This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.

This book presents novel and advanced topics in Medical Image Processing and Computational Vision in order to solidify knowledge in the related fields and define their key stakeholders. It contains extended versions of selected papers presented in VipIMAGE 2013 - IV International ECCOMAS Thematic Conference on Computational Vision and Medical Image, which took place in Funchal, Madeira, Portugal, 14-16 October 2013. The twenty-two chapters were written by invited experts of international recognition and address important issues in medical image processing and computational vision, including: 3D vision, 3D visualization, colour quantisation, continuum mechanics, data fusion, data mining, face recognition, GPU parallelisation, image acquisition and reconstruction, image and video analysis, image clustering, image registration, image restoring, image segmentation, machine learning, modelling and simulation, object detection, object recognition, object tracking, optical flow, pattern recognition, pose estimation, and texture analysis. Different applications are addressed and described throughout the book, comprising: biomechanical studies, bio-structure modelling and simulation, bone characterization, cell tracking, computer-aided diagnosis, dental imaging, face recognition, hand gestures detection and recognition, human motion analysis, human-computer interaction, image and video understanding, image processing, image segmentation, object and scene reconstruction, object recognition and tracking, remote robot control, and surgery planning. This volume is of use to researchers, students, practitioners and manufacturers from several multidisciplinary fields, such as artificial intelligence, bioengineering, biology, biomechanics, computational mechanics, computational vision, computer graphics, computer science, computer vision, human motion, imagiology, machine learning, machine vision, mathematics, medical image, medicine, pattern recognition, and physics.

Although many radiation protection scientists and engineers use dose coefficients, few know the origin of those dose coefficients. This is the first book in over 40 years to address the topic of radiation protection dosimetry in intimate detail. Advanced Radiation Protection Dosimetry covers all methods used in radiation protection dosimetry, including advanced external and internal radiation dosimetry concepts and regulatory applications. This book is an ideal reference for both scientists and practitioners in radiation protection and students in graduate health physics and medical physics courses. Features: A much-needed book filling a gap in the market in a rapidly expanding area Contains the history, evolution, and the most up-to-date computational dosimetry models Authored and edited by internationally recognized authorities and subject area specialists Interrogates both the origins and methodologies of dose coefficient calculation Incorporates the latest international guidance for radiation dosimetry and protection

Can drug development and evaluation be improved by the use of positron emission tomography (PET)? PET is now well established and many PET centres participate in networks that warrant the quality of their research. PET allows one to follow the effect of a drug on a variety of patients' metabolic parameters. In addition, PET may be used to follow the fate in vivo of a compound, allowing visualisation of its binding to specific receptors and a direct study of the mechanism of drug action in normal and pathological situations. The book shows the fields in which PET offers new and unique information for the development of drugs (conception, toxicity, pharmacokinetics and metabolism, clinical research, and relations between clinical and biological effects) and evaluates fields in which PET may shorten the development time of drugs. Audience: Professionals in the pharmaceutical industry in all areas of drug discovery and pharmacology, pre-clinical testing, pharmacokinetics and metabolism, clinical evaluation, registration and regulatory affairs. Government health authority representatives who assess data and documentation on new drug development and radiopharmaceuticals. Academic experts concerned with any of these areas.

