Ideal for classroom use and self-study, this book explains the implementation of the most effective modern methods in image analysis, covering segmentation, registration and visualisation, and focusing on the key theories, algorithms and applications that have emerged from recent progress in computer vision, imaging and computational biomedical science. Structured around five core building blocks - signals, systems, image formation and modality; stochastic models; computational geometry; level set methods; and tools and CAD models - it provides a solid overview of the field. Mathematical and statistical topics are presented in a straightforward manner, enabling the reader to gain a deep understanding of the subject without becoming entangled in mathematical complexities. Theory is connected to practical examples in x-ray, ultrasound, nuclear medicine, MRI and CT imaging, removing the abstract nature of the models and assisting reader understanding, whilst computer simulations, online course slides and a solution manual provide a complete instructor package.

MR perfusion imaging is an area of major research interest and rapid clinical growth. Clinical Perfusion MRI: Techniques and Applications provides a concise and comprehensive review of the principles and applications of the field, covering dynamic susceptibility contrast, dynamic contrast enhancement, and arterial spin labeling imaging techniques. Principles of blood-volume and oxygenation imaging are included. The clinical applications of perfusion imaging in neurological disease and neuroscience are discussed - major topics including its use in imaging cerebrovascular disease and brain tumors and other neurological and neurodegenerative disorders. Non-neurologic applications are also covered with chapters on cardiac disease, breast cancer and other organ systems. Use of MR perfusion imaging in pediatrics is also discussed. Throughout the book case reports are included illustrating representative clinical examples. This book will be of interest to any clinician who uses MR perfusion imaging in their clinical practice, as well as researchers in the field of MRI.

Multiauthored book dealing comprehensively with the various aspects of imaging of pediatric musculoskeletal trauma. The work is subdivided in three main sections: Overview of lesions; Imaging of traumatic injuries according to body region; typical traumatic injuries of early infancy. The third section includes also legal aspects of child abuse (battered child) and will indicate current international medical-legal guidelines. The didactical approach and the wide-ranging account of the subject makes the book particularly valuable to practitioners from various disciplines, involved in diagnosis and management of trauma of pediatric bone and joint

Endovascular intervention - using medication and devices introduced through catheters or microcatheters placed into the blood vessels through a percutaneous approach - has emerged as a relatively new minimally invasive approach to treat cerebrovascular disease and possibly intracranial neoplasms. This textbook provides a comprehensive review of principles pertinent to endovascular treatment of cerebrovascular diseases and intracranial tumors, with a detailed description of techniques for these procedures and periprocedural management strategies. Particular emphasis is placed on expert interpretation of the quality of evidence provided and implications for practice related to endovascular procedures. This will be essential reading for clinicians working in interventional neurology and cardiology, endovascular neurosurgery, vascular surgery and neuroradiology.

This fully updated and expanded second edition of a successful book reviews the most important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the tests. Several clinicians and research workers, who have been at the forefront in developing the tests in question, provide clear practical guidance on the scope of each test, use in research, as well as an analysis of their accuracy and limitations. The international contributors have brought together a concise and practical guide on the role of neuropsychological testing to support the dementia assessment. Neuropsychological Assessments of Dementia in Down Syndrome and Intellectual Disabilities, Second Edition is an essential reference for all those working in the field of dementia and intellectual disabilities.

Sitting an accreditation examination is a daunting prospect for many trainee echocardiographers. And with an increasing drive for the accreditation of echocardiography laboratories and individual echocardiographers, there is a need for an all-encompassing revision aid for those seeking accreditation. The editors of this unique book have produced the only echocardiography revision aid based on the syllabus and format of the British Society of Echocardiography (BSE) national echocardiography accreditation examination and similar examinations administered across Europe. Written by BSE accredited members, fully endorsed by the BSE, and with a foreword by BSE past-president, DR. Simon Ray, this indispensable guide provides a valuable insight into how echocardiography accreditation exams are structured. Crucially, to support students with the more challenging video section of the exam, a companion website provides video cases, and with clear and concisely-structured explanations to all questions, this is an essential tool for anyone preparing to sit an echocardiography examination.

Written by one of the world's most respected cardiologists and designed with the needs of the internist and general clinical cardiologist in mind, this new volume provides clear, accessible guidance on the use of electrocardiography to diagnose and manage cardiovascular disease.

