North America, devoted to Imaging in Oncology, is edited by Dr. Vijay Khatri. Articles in this issue include: Imaging of Central Nervous Tumors; Role of Imaging in Head and Neck Malignancies; Imaging of Thoracic Cavity Tumor; Diagnostic Imaging of Hepatobiliary Malignancies; Recent Advances in Genito-Urinary Tract Tumors; Current Status of Imaging for Adrenal Glands; Radiology of Soft Tissue Tumors; Image-Guided Interventions in Oncology; Imaging of Pancreatic Neoplasms; Imaging of Primary Malignant Tumors of Peritoneal and Retroperitoneal Origin; Breast Tumor Imaging; and Application of Intraoperative Imaging in Oncology.

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.
Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Medical imaging now plays a major role in diagnosis, choice of therapy, and follow-up. However, patients are often intimidated by the multiple imaging modalities available, the indications for their use, the imposing equipment, what the examinations are like and how long they last, and the advantages and disadvantages of various procedures. This book is designed to provide explanations for these and other issues in order to relieve some of the anxiety related to medical imaging studies.

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

This third volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work we started with the first and second volumes in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on upper-level courses and NMR spectroscopy across the curriculum. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.

This indispensable guide gives concise yet comprehensive descriptions of the pulse sequences commonly used on modern MRI scanners. The book consists of a total of 65 self-contained sections, each focused on a single subject. Written primarily for scientists, engineers, radiologists, and graduate students who are interested in an in-depth understanding of various MRI pulse sequences, it serves readers with a diverse set of backgrounds by providing both non-mathematical and mathematical descriptions.
The book is divided into five parts. Part I of the book describes two mathematical tools, Fourier transforms and the rotating reference frame, that are useful for understanding MRI pulse sequences. The second part is devoted to a wide variety of radiofrequency (RF) pulses, and the third part focuses on gradient waveforms. Data acquisition, image reconstruction, and physiological monitoring related to pulse sequence design form the subject of Part IV of the book. Once this foundation is established, Part V of the book describes the underlying principles, implementation, and selected applications of many pulse sequences commonly in use today.
The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.
-Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI
-Provides self-contained sections for individual techniques
-Can be used as a quick reference guide or as a resource for deeper study
-Includes both non-mathematical andmathematical descriptions
-Contains numerous figures, tables, references, and worked example problems

This book covers emerging trends in signal processing research and biomedical engineering, exploring the ways in which signal processing plays a vital role in applications ranging from medical electronics to data mining of electronic medical records. Topics covered include statistical modeling of electroencephalograph data for predicting or detecting seizure, stroke, or Parkinson's; machine learning methods and their application to biomedical problems, which is often poorly understood, even within the scientific community; signal analysis; medical imaging; and machine learning, data mining, and classification. The book features tutorials and examples of successful applications that will appeal to a wide range of professionals and researchers interested in applications of signal processing, medicine, and biology.

Titles in the Pocket Tutor series give practical guidance on subjects that medical students and foundation doctors need help with on the go, at a highly affordable price that puts them within reach of those rotating through modular courses or working on attachment. Topics reflect information needs stemming from today's integrated undergraduate & foundation courses: * Common investigations (ECG, imaging, etc) * Clinical skills (surface anatomy, patient examination, etc.) * Clinical specialties that students perceive as too small to merit a textbook (psychiatry, renal medicine) Key Points * Highly affordable price and convenient pocket size format - fits in back pocket * Logical, sequential content: the first principles of emergency imaging, then a guide to understanding a normal image and the building blocks of an abnormal image, before describing specific clinical disorders * Clinical disorders are illustrated by high quality radiographs, ultrasounds, CTs and MRIs, with brief accompanying text that clearly identifies the defining feature of the image * Focuses on the conditions that medical students and foundation doctors are most likely to see and be tested on

FRCS General Surgery: 500 SBAs and EMIs offers the most comprehensive coverage of practice questions for trainees preparing for the FRCS General Surgery exam. Presented in a clear layout, chapters are mapped to the syllabus to deliver structured revision in all the key topics. Featuring a wealth of practice questions and fully descriptive answers, this book provides the essential revision tool to maximise chances of exam success. 500 Single Best Answers and Extended Matching Items, reflecting topics encountered in the exam Answers feature concise, case-based descriptions to consolidate knowledge Highly illustrated to improve understanding of key concepts Extensive evidence-based references to relate theory to clinical practice

