Recent advances in technology have opened up new possibilities in the diagnosis and treatment of cerebrospinal vascular diseases. It is now possible to use magnetic resonance imaging to map brain function and metabolism as an aid to diagnosis. Novel applications of magnetic resonance angiography allow three-dimensional imaging, and the magnetization transfer contrast technique gives us a new window on cerebral vascular function. This volume presents work in all these fields as well as previewing the techniques of endovascular surgery for cerebrospinal vascular diseases. These include modern stereotactic radiosurgery for arteriovenous malformations and for angiographically occult vascular malformations of the brain. This book presents an overview of the latest applications of technology to this rapidly developing and challenging field.

Contrast agents for medical ultrasound imaging is a field of growing interest. A large amount of literature has been published on the medical applications of such contrast agents. However, there is no textbook giving a broad overview of the physics and acoustics of the agents. This monograph aims to fill this gap. The book is written by a physicist, from a physics point of view, and it tries to draw links from the physics and acoustics to the medical imaging methods, but medical applications are mainly included for background information. The book consists of nine chapters. The first three chapters give a broad overview of the acoustic theory for bubble-sound interaction, both linear and nonlinear. Most contrast agents are stabilized in a shell, and this shell can have a strong influence on the interaction between the bubbles and the ultrasound. The effect of the shell is given special attention, as this is not easily found in other bubble literature. The following chapters, 4, 5, 6, and 7, describe experimental and theoretical methods used to characterize the acoustic properties of the agents, and results of studies on some agents. Chapter 8 shows how the theory and the experimental results can be combined and used to model various phenomena by means of computer simulations. The main purpose of the simulations is to get insight into the mechanisms behind the described phenomena, not to get accurate predictions and values. The book is aimed at both newcomers into the field, as well as those who are more experienced but want better insight into the acoustics of the contrast bubbles.

The healthcare industry is predominantly moving towards affordable, accessible, and quality health care. All organizations are striving to build communication compatibility among the wide range of devices that have operated independently. Recent developments in electronic devices have boosted the research in the medical imaging field. It incorporates several medical imaging techniques and achieves an important goal for health improvement all over the world. Despite the significant advances in high-resolution medical instruments, physicians cannot always obtain the full amount of information directly from the equipment outputs, and a large amount of data cannot be easily exploited without a computer. Machine Learning and AI Techniques in Interactive Medical Image Analysis discusses how clinical efficiency can be improved by investigating the different types of intelligent techniques and systems to get more reliable and accurate diagnostic conclusions. This book further introduces segmentation techniques to locate suspicious areas in medical images and increase the segmentation accuracy. Covering topics such as computer-aided detection, intelligent techniques, and machine learning, this premier reference source is a dynamic resource for IT specialists, computer scientists, diagnosticians, imaging specialists, medical professionals, hospital administrators, medical students, medical technicians, librarians, researchers, and academicians.

The sixteen chapters included in this book were written by invited experts of international recognition and address important issues in Medical Image Processing and Computational Vision, including: Object Recognition, Object Detection, Object Tracking, Pose Estimation, Facial Expression Recognition, Image Retrieval, Data Mining, Automatic Video Understanding and Management, Edges Detection, Image Segmentation, Modelling and Simulation, Medical thermography, Database Systems, Synthetic Aperture Radar and Satellite Imagery.

Different applications are addressed and described throughout the book, comprising: Object Recognition and Tracking, Facial Expression Recognition, Image Database, Plant Disease Classification, Video Understanding and Management, Image Processing, Image Segmentation, Bio-structure Modelling and Simulation, Medical Imaging, Image Classification, Medical Diagnosis, Urban Areas Classification, Land Map Generation.

The book brings together the current state-of-the-art in the various multi-disciplinary solutions for Medical Image Processing and Computational Vision, including research, techniques, applications and new trends contributing to the development of the related areas.

MRI has become an important tool in the management of patients with diseases of the gastrointestinal tract, such as rectal cancer and inflammatory bowel diseases. This book, written by distinguished experts in the field, discusses in detail the technical, practical, and clinical aspects of MRI of the gastrointestinal tract. The chapters on technique encompass the most recent developments and address such topics as contrast media, high field strength MRI, and perfusion MRI. Subsequently, individual chapters are devoted to the clinical applications of MRI in the different parts of the gastrointestinal tract. Both established applications and new frontiers are considered, with the aid of numerous high-quality illustrations. By combining chapters dedicated to technical aspects and clinically oriented chapters, this book will prove very instructive for the novice while simultaneously offering experienced practitioners further insights into the value of MRI of the gastrointestinal tract.