In the past few years it has become clear that left ventricular dysfunction, even of severe degree, may be reversible after coronary revascularization in some patients. As a result, myocardial viability has captured the imagination of researchers and clinicians seeking to unravel the cellular and subcellular mechanisms and define appropriate diagnostic modalities. These diagnostic modalities include: cardiac catheterization, positron-emission tomography, magnetic resonance imaging, two-dimensional echocardiography and single-photon imaging. This book brings together a diverse array of information in a comprehensive and concise fashion using a template of 10 chapters written by experts in the field. It should be of value to cardiologists, radiologists, nuclear medicine specialists, cardiac surgeons, anesthesiologists, internists and basic researchers and their trainees who are involved in the management of patients with coronary artery disease in whom myocardial viability is a clinically relevant issue.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Interventional Radiology, third edition, is an invaluable resource for interventional radiologists, general radiologists, vascular surgeons, and trainees-anyone who requires an easily accessible, highly visual reference in this complex area of imaging. Dr. Brandt C. Wible and his team of highly regarded experts provide up-to-date information on more than 100 interventional radiologic procedures to help you make informed decisions at the point of care. Chapters are well organized, referenced, and lavishly illustrated, creating a useful learning tool for readers at all levels of experience as well as a handy reference for daily practice.. Provides a comprehensive, expert reference for review and preparation of common and infrequently performed procedures, with detailed "step-by-step" instructions for conducting image-guided interventions in various clinical scenarios . Covers vascular venous, arterial, and lymphatic procedures, with specific attention to thromboembolic, posttransplant, and oncologic therapies . Addresses emerging nonvascular image-guided treatments in pain management, neurologic and musculoskeletal procedures, and others . Contains new procedures chapters on endovascular treatments for pulmonary embolisms and deep vein thrombosis, prostate artery embolization, pelvic venous disorders, and percutaneous/endovascular arteriovenous fistula (AVF) creation . Features sweeping updates throughout, including updated guidelines and recommendations from the Society of Interventional Radiology . Offers more than 3,200 images (in print and online), including radiologic images, full-color medical illustrations, instructional photo essays, and clinical and histologic photographs . Clearly demonstrates procedural steps, complications, treatment alternatives, variant anatomy, and more?all fully annotated to highlight the most important diagnostic information . Organized by procedure type, allowing for quick comparison of different procedural techniques that may have complementary or alternative roles in managing specific disease states . Builds on the award-winning second edition, which won first prize in the British Medical Association's Medical Book Awards, Radiology category . Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Biomedical signals provide unprecedented insight into abnormal or anomalous neurological conditions. The computer-aided diagnosis (CAD) system plays a key role in detecting neurological abnormalities and improving diagnosis and treatment consistency in medicine. This book covers different aspects of biomedical signals-based systems used in the automatic detection/identification of neurological disorders. Several biomedical signals are introduced and analyzed, including electroencephalogram (EEG), electrocardiogram (ECG), heart rate (HR), magnetoencephalogram (MEG), and electromyogram (EMG). It explains the role of the CAD system in processing biomedical signals and the application to neurological disorder diagnosis. The book provides the basics of biomedical signal processing, optimization methods, and machine learning/deep learning techniques used in designing CAD systems for neurological disorders.

Imaging modalities in radiology produce ever-increasing amounts of data which need to be displayed, optimized, analyzed and archived: a "big data" as well as an "image processing" problem. Computer programming skills are rarely emphasized during the education and training of medical physicists, meaning that many individuals enter the workplace without the ability to efficiently solve many real-world clinical problems. This book provides a foundation for the teaching and learning of programming for medical physicists and other professions in the field of Radiology and offers valuable content for novices and more experienced readers alike. It focuses on providing readers with practical skills on how to implement MATLAB (R) as an everyday tool, rather than on solving academic and abstract physics problems. Further, it recognizes that MATLAB is only one tool in a medical physicist's toolkit and shows how it can be used as the "glue" to integrate other software and processes together. Yet, with great power comes great responsibility. The pitfalls to deploying your own software in a clinical environment are also clearly explained. This book is an ideal companion for all medical physicists and medical professionals looking to learn how to utilize MATLAB in their work. Features Encompasses a wide range of medical physics applications in diagnostic and interventional radiology Advances the skill of the reader by taking them through real-world practical examples and solutions with access to an online resource of example code The diverse examples of varying difficulty make the book suitable for readers from a variety of backgrounds and with different levels of programming experience.

This book summarizes 20 years of work on the kinetics of blood-brain transfer and metabolism mechanisms in mammalian brain. The substances affiliated with these mechanisms include glucose, amino acids, monocarboxylic acids, and oxygen. These substances are important to energy metabolism and neurotransmission in the mammalian brain at rest and during activation.

To understand the processes addressed by these mechanisms, the book examines the kinetics of compartmentation and compartmental analysis, particularly as they relate to transporter, enzyme, and receptor function. Compartments are subsets of substances separated by transporters and receptors in membranes, and enzymes in cells.

This book is divided in six major chapters covering compartmental analysis, kinetic analysis of transport and metabolism, blood-brain transfer and metabolism of glucose, amino acids, and oxygen, and amino acid metabolism and interaction of amino acid metabolites with receptors.

