The field of medical imaging advances so rapidly that all of those working in it, scientists, engineers, physicians, educators and others, need to frequently update their knowledge in order to stay abreast of developments. While journals and periodicals play a crucial role in this, more extensive, integrative publications that connect fundamental principles and new advances in algorithms and techniques to practical applications are essential. Medical Image Processing: Techniques and Applications meets this challenge and provides an enduring bridge in the ever expanding field of medical imaging. It serves as an authoritative resource and self-study guide explaining sophisticated techniques of quantitative image analysis, with a focus on medical applications. The book emphasizes the conceptual framework of image analysis and the effective use of image processing tools. It presents a detailed approach to each application while emphasizing insight and "tricks of the trade," and the applicability of techniques to other research areas. Although each chapter is written by an expert (or experts) in that area and is essentially self-contained, fundamental connections between the different topics are emphasized so that the book forms an integrated whole. The book is designed for end users who wish to update their skills and understanding with the latest techniques in image analysis. Providing unprecedented breadth and detail, it will be a valuable cross-disciplinary resource both at the graduate and specialist level. It is also well suited to supplement and motivate learning in graduate-level image processing classes within biomedical engineering, radiology and computer science.

This scholarly set of well-harmonized volumes provides indispensable and complete coverage of the exciting and evolving subject of medical imaging systems. Leading experts on the international scene tackle the latest cutting-edge techniques and technologies in an in-depth but eminently clear and readable approach. Complementing and intersecting one another, each volume offers a comprehensive treatment of substantive importance to the subject areas. The chapters, in turn, address topics in a self-contained manner with authoritative introductions, useful summaries, and detailed reference lists. Extensively well-illustrated with figures throughout, the five volumes as a whole achieve a unique depth and breath of coverage. As a cohesive whole or independent of one another, the volumes may be acquired as a set or individually.

PNL is the gold standard for the management of large and/or otherwise complex renal stones. Since its introduction in the seventies PNL has undergone considerable evolution, mainly driven by the improvement in access techniques, endoscopic instrument technology, lithotripsy devices and drainage management. The conventional prone position for PNL has been challenged in the last two decades by a variety of modifications, including the supine and Galdakao-modified supine Valdivia positions, which make simultaneous retrograde working access to the collecting system possible and have proven anesthesiological advantages. The Galdakao-modified supine Valdivia position allowed the development of ECIRS (Endoscopic Combined IntraRenal Surgery), a technique exploiting a combined antegrade and retrograde approach to the upper urinary tract, using both rigid and flexible endoscopes with the related accessories. The synergistic teamwork of ECIRS provides a safe and efficient, minimally-invasive procedure for the treatment of all kinds of urolithiasis. The aim of this book is to share with the urologic community worldwide our experience, our standardization of all the steps, and tips and tricks for the procedure.

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine. Radiotherapy is an important part of modern multimodal cancer treatment, and the past several years have witnessed not only substantial improvements in radiation techniques and the use of new beam qualities, but also major strides in our understanding of molecular tumor biology and tumor radiation response. Against this backdrop, the book highlights recent efforts to identify reasonable and clinically applicable biomarkers using broad-spectrum tissue microarrays and high-throughput systems biology approaches like genomics and epigenomics. In particular, it describes in detail how such molecular information is now being exploited for diagnostic imaging and imaging throughout treatment using the example of positron emission tomography. By discussing all these issues in the context of modern radiation oncology, the book provides a broad, up-to-date overview of the molecular aspects of radiation oncology that will hopefully foster its further optimization.

This book shows how the various paradigms of computational intelligence, employed either singly or in combination, can produce an effective structure for obtaining often vital information from ECG signals. The text is self-contained, addressing concepts, methodology, algorithms, and case studies and applications, providing the reader with the necessary background augmented with step-by-step explanation of the more advanced concepts. It is structured in three parts: Part I covers the fundamental ideas of computational intelligence together with the relevant principles of data acquisition, morphology and use in diagnosis; Part II deals with techniques and models of computational intelligence that are suitable for signal processing; and, Part III details ECG system-diagnostic interpretation and knowledge acquisition architectures. Illustrative material includes: brief numerical experiments; and, detailed schemes, exercises and more advanced problems.

