Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual Clinical Trials Methodology Workshop for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.

Featuring atypical cases and focusing on advanced imaging techniques, this book presents a compilation of unusual CNS pathologies with characteristic imaging findings. The aim is to aid the speedy diagnosis of otherwise rarely encountered clinical conditions and improve patient care. Presented as more than 130 real cases with extensive imaging description and step-by-step guidelines on how to diagnose individual pathologies, each scenario is backed by the most up-to-date literature available. The cases include some of the most recently described clinical conditions. The case-based format and description of each clinical journey encourages readers to engage with the diagnostic process and facilitates self-study. This book is for any radiologist who practices neuroradiology, neuroradiology fellows, neuroimaging fellows, practicing neurologist and neurology residents.

This book primarily focuses on the study of various neurological disorders, including Parkinson's (PD), Huntington (HD), Epilepsy, Alzheimer's and Motor Neuron Diseases (MND) from a new perspective by analyzing the physiological signals associated with them using non-linear dynamics. The development of nonlinear methods has significantly helped to study complex nonlinear systems in detail by providing accurate and reliable information. The book provides a brief introduction to the central nervous system and its various disorders, their effects on health and quality of life, and their respective courses of treatment, followed by different bioelectrical signals like those detected by Electroencephalography (EEG), Electrocardiography (ECG), and Electromyography (EMG). In turn, the book discusses a range of nonlinear techniques, fractals, multifractals, and Higuchi's Fractal Dimension (HFD), with mathematical examples and procedures. A review of studies conducted to date on neurological disorders like epilepsy, dementia, Parkinson's, Huntington, Alzheimer's, and Motor Neuron Diseases, which incorporate linear and nonlinear techniques, is also provided. The book subsequently presents new findings on neurological disorders of the central nervous system, namely Parkinson's disease and Huntington's disease, by analyzing their gait characteristics using a nonlinear fractal based technique: Multifractal Detrended Fluctuation Analysis (MFDFA). In closing, the book elaborates on several parameters that can be obtained from cross-correlation studies of ECG and blood pressure, and can be used as markers for neurological disorders.

A mainstay for radiology trainees and practitioners, Diagnostic Imaging: Genitourinary, Third Edition features an image-rich, reader-friendly format that outlines the role of imaging in diagnosing and managing diseases of the GU tract. Concise chapters and spectacular imaging examples combine to make this medical reference book an all-inclusive resource for every member of the radiology team. State-of-the-art imaging - such as CT urography, DECT, MR urography, and DWI MR - addresses the rapidly changing diagnostic algorithm used for evaluation of diseases of the genitourinary tract Presents approximately 2,500 superior images for a greater visual understanding, while bulleted text expedites reference and review Includes an expanded table of contents, updated chapters and references, and brand new illustrations that highlight the roles of MR and ultrasound for evaluating diseases of the GU tract Covers important hot topics such as prostate carcinoma staging and surveillance, adrenal adenoma work-up and relevance, staging and subclassification of renal cell carcinoma, and the role of DECT for renal stone characterization. Expert Consult eBook version included with purchase that offers access to all of the text, figures, images, and references on a variety of devices

In recent years the field of regional anesthesia, in particular peripheral and neuraxial nerve blocks, has seen an unprecedented renaissance following the introduction of ultrasound-guided regional anesthesia. This comprehensive, richly illustrated book discusses traditional techniques as well as ultrasound-guided methods for nerve blocks and includes detailed yet easy-to-follow descriptions of regional anesthesia procedures. The description of each block is broken down into the following sections: definition; anatomy; indications; contraindications; technique; drug choice and dosage; side effects; potential complications and how to avoid them; and medico-legal documentation. A checklist record for each technique and a wealth of detailed anatomical drawings and illustrations offer additional value. Regional Nerve Blocks in Anesthesia and Pain Medicine provides essential guidelines for the application of regional anesthesia in clinical practice and is intended for anesthesiologists and all specialties engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.