Bioimaging is a sophisticated non-invasive and non-destructive technique for direct visualization of biological processes. Highly luminescent quantum dots combined with magnetic nanoparticles or ions form an exciting class of new materials for bioimaging. These materials can be prepared in cost-effective ways and show unique optical behaviours. Magnetic Quantum Dots for Bioimaging explores leading research in the fabrication, characterization, properties, and application of magnetic quantum dots in bioimaging. * Covers synthesis, properties, and bioimaging techniques. * Discusses modern manufacturing technologies and purification of magnetic quantum dots. * Explores thoroughly the properties and extent of magnetization to various imaging techniques. * Describes the biocompatibility, suitability, and toxic effects of magnetic quantum dots. * Reviews recent innovations, applications, opportunities, and future directions in magnetic quantum dots and their surface decorated nanomaterials. This comprehensive reference offers a roadmap of the use of these innovative materials for researchers, academics, technologists, and advanced students working in materials engineering and sensor technology.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires . Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centers in India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This book is based on deep learning approaches used for the diagnosis of neurological disorders, including basics of deep learning algorithms using diagrams, data tables, and practical examples, for diagnosis of neurodegenerative and neurodevelopmental disorders. It includes application of feed-forward neural networks, deep generative models, convolutional neural networks, graph convolutional networks, and recurrent neural networks in the field of diagnosis of neurological disorders. Along with this, data pre-processing including scaling, correction, trimming, normalization is also included. Offers a detailed description of the deep learning approaches used for the diagnosis of neurological disorders Demonstrates concepts of deep learning algorithms using diagrams, data tables, and examples for the diagnosis of neurodegenerative disorders; neurodevelopmental, and psychiatric disorders. Helps build, train, and deploy different types of deep architectures for diagnosis Explores data pre-processing techniques involved in diagnosis Include real-time case studies and examples This book is aimed at graduate students and researchers in biomedical imaging and machine learning.

This book provides a practically applicable manual to the utilisation of ultrasound in rheumatology. Each chapter includes high-quality diagrams of each anatomical region covered, accompanied by an ideal scan with written and pictorial demonstrations, as well as an ideal ultrasound image, that has been obtained via a high-end machine for optimal image quality. This systematic approach to describing the application of ultrasound in rheumatology enables the reader to develop a deep understanding of how to correctly make use of ultrasound technologies in their daily practice. Ultrasound in Rheumatology: A Practical Guide for Diagnosis is an easy to follow guide to the application of ultrasound in rheumatology and is a valuable resource for the trainee and practising rheumatologist seeking a guide on the correct use of ultrasound.

Thoracic Imaging: Case Review, by Phillip M. Boiselle, MD, Theresa C. McLoud, MD and Gerald F. Abbott, MD, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this title in the popular Case Review series features all-new cases and superb-quality accompanying images that explore the newest imaging modalities, including new treatment guidelines for lung cancer, HIV/AIDS, and pneumonia. This complete study of thoracic imaging has been organized for quick reference and easy board and recertification review. Easily find and study the most challenging topics from among approximately 200 cases-organized by difficulty - and 400 images - with questions and answers, diagnoses, commentary, references, and cross-references to Thoracic Radiology: The Requisites. Presents more than 145 high-yield case studies organized by level of difficulty, helping you build your knowledge and confidence in stages. All cases have been refreshed and rewritten to capture the latest clinical implications and diagnostic pearls on thoracic conditions that you will be tested on. Includes multiple-choice questions, answers, and rationales that mimic the format of certification exams. Uses short, easily digestible chapters covering the full range of thoracic imaging for efficient, effective learning and exam preparation. Features hundreds of high-quality, full-color images (many new to this edition) representing a wide range of clinical situations encountered in thoracic imaging. Images include chest radiographs, CT, PET-CT, and MRI to help you expand your visual identification and diagnostic skills. Clearly see and interpret 400 high-quality, state-of-the-art images representing a wide range of clinical situations encountered in thoracic imaging. Get fresh perspectives from 200 updated or new cases reflecting the most recent changes in thoracic imaging, including PET-CT, emerging pulmonary infections, smoking-related lung diseases, Fleischner guidelines for management of incidentally detected lung nodules, and ground glass and part-solid lung nodules. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty. A top-selling volume of the popular Case Review series with new and improved images throughout is the perfect tool to prepare for the toughest cases in Thoracic radiology.