Cardiac ultrasound has rapidly developed into one of the most important clinical methods for diagnosis and follow-up of patients with heart disease and has changed the practice of cardiology permanently. In addition to improving image quality, most of the progress relies on digital image acquisition, storage, and quantitative analysis equipment. Automatic endocardial detection and three- dimensional reconstruction are now being developed. The progress with contrast echocardiography for myocardial perfusion imaging and results with tissue characterization is slow, but ever increasing, illustrating that the full potential of the method has not yet been explored. All of these digital techniques are extensively dealt with in this volume. Computerized tools will help the clinical cardiologists in their daily practice and stimulate further development to gen- uinely improve patient care in the coming years. We wish to thank the authors to this volume for their excellent contribution and Mrs. T. van der Kolk for secretarial assistance. IX Contributors F. J. ten Cate Thorax Center, Erasmus University, P. O. Box 1738, 3000 DR Rotterdam, The Netherlands R. Erbel II Medical Clinic, Johannes Gutenberg University, Langenbeckstr. 1, P. O. Box 3960, D-6500 Mainz, FRG Co-authors: R. Zotz, B. Henkel, G. Schreiner, C. Steuernagel, R. Zahn, H. Kopp, W. Clas, R. Brennecke, P. Schweizer, J. Meyer S. B. Feinstein Division of Cardiology, Box 44, University of Chicago, 950 East 59th Street, Chicago, IL 60637, USA D. G. Gibson Department of Cardiology, Brompton Hospital, Fulham Road, London SW3 6HP, UK Co-author: R. B. Logan Sinclair E.

This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a "toolbox" for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: * A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome * A pedagogical approach to the methodology * Engaging the reader and student with a clear, yet critical presentation of the applications

The FRCR examination was recently changed and now comprises two modules: physics and radiological anatomy. The anatomy module is new, and consists of 20 radiological images, with 5 questions on each image, 100 questions in all. The anatomy examination lasts for 75 minutes and incorporates 20 separate images (cases) with 5 questions per case, producing a total of 100 questions. The cases will be presented at computer work-stations, with separate written answer sheets for completion. In this book we present 5 complete `mock' anatomy examinations, with a total of 500 questions. We have stayed true to the lay out of the RCR sample questions and answer sheets to ensure familiarity. The anatomical structures should not be ambiguous and, if necessary, there will be more than one arrow to indicate the appropriate structure (a concept that has been included in some of the example questions in this book). As a rule, the candidate should make an attempt to answer ALL questions in the exam as there is no negative marking. It is advised that answers be as complete as possible, for instance the use of `left' or `right' if this can be derived from the image, or rather than simply stating `acromion', use the `acromion process of the scapula' - if you have the knowledge, use it! This book should not be used as a primary revision tool, rather a practice aid to test the candidate against the clock in exam conditions and highlight any areas of weakness or imaging examinations that the candidate may be unfamiliar with. Primary revision is suggested by using traditional anatomy alongside radiology-based anatomy textbooks. It is also necessary to experience everyday radiological investigations, and even more specialist investigations, as essentially any type of radiological image can be used for assessment of anatomical knowledge in this examination. The authors provide explanatory answers, and have also included extra images to accompany their explanations. In addition there are references to key revision resources, and they have also given advice on exam technique. They have first hand experience of running courses on the new format FRCR anatomy exam, and are therefore the perfect authors for the subject. Key Points 100% relevant to the new format Authors run FRCR Part 1 courses 500 questions

This book constitutes the Proceedings of the 26th Symposium on Acoustical Imaging held inWindsor, Ontario, Canada during September 9-12, 2001. This traditional scientific event is recognized as a premier forum for the presentation of advanced research results in both theoretical and experimental development. The lAIS was conceived at a 1967Acoustical Holography meeting in the USA. Since then, these traditional symposia provide an opportunity for specialists who are working in this area to make new acquaintances, renew old friendships and present recent results of their research. Our Symposium has grown significantly in size due to a broad interest in various topics and to the quality of the presentations. For the firsttime in 40 years, the IAIS was held in the province of Ontario in Windsor, Canada's Automotive Capital and City of Roses. The 26th IAIS attracted over 100specialists from 13countries representing this interdisciplinary field in physical acoustics, image processing, applied mathematics, solid-state physics, biology and medicine, industrial applications and quality control technologies. The 26th lAIS was organized in the traditional way with only one addition-a Special Session "History of Acoustical Imaging" with the involvement of such well known scientists as Andrew Briggs, Noriyoshi Chubachi, Robert Green Jr., Joie Jones, Kenneth Erikson, and Bernhard Tittmann. Many of these speakers are well known scientists in their fields and we would like to thank them for making this session extremely successful.

Unraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques - and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains. This book starts with Brodmann's post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of "in vivo Brodmann mapping" using high-field MRI, which was introduced in the early 21st century.

Dr. William Herring's Learning Radiology: Recognizing the Basics, 5th Edition, remains the leading introductory radiology text for medical students and others who are required to read and interpret common radiologic images. Using an easy-to-follow pattern recognition approach, this clearly written, highly illustrated text teaches how to differentiate normal and abnormal images of all modalities. From the basics of patient safety, dose reduction, and radiation protection to the latest information on ultrasound, MRI, and CT, it provides a complete, up-to-date introduction to radiology needed by today's students. Uses a clear, conversational writing style-with a touch of humor-to explain what you need to know to effectively interpret medical images of all modalities. Teaches how to arrive at a diagnosis by following a pattern recognition approach, and logically overcome difficult diagnostic challenges with the aid of decision trees. Employs an easy-to-read, bullet-point format, including bolded key points and icons designating special content: Diagnostic Pitfalls, Really Important Points, Take-Home Points, and Weblinks. Features more than 850 high-quality illustrations, useful tables, case study questions, and teaching boxes throughout. Shares the extensive knowledge and experience of esteemed author Dr. William Herring, a skilled radiology teacher and the host of his own specialty website, www.learningradiology.com. Offers quick review and instruction for medical students, residents, and fellows, as well as those in related fields such as nurse practitioners and physician assistants. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud-as well as access bonus content, including new appendices covering the Discovery of X-rays, Diagnostic Radiology Signs, and Artificial Intelligence in Radiology; USMLE-style Q 30 videos; and more.

This book focuses on the processing, materials design, characterisation, and properties of polymer composites and nanocomposites for use as electromagnetic radiation shielding materials and to enhance radiation shielding capacity in order to meet the safety requirements for use in medical X-ray imaging facilities. It presents an in-depth analysis of materials synthesis methods such as melt-mixing, ion-implantation, solution casting and electrospinning. In addition, it measures the X-ray attenuation behaviour of fabricated composites and nanocomposites in four major types of X-ray equipment, namely general radiography, mammography, X-ray absorption spectroscopy and X-ray fluorescence spectroscopy units. Given its scope, the book will benefit researchers, engineers, scientists and practitioners in the fields of medical imaging, diagnostic radiology and radiation therapy.

Musculoskeletal Ultrasound is the latest edition of this comprehensive reference guide to the applications of this imaging technique.The book is edited by US- based experts Marnix van Holsbeeck and Joseph Introcaso. The book is divided into 23 chapters, beginning with the physical principles of ultrasound imaging. Subsequent chapters cover the sonography of particular anatomical structures of the musculoskeletal system, from muscle, ligaments and tendons, to peripheral nerves, skin and bone. Later chapters cover the sonography of broader anatomical areas, including shoulder, arm and hand, leg and foot, chest and abdominal wall. This edition of Musculoskeletal Ultrasound reflects the rapid growth of this technique, with more information on ultrasound anatomy, indications for ultrasound examinations, pathology and signs of disease. A new glossary has been included with important terminology. Key Points Latest edition of this comprehensive reference guide to musculoskeletal ultrasound Previous edition published 2001 (9780323000185) Edited by US experts from Wayne State University School of Medicine, Detroit, and Clinical Neuroscience Programs, Ministry Healthcare Eastern Region, Wisconsin

This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of 'contrast' in the context of medical imaging. This introductory text separates the principles by which 'signals' are generated and the subsequent 'reconstruction' processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of 'reconstruction' are shared by some imaging methods despite relying on different physics to generate the 'signals'. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers.

For the last half of the 20th century cobalt-60 units were the mainstay of radiation treatments for cancer. This book describes the development of the first cobalt -60 unit in the United States and the man behind it, Leonard Grimmett. Conceptually conceived before World War II it only became possible because of the development of nuclear reactors during the war. The initial idea was to replace the radium in the contemporary units of the time with cobalt-60, but with the realization that the reactors could produce much more cobalt-60 than originally thought the design of the cobalt-60 unit was drastically changed to take advantage that the application of the inverse square law to cancer radiation treatments would make.
Although Grimmett conceived of and published his ideas first, the Canadians built the first units because of the capability of their reactor to produce more suitable cobalt-60 sources.
The story tells how Grimmett and the other people involved came together at the time that the U S Atomic Energy Agency was pushing the use of radioactivity in medicine. But Grimmett died suddenly before his unit could be built and very little information about him was known until recently when various documents have come to light, allowing the full story to be told.