Medical students preparing for a career in clinical practice must become familiar with a wide range of diagnostic imaging techniques and image-guided interventions. They must learn to identify the indications for radiological examination and recognize the role each procedure plays in the workup, diagnosis, and therapeutic management of patients. That is why Squire's Fundamentals of Radiology has been such an important, long-standing resource for medical students, physicians, and other professionals at all stages of their careers. It teaches essential topics in the radiology curriculum and features hundreds of illustrative cases clinicians can turn to again and again in practice. In this long-awaited seventh edition, Robert Novelline provides more than 600 new high-resolution images representing the current breadth of radiological procedures: conventional x-rays, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), angiography, radioisotope scanning, positron emission tomography (PET), and molecular imaging. This edition's expanded coverage addresses dual energy CT, breast tomosynthesis, PET-MR scanning, and tractography brain imaging, along with best practices for managing patient experiences during and after examination. All new images were produced at a major teaching hospital using state-of-the-art imaging technologies. Squire's Fundamentals of Radiology is designed to be read cover to cover by students, with concepts, principles, and methods progressing in a logical, cumulative manner. It also serves as an invaluable tool for teachers and an indispensable reference for seasoned practitioners. Written by a radiologist who has trained thousands of medical students and residents, this textbook is the clear choice for excelling in the general practice of radiology.

Now entering its fourth edition, the market-leading Handbook of MRI Technique has been fully revised and updated to incorporate new technologies and developments essential to good practice. Written specifically for technologists and highly illustrated, it guides the uninitiated through scanning techniques and helps more experienced technologists to improve image quality. The first part of the book considers the main aspects of theory that relate to scanning and also includes practical tips on gating, equipment use, patient care and safety, and information on contrast media. The second half provides step-by-step instruction for examining each anatomical area, beginning with a basic anatomy section followed by sections on indications, patient positioning, equipment, artefacts and tips on optimizing image quality. Written by an international team of technologists from the United States, United Kingdom and Europe Suitable for users for all types of MRI systems Now includes key points throughout for quick reference Companion website at www.wiley.com/go/westbrook/mritechnique with self-assessment and image flashcards Handbook of MRI Technique continues to be the ideal support both for radiographers new to MRI and for regular users looking for information on alternative techniques and suggestions on protocol modifications.

This book clearly explains the basics of cranial ultrasonography in the neonate, from patient preparation through to screening strategies and the classification of abnormalities. The aim is to enable the reader consistently to obtain images of the highest quality and to interpret them correctly. Essential information is provided both on the procedure itself and on the normal ultrasound anatomy. The standard technique is described and illustrated, and emphasis is placed on the value of supplementary acoustic windows. Attention is also drawn to maturational changes in the neonatal brain and to the limitations of cranial ultrasonography. Frequently occurring abnormalities are described and classifications for these abnormalities are provided. A new classification for neonatal cerebellar hemorrhages is introduced. In this third edition, all ultrasound images have beena replaced, reflecting the improvements in image quality. An entirely new chapter is devoted to Doppler ultrasonography. The illustrations have been improved and new illustrations were added. The reader will have access to highly informative videos on the cranial ultrasound procedure, available online via SpringerLink. The compact design of the book makes it an ideal and handy reference that will guide the novice in understanding the essentials of the technique while also providing useful information for the more experienced practitioner.

Written with the radiography student in mind, Digital Radiography and PACS, 3rd Edition addresses today's digital imaging systems, including computed radiography (CR), digital radiography (DR), and picture archiving and communications systems (PACS). This new edition incorporates the latest technical terminology and has been updated to reflect the 2017 ASRT Core Curriculum guidelines. It includes tips on acquiring, processing, and producing clear radiographic images, performing advanced image processing and manipulation functions on CR/DR workstations, storing images with PACS workstations, and a guide to quality control and management. Coauthored by radiography educators Christi Carter and Beth Veale, this text is designed to help you produce clear radiographic images and learn to provide safe archiving solutions. Coverage of digital imaging and PACS is provided at the right level for student radiographers and for practicing technologists transitioning to digital imaging. Chapter outlines, learning objectives, and key terms at the beginning of each chapter introduce the chapter content, and help you organize study and boost comprehension. Bulleted summaries recap the main points of each chapter, ensuring that you focus on the most important concepts. Review questions at the end of the chapters are linked to the chapter objectives and help you assess your understanding of the material. NEW! Latest information on digital imaging systems includes computed radiography (CR), digital radiography (DR), and picture archiving and communications systems (PACS) as well as the data required by practicing technologists who are transitioning to digital imaging. NEW! Updated guidelines reflect the 2017 ASRT Core Curriculum. NEW! Latest technical terminology incorporated throughout the text. NEW! Streamlined technical concepts help you understand and digest complicated material. NEW! Chapter focuses specifically on medical informatics in radiography