First FRCR Anatomy: Practice Cases offers the most up-to-date and comprehensive coverage of practice cases for trainees preparing for the First FRCR Anatomy exam. Chapters are mapped to the syllabus to deliver structured revision in all the key topics, allowing trainees to focus on areas of weakness. Featuring a wealth of practice cases, this book provides the essential revision tool to maximise chances Key Points 240 high quality images, reflecting the breadth of topics encountered in the actual exam Includes practical advice on how to approach revision and useful tips to improve exam technique Visually-enhanced answers improve understanding of key concepts Covers all imaging modalities, including plain x-rays, CT, MRI and ultrasound Complements First FRCR Anatomy: Mock Papers - the complete Anatomy revision package

Presented in a concise and readable format, Pediatric Radiology provides a comprehensive review of 120 pathologies commonly encountered by practicing radiologists and residents. As part of the Rotations in Radiology series, this volume offers a guided approach to imaging diagnosis with a constant depth of coverage, a structured template, and incorporation of applied physics, distinguishing it from other texts in the field. A definition is given for each pathology in this volume, followed by: demographics, clinical presentation, imaging modalities and features, imaging algorithm, applied physics, differential diagnoses and pitfalls, and a bulleted summary of key points. Designed for point-of-care use while training on a specific rotation, as well as for exam review and ongoing reference, Pediatric Radiology is the perfect tool to impart to residents, as well as to refresh for practitioners, the essential facts of common pathologies and the various modalities used to interpret them.

To succeed in radiology, you not only need to be able to interpret diagnostic images accurately and efficiently; you also need to make wise decisions about managing your practice at every level. Whether you work in a private, group, hospital, and/or university setting, this practical resource delivers the real-world advice you need to effectively navigate day-to-day financial decisions, equipment and computer systems choices, and interactions with your partners and staff. Equips you to make the best possible decisions on assessing your equipment needs * dealing with manufacturers * purchasing versus leasing * and anticipating maintenance costs and depreciation. Helps you to identify your most appropriate options for picture archiving systems and radiology information systems * security issues * high-speed lines * storage issues * workstation assessments * and paperless filmless flow. Offers advice on dealing with departments/clinicians who wish to perform radiological procedures and provides strategies for win-win compromises, drawing the line, inpatient-versus-outpatient considerations, cost and revenue sharing, and more.

Medical Image Analysis presents practical knowledge on medical image computing and analysis as written by top educators and experts. This text is a modern, practical, self-contained reference that conveys a mix of fundamental methodological concepts within different medical domains. Sections cover core representations and properties of digital images and image enhancement techniques, advanced image computing methods (including segmentation, registration, motion and shape analysis), machine learning, how medical image computing (MIC) is used in clinical and medical research, and how to identify alternative strategies and employ software tools to solve typical problems in MIC.

Imaging Neuroinflammation provides an overview of the molecular and cellular basis of inflammation and its effects on neuroanatomy, reviews state-of-the-art imaging tools available to measure neuroinflammation, and describes the application of those tools to both preclinical animal disease models and human disease.This book is an authoritative reference on imaging neuroinflammation, MRI, neuroinflammation, MR Spectroscopy of inflammation, Iron imaging in inflammation, and more.

This is an interdisciplinary book that presents the applications of novel laser spectroscopy and imaging techniques for the detection of cancers recently developed by some of the world's most renown researchers. The book consists of three parts and a total of 16 chapters. Each chapter is written by leading experts who are actively seeking to develop novel spectroscopic and analytical methods for cancer detection and diagnosis.In Part I, the authors present fundamentals on optics, atoms and molecules, biophysics, cancer and machine learning. These chapters are intended for those who are not experts in the field but wish to learn about fundamentals' aspects of some of the key topics that are addressed in this book. Particular attention has been given to providing key references for those who wish to go further into the fundamental aspects of atoms and molecules, light-matter interaction, optical instrumentation, machine learning and cancer.In Part II, the authors present key applications of various laser spectroscopic methods in cancer diagnosis. They have provided recent progress in cancer diagnostics obtained by combining laser spectroscopy and machine learning for the analysis of the spectra acquired from biomedical tissues and biofluids.In Part III, the authors present chapters that discuss key developments in the applications of various laser imaging techniques for cancer detection.This is one of the few books that addresses cancer detection and diagnosis using laser spectroscopic and imaging tools with an eye on providing the reader the scientific tools, including machine learning ones.