The textbook begins with exercises related to radioactive sources and decay schemes. The problems covered include series decay and how to determine the frequency and energy of emitted particles in disintegrations. The next chapter deals with the interaction of ionizing radiation, including the treatment of photons and charged particles. The main focus is on applications based on the knowledge of interaction, to be used in subsequent work and courses. The textbook then examines detectors and measurements, including both counting statistics and properties of pulse detectors. The chapter that follows is dedicated to dosimetry, which is a major subject in medical radiation physics. It covers theoretical applications, such as different equilibrium situations and cavity theories, as well as experimental dosimetry, including ionization chambers and solid state and liquid dosimeters. A shorter chapter deals with radiobiology, where different cell survival models are considered. The last chapter concerns radiation protection and health physics. Both radioecology and radiation shielding calculations are covered. The textbook includes tables to simplify the solutions of the exercises, but the reader is mainly referred to important websites for importing necessary data.

Since the introduction of myocardial perfusion imaging and radionuclide angiography in the mid-seventies, cardiovascular nuclear medicine has undergone an explosive growth. The use of nuclear cardiology techniques has become one of the cornerstones of the noninvasive assessment of coronary artery disease. In the past 15 years major steps have been made from visual analysis to quantitative analysis, from planar imaging to tomographic imaging, from detection of disease to prognosis, and from separate evaluations of perfusion, metabolism, and function to an integrated assessment of myocardial viability. In recent years many more advances have been made in cardiovascular nuclear imaging, such as the development of new imaging agents, reevaluation of existing procedures, and new clinical applications. This book describes the most recent developments in nuclear cardiology and also addresses new contrast agents in MRI. What's New in Cardiac Imaging will assist the clinical cardiologist, the cardiology fellow, the nuclear medicine physician, and the radiologist in understanding the most recent achievements in clinical cardiovascular nuclear imaging.

Master the radiography skills needed to produce high-quality images every time! With straightforward coverage of imaging principles, Radiographic Imaging and Exposure, 6th Edition describes exposure techniques and how to acquire, process, and display digital images. Not only does this book help you reduce the need for repeat images, it includes problem-solving guidelines for troubleshooting situations. Written by noted educator Terri L. Fauber, this book also provides the essential knowledge needed to pass the ARRT certification exam. Extensive digital radiography coverage explains how to acquire, process, and display digital images, along with important aspects of data management. Straightforward focus on imaging and exposure provides the knowledge you need to become a competent radiographer. Concise, easy-to-understand writing style makes the content easily accessible. Patient Protection Alerts highlight the variables that impact patient exposure and how radiographers can control them. Relationships sections summarize the connections between radiographic concepts, calling attention to how they relate to one another. Mathematical Applications sections show how mathematical concepts and formulas are applied in the clinical setting. Bulleted summaries at the ends of chapters offer a quick review of key concepts. Review questions are provided in every chapter, with answers in the back of the book. Convenient appendixes include Important Relationships, Mathematical Applications, and Patient Protection Alerts, providing a quick reference to important concepts and formulas. Glossary of key terms defines need-to-know terminology covered throughout the book. NEW! Coverage of digital imaging includes two chapters with expanded image processing and new content on data management. NEW! Updated content reflects the newest curriculum standards outlined by the ARRT and ASRT, and provides everything you need to prepare for the boards and for clinical success. NEW! Additional digital images are included in the digital imaging chapters, as well as the Scatter Control and Exposure Technique Selection chapters. NEW! Expanded coverage of digital fluoroscopy includes a thorough explanation of fluoroscopic operational features that impact the patient dose in Dynamic Imaging: Fluoroscopy chapter.

Recent years have seen remarkable advances in the devel- ment of techniques that have direct applications in neurological research. In consequence, the circulatory and metabolic status of the brain can be measured and correlated with changes m structure often noninvasively, m the same - and integrated function, perimental subIect This has stimulated an increased awareness of the complexity, under normal and pathological conditions, of the interdependence of these factors. Through the application of the methods described in this volume, however, these complexities can now be analyzed. The chapters m this volume present methodological - scriptions of some of the most powerful "physicochemical" methods for studymg the brain. Multidisciplmary teams are - quired to develop some of these methods, which are extremely expensive m terms of capital equipment costs and technological personnel support Thus, they will likely remain restricted to malor medical research centers Nevertheless, many recent concepts of brain responses to disease are a result of their application We have been fortunate m convincing active, leading sci- tists to contribute to this volume. The descrrptions of the basic prmciples of each method, and its applications and limitations, are derived primarily from their personal experiences. The first two chapters (Rowan, Auer) deal with methods for assessing brain hemodynamics. The two subsequent chapters (Greenberg; He- covitch) describe autoradiography and positron emission tomog- phy techniques, which provide quantitative measurements of brain metabolism as well as blood flow.