Since it was first published, Accident and Emergency Radiology: A Survival Guide has become the classic in-my-pocket-reference and an indispensable aid to all those who work in the Emergency Department. The core and substantial value lies in the step-by-step analytical approaches which help you to answer this question: "These images look normal to me, but . . . how can I be sure that I am not missing a subtle but important abnormality?" "This book will provide essential reading and support to A&E trainees, medical students, radiology trainees, reporting radiographers and clinical nurse specialists, all of whom may be faced with trauma cases requiring accurate diagnosis and treatment." Reviewed by: RAD Magazine Feb 2015 "... Very nearly flawless...contains just the right amount of information to accommodate readers from trainees through to consultant or attending level." Reviewed by African Journal of Emergency Medicine , Jun 2015 Ensure accuracy in reading and interpretation of any given image. Common sources of error and diagnostic difficulty are highlighted. Prevent mistakes. Pitfalls and associated abnormalities are emphasized throughout. Avoid misdiagnoses. Normal anatomy is outlined alongside schemes for detecting variants of the norm. Each chapter concludes with a summary of key points. Will provide a useful overview of the most important features in diagnosis and interpretation. Easily grasp difficult anatomical concepts. Radiographs accompanied by clear, explanatory line-drawings. Spend less time searching with an improved layout and design with succinct, easy-to-follow text. A templated chapter approach helps you access key information quickly. Each chapter includes key points summary, basic radiographs, normal anatomy, guidance on analyzing the radiographs, common injuries, rare but important injuries, pitfalls, regularly overlooked injuries, examples, and references. Grasp the nuances of key diagnostic details. Updated and expanded information, new radiographs, and new explanatory line drawings reinforce the book's aim of providing clear, practical advice in diagnosis. Avoid pitfalls in the detection of abnormalities that are most commonly overlooked or misinterpreted. Access the complete contents and illustrations online at Expert Consult-fully searchable!

This book explains every aspect of the role of radiographers in performing CT colonography (CTC) and interpreting CTC images with the aim of enabling radiographers to extend the scope of their practice. It provides all the information required with respect to procurement of informed consent, principles of CT and radiation dose, patient preparation and positioning, the use of contrast media, the performance of diagnostic and screening CTC studies, and the interpretation and reporting of images. A wide range of CTC findings are described and depicted, covering normal anatomy, artifacts, hemorrhoids, polyps, colon cancer, diverticular disease, lipomas, and extracolonic structures. In addition, a chapter focusing on self-assessment of image interpretation will aid learning. The rising number of CTC studies for colon disorders is adding to an already burdened radiology workload. To reduce this workload, radiographers will increasingly be given responsibility to carry out CTC examinations and this book will provide the support that they need in order to perform CTC studies to the standard required.

This book is the ultimate reference on patent foramen ovale (PFO), a defect in the septum of the heart estimated to be present in more than twenty percent of the adult population and a proven cause of systemic embolism. All chapters have been written by internationally recognized experts in the field and cover PFO genetics and anatomy in addition to the effect PFO can have on various different organs and its supposed involvement in several conditions and clinical syndromes such as migraine, diving incidence, platynea orthodeoxia, economy class syndrome, sleep apnea and persistent desaturations in mild right ventricular dysfunction. As PFO anatomy varies significantly between individuals, chapters have also been included on the diagnostic tools, methods and techniques for appropriate assessment, detection and characterization of PFO. Furthermore, the multitude of available closure devices and techniques for PFO closure are discussed together with current and ongoing trial data. The book concludes with guidance and instruction on establishing a successful PFO program. Patent Foramen Ovale will be an essential text for the whole adult and pediatric interventional community, general cardiologists, internists, primary care physicians, neurologists and device companies in addition to medical students, graduate students and fellows in training.

Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement.

This completely revised and extended second edition: " "Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents.Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations.Is written for all of those involved in the development and application of contrast agents in MRI.Presented in colour, it provides readers with true representation and easy interpretation of the images.

A word from the Authors:

"Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms."

"Reviews of the First Edition: "

..".attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."--Journal of the American Chemical Society..".well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."--NMR in Biomedicine