This new edition is a complete guide to imaging techniques for the diagnosis of musculoskeletal and breast diseases and disorders. Divided into 29 sections, the book begins with imaging for different musculoskeletal conditions including bone tumours, osteoporosis, and rheumatological disorders. Several chapters are dedicated to subspecialty MRI (Magnetic Resonance Imaging) of the shoulder, wrist, hip and pelvis, knee, and ankle. The remaining sections discuss breast imaging, with a complete chapter dedicated to the male breast. The fourth edition has been fully revised to provide radiologists and trainees with the latest advances and guidelines in the field. The comprehensive text, spanning 700 pages, is further enhanced by radiological images and figures. Key points Complete guide to diagnostic imaging of the musculoskeletal system and breast Fully revised, new edition featuring latest advances and guidelines Highly illustrated with radiological images and figures Previous edition (9789350258835) published in 2012

Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.
*Provides a crucial update of recent advances in imaging techniques
*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research
*Editors are well-respected in this field

Neuroscience is an evolving, complex, and multidisciplinary field of medicine. Neuroradiologists and neuropathologists are an important part of the multidisciplinary team, in addition to neurosurgeons, neurologists, and other disciplines. Featuring over nine hundred images, this practical textbook and atlas combines the specialties of neuroradiology and neuropathology, providing an extensive understanding of the disease process. It offers a comprehensive review of the nervous system diseases, including eye, skeletal muscle, and bone and soft tissue diseases. Topics are covered in chapters arranged by region, allowing for quick reference of conditions such as brain tumors, spinal cord diseases, or congenital malformations. Introductory chapters on pathologic and radiologic techniques are also featured, enabling specialists of both areas to familiarize themselves with the other's subject. Packaged with a password to give the user online access to all the text and images, this is a must-have resource for comprehensive and accurate diagnosis.

This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.This book builds a means of knowledge transfer between the beginners and the experts in NMR as applied to all aspects of life sciences.

Molecular imaging plays an important role in drug discovery and advanced medical practice. A symposium of world leaders in drug research and development, molecular imaging, and medical therapy including regenerative treatment and radiation therapy has led to the publication of this book. Based on the proceedings of the symposium, many excellent ideas and valuable discussions are introduced that will guide the reader toward new advances in photon detection and protein modification as well as new developments in molecular imaging itself. Both protein modification and photon detection are emerging technologies that hold forth the promise of innovative strategies for drug discovery and medical care. The publication of these proceedings is a timely means of sharing significant experience and knowledge with many specialists all over the world. This book will be of great value to a wide variety of researchers in the fields of drug development and molecular imaging technologies, leading to integrated medical therapy and progress in human health.

This volume contains information on the diagnosis, therapy, and prognosis of spinal tumors. Various aspects of different major types of spinal tumors (astrocytomas, ependymomas, and oligodendroglioma) are discussed. Insights into the understanding of molecular pathways involved in tumor biology are explained. Classification of intradural spinal tumors, including the percentages of each of the three major types, is detailed. Symptoms, radiological features, and clinicopathological parameters of spinal cord tumors are explained. Diagnosis, outcome, and prognosis of primary spinal cord and oligodendroglioma are discussed. Diagnosis of some other spinal tumors (e.g., pilomyxoid and chordomas) is also explained. The useful role of neuroimaging in diagnosing spinal teratoid/rhabdoid and gangliogliomas is included. A wide variety of treatments of a number of spinal cord tumor types are presented in detail. Therapies discussed include chemotherapy, surgery, radiosurgery, stereotactic radiosurgery, Cyberknife stereotactic radiotherapy, standard radiation alone, and rhenium-186 intracavity radiation. Also are duiscussed embolozation and spondylectomy. The usefulness of transplantation of human embryonic stem cells-derived oligodendrocyte progenitors and motoneuron progenitors in the repair of injured spinal cord is emphasized. Symptoms of the advent of spinal tumors are pointed out. Introduction to new technologies and their applications to spinal cord tumor diagnosis, treatment, and therapy assessment are explained.