This second edition is completely revised and improved and contains eight new chapters and six new appendixes. In addition to the theoretical background on light propagation through diffusive media, this update also provides new didactical material, including: A comprehensive statistical approach to the photon penetration depth in diffusive media. An introduction to anomalous transport. An anisotropic transport approach within the framework of diffusion theory. An introduction to the invariance properties of radiative transfer in non-absorbing media. A heuristic explanation of ballistic photon propagation. An expanded description of core Monte Carlo simulation methods. A series of new analytical solutions of the diffusion equation for new geometries. Some original solutions in the time domain of the diffusion equation in the presence of Raman and fluorescence interactions. New MATLAB (R) codes of the presented solutions. A revised and enlarged set of numerical Monte Carlo results for verification of the presented solutions. An augmented bibliography covering the field of tissue optics. Although the theoretical and computational tools provided in this book have their primary use in the field of biomedical optics, there are many other applications in which they can be used, including, for example, analysis of agricultural products, study of forest canopies or clouds, and quality control of industrial food, plastic materials, or pharmaceutical products, among many others.

This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing chromatin structure with magnetic tweezers; and fluorescence correlation spectroscopy on genomic DNA in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and through, Nanoscale Imaging: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing and expanding field.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Head and Neck, fourth edition, is an invaluable resource for neuroradiologists, general radiologists, and trainees-anyone who requires an easily accessible, highly visual reference on today's head and neck imaging. Dr. Philip R. Chapman and his team of highly regarded experts provide up-to-date information on recent advances in disease identification, imaging techniques, and tumor staging to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool as well as a handy reference for daily practice. Serves as a one-stop resource for key concepts and information on head and neck imaging, including a wealth of new material and content updates throughout Features more than 2,800 illustrations including radiologic images, full-color illustrations, clinical and gross pathology photographs, and histology photographs, as well as an additional 2,200 digital images online Features numerous new chapters and updates from cover to cover including changes to staging of HPV-related/p16(+) oropharyngeal squamous cell carcinoma; new metastatic disease imaging recommendations, protocols, and treatments; and the latest knowledge on the genetics of various congenital conditions and syndromes Reflects new Lugano and WHO classifications for staging lymphomas; updates in the AJCC Cancer Staging Manual, 8th Edition; and updates from the 2018 ISSVA Classification regarding avoidance of outdated and inappropriate terminology and nomenclature that can lead to misdiagnosis or inappropriate treatments Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

A goldmine of theoretical insights and practical suggestions, Achieving Excellence in Medical Education, Second Edition explores the essential question facing medical educators and learners today: What is our vision of educational excellence, and what can we do to enhance our performance? Among the topics explored within this updated, engaging, informative, and thought-provoking text are: * Education's position as a priority of medical schools * Seminal educational insights from non-medical educators * Best practices of outstanding educators and learners * Promises and pitfalls of new educational technologies * Key resources for promoting excellence in medical education * Medical education's role in preparing future leaders * Leadership roles for medical schools in universities and society Reviews of the first edition: "This is an eloquent, quotable, and inspirational book that provides a template for "Achieving Excellence in Medical Education." - Journal of the American Medical Association "Gunderman is an accomplished educator, well known as a thoughtful and provocative teacher. . . I recommend his book to department chairs, clerkship and residency program directors, and education professionals who are shaping the future of medical education." - New England Journal of Medicine

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics, injury biomechanics, biomechanics of the heart and vascular system, algorithms of computational biomechanics for medical image analysis, and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, Computational Biomechanics for Medicine: Measurments, Models, and Predictions provides an opportunity for specialists in the field to present their latest methodologies and advancements.

This book is based on the best contributions to the advancement of bioimpedance knowledge and use from the Latin American Congress series, CLABIO. Basic bioimpedance facts as well as promising and original contributions to bioimpedance theory and applications are presented, giving the reader stimulating material for reflection, decision making, and further experiments. Contributions come from a diverse international pool of experts and address topics on electrode and skin impedance modelling, tomography, spectroscopy, instrumentation, and clinical applications.