During the past decade, the medical and surgical treatment of ulcerative colitis has undergone dramatic advances, including the widespread use of immunomodulators, biological drugs, and restorative proctocolectomy. In order to correctly balance the risks and benefits of medical therapies and surgical procedures, there is a need for improved diagnosis of colonic disease, acute complications, extraintestinal manifestations, and early and delayed postoperative complications. Cross-sectional imaging techniques are therefore playing an increasing role in the assessment of ulcerative colitis and provide an essential complement to clinical data and endoscopy. This practical, illustrated volume on the role of cross-sectional imaging is aimed at radiologists, gastroenterologists, and surgeons who are engaged or interested in the diagnosis and care of patients with inflammatory bowel disease, particularly ulcerative colitis. After an overview of diagnostic imaging techniques, state-of-the-art assessment of colorectal inflammatory disease with CT colonography using water enema is discussed, followed by description of the plain radiographic and CT findings in patients with acute exacerbations and surgical complications. Subsequent chapters review the diagnostic findings and role of cross-sectional imaging in the assessment of sclerosing cholangitis (with emphasis on MR cholangiopancreatography), vascular complications (particularly portal and mesenteric thrombosis), associated neoplasms, such as colorectal cancer and abdominal desmoids, and perianal inflammatory disease. Normal postoperative appearances and early and delayed complications in patients treated with proctocolectomy and ileal pouch-anal anastomosis are also comprehensively reviewed. "

Most postgraduate examinations now include radiographic interpretation. This may be presented as a slide show of as a film-viewing session. Radiographs and other imaging modalities are also used ubiquitously in the viva section of most such examinations including those of the American Boards and professional societies and universities worldwide. This series of Clinical Film Viewing will assist candidates to prepare for this process. Each book examines a particular system or technique followed by profusely illustrated cases typical of those presented in postgraduate examinations. The Cardiovascular System is aimed at candidates for postgraduate examinations in all specialties and especially those doctors with some training in cardiovascular disease who need to assess their knowledge of the subject. This book is particularly applicable to candidates for postgraduate examinations in radiology.

This fully revised new edition of a popular practical guide provides a concise introduction to radiology in neonates, covering the full range of problems likely to be encountered in the neonatal ICU. The material is presented in atlas format, with concise text descriptions to provide a quick overview of the indications, utility, appearances and interpretation of images of common neonatal pathology. Numerous high-quality images enable easy 'matching' with clinical cases faced by the reader. New to this edition: * Images updated throughout to reflect improvements in equipment and scanning techniques * Expanded chapters on cardiovascular problems, bone and prenatal ultrasound * New chapters on clinical utility of procedures, metabolic and inborn errors of metabolism, and antenatal diagnosis of common abnormalities Concise and practical, this is an essential training resource for all those who work in the neonatal ICU, including pediatric residents and trainees, junior radiologists and nurse practitioners.

This book provides a 2015 state of the art update on the hot topic of focal prostate cancer therapy, which offers a means of preserving the prostate and avoiding major side-effects associated with conventional treatment strategies. In so doing, focal therapy meets the desire of many patients, especially those with low-risk disease, to avoid or postpone radical therapies in order to preserve quality of life. A wide range of aspects are covered, including the role of imaging-guided targeted biopsies, the pros and cons of surveillance in comparison with focal therapy, focal hemiablation and focal salvage therapy, multifocal therapies, focal cryotherapy. The potential role of various new diagnostic technologies as well as specific therapeutic devices as "Focal.One" robotic high-intensity focused ultrasound are explained. The authors are all international experts who are long-term proponents of non-invasive treatment of prostate cancer. "Focal Therapy of Prostate Cancer" will be an invaluable source of information for urologists, oncologists, radiation oncologists, and general practitioners, and also for patients wishing to learn more about this new treatment option.

This book offers concise descriptions of cross-sectional imaging studies of the abdomen and pelvis, supplemented with over 1100 high-quality images and discussion of state-of-the-art techniques. It is based on the most common clinical cases encountered in daily practice and uses an algorithmic approach to help radiologists arrive first at a working differential diagnosis and then reach an accurate diagnosis based on imaging features, which incorporate clinical, laboratory, and other underlying contexts. The book is organized by anatomical organ of origin and each chapter provides a brief anatomical background of the organ under review; explores various cross-sectional imaging techniques and common pathologies; and presents practical algorithms based on frequently encountered imaging features. Special emphasis is placed on the role of computed tomography (CT) and magnetic resonance imaging (MRI). In addition to algorithmic coverage of many pathological entities in various abdominopelvic organs, unique topics are also examined, such as imaging of organ transplant (including kidney, liver and pancreas), evaluation of perianal fistula, and assessment of rectal carcinoma and prostate carcinoma by MRI. Cross-Sectional Imaging of the Abdomen and Pelvis: A Practical Algorithmic Approach is a unique and practical resource for radiologists, fellows, and residents.