Intended for practising rheumatologists, this book will also be useful for postgraduate students and internists with an interest in rheumatology. It familiarises clinicians involved in the care of patients with spondyloarthritis (SpA) with various common and uncommon imaging features of these disorders. In addition, it will serve as a reference for comparison of imaging features observed by clinicians in their day-to-day practice. The purpose is to make it easier for a rheumatologist to understand the report given by a radiologist in this context and to participate with a basic understanding during multidisciplinary meetings involving radiology colleagues. The aim is to ensure better patient care through shared understanding of imaging findings. Detailed illustrations and explanation of various imaging findings in patients with spondyloarthritis. Basic science of MRI and its sequences have been explained in a simple language which rheumatologists and internists can understand. Various uncommon imaging features like entheseal inflammation and ligamentous ossification have been nicely illustrated. Provides a vivid collection of plain radiographs, MRIs and CT scans obtained during care of patients with spondyloarthritis. Both the axial and peripheral joints have been included.

The main purpose of this book is to present emerging neuroimaging data in order to define the role of primary and secondary structural and hemodynamic disturbances in different phases of traumatic brain injury (TBI) and to analyze the potential of diffusion tensor MRI, tractography and CT perfusion imaging in evaluating the dynamics of TBI. The authors present a new MRI classification of brain stem and hemispheric cortical/subcortical damage localization that is of significant prognostic value. New data are provided regarding the pathogenesis and dynamics of diffuse and focal brain injuries and qualitative and quantitative changes in the brain white matter tracts. It is shown that diffuse axonal injury can be considered a clinical model of multidimensional "split brain" with commissural, association and projection fiber disorders. The book will be of interest for neuroradiologists, neurosurgeons, neurologists and others with an interest in the subject.

This detailed volume will focus on the phenomenon of RNA interference by providing comprehensive coverage of various techniques for in vivo micro/siRNA imaging including the design and synthesis of specific imaging agents and tools, the development of imaging methodologies, and their interpretation. An essential element in the development and optimization of these therapies is the ability to measure the bioavailability and functionality of the RNA/oligonucleotide molecule after administration into the body. Noninvasive imaging provides the necessary set of tools to accomplish this in authentic physiologic environments and across time. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Imaging: Methods and Protocols serves physicians, scientists, and graduate students who are either new to the field of RNA-based imaging and its associated therapeutic applications or who wish to be apprised of recent advances in the state of the art.

This book provides useful information on conventional radiology which will help the pediatricians in their day-to-day office practice as a ready to refer guide in pediatric radiological investigations. Discusses the discovery and evolution of X-rays. Provides an outline of radiation hazards, types of X-rays and radiographic positions in pediatrics. Advent of Digital Radiography and case scenarios of clinical importance added in all essential chapters. Contains information on emergency radiological investigation. This book will be of immense help for UG and PG students, practicing pediatricians and teaching faculties alike.

The developing of in vivo neuroscience techniques is rapidly improving the specificity and sensitivity of measurements of brain function. However, despite improvements in individual methods, it is becoming increasingly clear that the most effective research approaches will be multi-modal. Thus, it is the researchers who are familiar with many in vivo techniques who will be able to make the most substantial contributions to our understanding of dynamic brain function. In Dynamic Brain Imaging: Multi-Modal Methods and In Vivo Applications, leading experts specializing in magnetic resonance, electrophysiology, and optical imaging methods explain basic principles of their respective techniques and demonstrate their power in depicting functional activation patterns en route to a basic understanding of the dynamic processes underlying various neuroimaging signals. The novel results, from various species, provide a new understanding of dynamics of neural activity that span a wide spatiotemporal range. Numerous cutting-edge applications are used as examples to illustrate enticing possibilities of combining techniques toward studies of normal function and disease. Exclusive examples of dynamic functional imaging of the cerebral cortex, olfactory bulb, and retina are used to demonstrate the effectiveness of each method for applications to the neurosciences. State-of-the-art techniques described include multi-photon optical imaging, multi-array electrical recordings, heteronuclear magnetic resonance spectroscopy and functional magnetic resonance imaging. Up-to-date and user-friendly, Dynamic Brain Imaging: Multi-Modal Methods and In Vivo Applications is designed to be accessible to both specialist neurophysiologists and general neuroscientists. It reviews the fundamental, theoretical, and practical principles of magnetic resonance, electrophysiology, and optical methods as applied in the neurosciences and shows how these tools can be used