Proceedings of a workshop sponsored by the European Community and organized in Brussels, Belgium, October 1988 by the U. of Louvain Medical School, discuss problems related to the study of receptors and energy metabolism, particularly in relationship with the compartmental analysis and the modelling

Computed Tomography gives a detailed overview of various aspects of computed tomography. It discusses X-ray CT tomography from a historical point of view, the design and physical operating principles of computed tomography apparatus, the algorithms of image reconstruction and the quality assessment criteria of tomography scanners. Algorithms of image reconstruction from projections, a crucial problem in medical imaging, are considered in depth. The author gives descriptions of the reconstruction methods related to tomography scanners with a parallel X-ray beam, trough solutions with fan-shaped beam and successive modifications of spiral scanners. Computed Tomography contains a dedicated chapter for those readers who are interested in computer simulations based on studies of reconstruction algorithms. The information included in this chapter will enable readers to create a simulation environment in which virtual tomography projections can be obtained in all basic projection systems. This monograph is a valuable study on computed tomography that will be of interest to advanced students and researchers in the fields of biomedical engineering, medical electronics, computer science and medicine.

This book explores the physics, technology and applications of particle accelerators. It illustrates the interconnections between applications and basic physical principles, enabling readers to better understand current and upcoming technologies and see beyond the paradigmatic borders of the individual fields. The reader will discover why accelerators are no longer just toys for scientists, but have also become modern and efficient nuclear workhorses. The book starts with an introduction to the relevant technologies and radiation safety aspects of accelerating electrons and ions from several keV to roughly 250 MeV. It subsequently describes the physics behind the interactions of these particle beams with matter. Mathematical descriptions and state-of-the-art computer models of energy-loss and nuclear interactions between the particle beams and targets round out the physics coverage. On this basis, the book then presents the most important accelerator applications in science, medicine, and industry, explaining and comparing more than 20 major application fields, encompassing semiconductors, cancer treatment, and space exploration. Despite the disparate fields involved, this book demonstrates how the same essential technology and physics connects all of these applications.

Over the past two decades it has been increasingly recognized that whole-body ultrasound is an invaluable tool in the critically ill. In addition to offering rapid whole-body assessment, it has the advantage of being a bedside approach that is available at all times and can be repeated at will. Accordingly, it permits the immediate institution of appropriate therapeutic management. Whole-Body Ultrasound in the Critically Ill is the sequel to the author s previous books on the subject, which were first published in French in 1992 and 2002 and in English in 2004. This new volume reflects the latest state of knowledge by including a variety of improvements, revised definitions, and updated algorithms. Findings in respect of individual organs are clearly presented, and a particular feature is the in-depth coverage of the lungs, traditionally regarded as an area unsuitable for ultrasound. Throughout, the emphasis is on the practical therapeutic impact of the technique. Its value in a variety of settings, including unexplained shock, management of hemodynamic instability, acute respiratory failure (the BLUE protocol), and the critically ill neonate, is carefully explained. Interventional ultrasound and less widely recognized applications, such as mesenteric infarction, pneumoperitoneum, and intracranial hypertension, are also described. Pitfalls of the technique receive due attention. Today, whole-body ultrasound touches upon every area of critical care. This book, from the chief pioneer in the field, shows that the technique enables critical care physicians to detect therapeutically relevant signs easily and quickly. It will serve as an invaluable guide to the practice of a form of visual medicine."

This book provides an introduction to next generation smart screening technology for medical image analysis that combines artificial intelligence (AI) techniques with digital screening to develop innovative methods for detecting breast cancer. The authors begin with a discussion of breast cancer, its characteristics and symptoms, and the importance of early screening.They then provide insight on the role of artificial intelligence in global healthcare, screening methods for breast cancer using mammogram, ultrasound, and thermogram images, and the potential benefits of using AI-based systems for clinical screening to more accurately detect, diagnose, and treat breast cancer. Discusses various existing screening methods for breast cancer Presents deep information on artificial intelligence-based screening methods Discusses cancer treatment based on geographical differences and cultural characteristics

Pixel detectors are a particularly important class of particle and radiation detection devices. They have an extremely broad spectrum of applications, ranging from high-energy physics to the photo cameras of everyday life. This book is a general purpose introduction into the fundamental principles of pixel detector technology and semiconductor-based hybrid pixel devices. Although these devices were developed for high-energy ionizing particles and radiation beyond visible light, they are finding new applications in many other areas. This book will therefore benefit all scientists and engineers working in any laboratory involved in developing or using particle detection.

The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.