This book is especially focused on the surgical aspect on Gender Dysphoria. Male to female surgery is widely discussed as well as the female to male conversion. Full information on hormone administration and surgical procedures are provided. Mental health issues are also described, as well as ethics, the law and psychosocial issues. The text is extensively referenced and includes numerous photos, tables and figures to clearly illustrate information. Based on collaboration between international experts in transgender health, this book is an essential guide for health care professionals, educators, students, patients and patients' families concerning the psychological, hormonal, surgical and social support of transgender individuals.

This handbook provides step-by-step instructions enabling even a novice in the field of interventional neuroradiology/endovascular neurosurgery to perform a procedure. It covers the breadth of mainstream endovascular techniques. This manual provides lucid, readily accessible and pertinent hands-on information. It focuses on practicalities such as technique, choice of equipment and rationale, contrast agents, medications, precise pre- and post-procedure management and management of complications. It does not elaborate on theoretical aspects of disease e.g., etiology, pathogenesis, statistics, etc. In essence, it provides the necessary information to enable performance of a procedure. Handbook of Neuroendovascular Techniques will be a great resource for a whole range of physicians from residents, to those just embarking on their own independent practice to established experts reviewing methodology of a technique. The authors have a depth of experience and are highly qualified, ensuring objective, pertinent, authoritative and competent coverage of subject matter.

This up-to-date textbook comprehensively reviews all aspects of cardiac CT and MRI and demonstrates the value of these techniques in clinical practice. A wide range of applications are considered, including imaging of atherosclerotic and non-atherosclerotic coronary artery disease, coronary revascularization, ischemic heart disease, non-ischemic cardiomyopathy, valvular heart disease, cardiac tumors, and pericardial disease. The numerous high-quality images illustrate how to interpret cardiac CT and MRI correctly for the purposes of diagnosis, treatment planning, and follow-up. Helpful summarizing sections in every chapter will facilitate rapid retrieval of information. This book will be of great value to radiologists and cardiologists seeking a reliable guide to the optimal use of cardiac CT and MRI in real clinical situations. An additional feature is the provision of QR codes allowing internet access to references, further figures, and motion pictures. The reader will be able to enjoy this book using a smartphone or tablet PC.

This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy, and chemotherapy. Normal and pathological findings are displayed in detailed MR images that illustrate the potential modifications due to treatment. Particular emphasis is placed on characteristic appearances on the newer functional MR imaging techniques, including MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. These techniques are revolutionizing neuroradiology by going beyond the demonstration of macroscopic alterations to the depiction of preceding metabolic changes at the cellular and subcellular level, thereby allowing earlier and more specific diagnosis. A key section comprising some 40 clinical cases and more than 500 illustrations offers an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, radiotherapists, and medical oncologists.

Since the first edition of this book was published, much new knowledge has been gained on hemangiomas and vascular malformations. This revised and updated second edition, written by worldwide leaders in the field, fully reflects this progress. Important improvements in the treatment of hemangiomas are reviewed, including the use of beta-blockers and other medical therapies as well as advances in interventional treatments and the treatment of hemangiomas in specific locations. Vascular malformations are being investigated with increasing frequency all over the world and new challenges are emerging regarding both diagnosis and treatment. This edition considers the current role of the full range of diagnostic imaging techniques -magnetic resonance imaging, computed tomography, nuclear medicine techniques, angiography, and phlebography. The various treatment options, including laser, interventional radiological, and surgical techniques, are then presented in detail. A further individual section is devoted to the study and treatment of lymphatic malformations and dysplasias, and a series of chapters also focus on problems in the treatment of malformations in particular locations, including the thorax and viscera. This book, in atlas format, is exceptional in providing clinically relevant information on the diagnosis and treatment of both hemangiomas and vascular malformations. It will appeal to all professionals who encounter these conditions in their daily clinical practice.

Radiology Illustrated: Hepatobiliary and Pancreatic Radiology is the first of two volumes that will serve as a clear, practical guide to the diagnostic imaging of abdominal diseases. This volume, devoted to diseases of the liver, biliary tree, gallbladder, pancreas, and spleen, covers congenital disorders, vascular diseases, benign and malignant tumors, and infectious conditions. Liver transplantation, evaluation of the therapeutic response of hepatocellular carcinoma, trauma, and post-treatment complications are also addressed. The book presents approximately 560 cases with more than 2100 carefully selected and categorized illustrations - along with key text messages and tables - that will allow the reader easily to recall the relevant images as an aid to differential diagnosis. At the end of each text message, key points are summarized to facilitate rapid review and learning. In addition, brief descriptions of each clinical problem are provided, followed by both common and uncommon case studies that illustrate the role of different imaging modalities, such as ultrasound, radiography, CT, and MRI.