This book presents a comprehensive overview of current state-of-the-art clinical physiological imaging of brain tumors. It focuses on the clinical applications of various modalities as they relate to brain tumor imaging, including techniques such as blood oxygen level dependent functional magnetic resonance imaging, diffusion tensor imaging, magnetic source imaging/magnetoencephalography, magnetic resonance perfusion imaging, magnetic resonance spectroscopic imaging, amide proton transfer imaging, high angular resolution diffusion imaging, and molecular imaging. Featuring contributions from renowned experts in functional imaging, this book examines the diagnosis and characterization of brain tumors, details the application of functional imaging to treatment planning and monitoring of therapeutic intervention, and explores future directions in physiologic brain tumor imaging. Intended for neuro-oncologists, neurosurgeons, neuroradiologists, residents, and medical students, Functional Imaging of Brain Tumors is a unique resource that serves to advance patient care and research in this rapidly developing field.

The new edition of the book Normal and Abnormal Swallowing, Second Edition, presents an updated practical approach to the role of imaging in the diagnosis and treatment of the patient with dysphagia. Centered around the "gold standard" imaging modality, i.e. videofluorography, the text also includes chapters on other modalities such as ultrasound, computed tomography and magnetic resonance imaging. The broad scope of the text makes it the definitive reference work for professionals already involved with patients with dysphagia as well as newcomers interested in learning more about the imaging approaches to these patients. This is a "must read" for professionals in specialities such as radiology, gastroenterology, otolaryngology, rehabilitation medicine and speech language pathology.

Biomedical image analysis has become a major aspect of engineering sciences, and radiology in particular has become a dominant player in the field. Recent developments have made it possible to use biomedical imaging to view the human body from an anatomical or physiological perspective in a non-invasive fashion. Computer-aided diagnosis consists of developing algorithms and intelligent software components that can automatically process images and spot potential irregularities in the health chain.

The aim of this book is to explain the process of biomedical imaging, from image acquisition to automated diagnosis. This process consists of three thematic areas. The first is dedicated to the acquisition process and the underlying properties of images from a physics-oriented perspective. The second part addresses the dominant state-of-the-art methodologies behind content extraction and interpretation of medical images. The third section presents an application-based example, which develops solutions to address the particular needs of various diagnoses.

This complete volume is an exceptional tool for radiologists, research scientists, senior undergraduate and graduate students in health sciences and engineering, and university professors. This book offers a unique guide to the entire chain of biomedical imaging, explaining how image formation is done, and how the most appropriate algorithms are used to address demands and diagnoses.

In Vivo EPR (ESR) is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging.
Key Features:

-History of In Vivo EPR,
-Principles of Imaging-Theory and Instrumentation,
-Time-domain Radio Frequency EPR Imaging,
-The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques,
-Potential Medical (Clinical) Applications of EPR,
-Combining NMR and EPR/ESR for In Vivo Experiments.

A comprehensive and contemporary reference work covering the basic science and clinical applications of positron emission tomography. This book reflects the tremendous increase in interest in PET as both a clinical and research imaging modality in the past 10 years. Written by experts in the field and edited by those involved in PET development, and training of scientists and medical specialists. Positron Emission Tomography - basic science and clinical practice thoroughly explains the principles, clinical applications and economic aspects of PET today. Chapters go into detail on PET applications in oncology, the central nervous system, cardio-respiratory systems, infectious diseases and pediatrics. Discussions are also found on technology design and evaluation, PET in drug discovery and development in imaging gene expression and therapy. Peter E. Valk MB BS FRACP is based in the Northern California PET Imaging Center, Sacramento, CA USA, Dale L. Bailey PhD FIPEM ARCP is based in the Department of Nuclear Medicine, Guy's Hospital, London UK, David W. Townsend PhD is based in the Department of Radiology, University of Pittsburgh, Pittsburgh, PA USA, Michael N. Maisey MD FRCP FRCR is Professor at the Department of Radiological Sciences, Guy's Hospital, London UK.