The Handbook of Mathematical Methods in Imaging provides a comprehensive treatment of the mathematical techniques used in imaging science. The material is grouped into two central themes, namely, Inverse Problems (Algorithmic Reconstruction) and Signal and Image Processing. Each section within the themes covers applications (modeling), mathematics, numerical methods (using a case example) and open questions. Written by experts in the area, the presentation is mathematically rigorous. This expanded and revised second edition contains updates to existing chapters and 16 additional entries on important mathematical methods such as graph cuts, morphology, discrete geometry, PDEs, conformal methods, to name a few. The entries are cross-referenced for easy navigation through connected topics. Available in both print and electronic forms, the handbook is enhanced by more than 200 illustrations and an extended bibliography. It will benefit students, scientists and researchers in applied mathematics. Engineers and computer scientists working in imaging will also find this handbook useful.

Neurointervention is a fast-growing subspecialty, and recent trials have demonstrated its role in ischaemic and haemorrhagic stroke. This has generated tremendous interest among interventional neuroradiology, neurology and neurosurgery communities. Nevertheless, formal teaching programmes that provide the required experience are limited, and many early career practitioners are not exposed to the crucial technical details essential to safely performing the procedure before they start practising independently. The book presents 100 characteristic case studies to illustrate the salient technical and clinical issues in decision-making and problem solving during the procedure. This book conveys the "real-world" issues and solutions that are not addressed in detail in most books. As such it is a practical teaching book with useful "tips and tricks" on how to handle specific challenging situations, and is particularly useful for fellows in neurointervention training programmes..

Drug-resistant epilepsy with negative MRI is frequently seen in patients considered for epilepsy surgery; however, clinical evaluation and surgical treatment is very complex and challenging. Advanced imaging techniques are needed to detect the location of the epileptogenic zone. In most cases, intracranial EEG recording is required to delineate the region of seizure onset - this carries some risks of major complications. Moreover, the borders between the recorded seizure onset and the location of important brain functions are often indistinct in MRI-negative epilepsy. Overall, the outcome of MRI-negative surgery is less favorable than that of MRI-positive surgery, but it can significantly improve with optimal management. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery. Authors critique evidence and share their expertise on the diagnostic options and surgical approaches that make epilepsy surgery possible and worthwhile in patients with this condition.

You already have the most comprehensive and authoritative radiography text available -- now make sure you're getting the most out of it! The Workbook for Merrill's Atlas of Radiographic Positioning and Procedures, 12th Edition, provides plenty of practice and review of concepts presented in the atlas, helping you learn faster and retain essential information. Authors Eugene Frank, Bruce Long, Barbara Smith, and Jeannean Hall Rollins concentrate on the essential terminology, anatomy, and positioning information needed to ensure that you'll be ready to take the ARRT exam and be thoroughly prepared for the clinical environment. Correlation with main Merrill's Radiographic Atlas features exercises that support the digital positioning content in the atlas. Wide variety of exercises holds user's interest and provides a variety of interaction with the content. Exercises on identifying errors on radiographs prepare users to evaluate radiographs in clinical situations. Anatomy and positioning exercises provide balanced coverage of both topics. Abundance of labeling exercises ensures users recognize anatomical structures on actual radiographs. Comprehensive self-test at the end of each chapter enable users to accurately gauge their comprehension of the material and measure their own progress. Pathology exercises helps users understand which projections will best demonstrate various pathologies. NEW! New images reflect all the content updates in the main Merrill's text. NEW! Detailed review exercises that cover osteology, anatomy, physiology, arthrology and radiographic examinations NEW! Additional images for identifying essential projections

This book, now in its second edition, remains one of very few works devoted to pediatric musculoskeletal imaging since the advent of cross-sectional methods, and the only one - to the best of our knowledge - specifically dedicated to the skeletally immature joint and its diseases. There has been a steady decline in the number of pediatric radiologists, and less emphasis has been given to pediatric training for general radiologists, so that the latter are more and more unfamiliar with normal and abnormal imaging findings in children and adolescents. This can lead to the misinterpretation of normal findings and failure to recognize abnormal exam results. Even though this book is intended primarily for radiologists, it will also greatly benefit general rheumatologists, pediatric rheumatologists, pediatricians, orthopedic surgeons and all those involved in the diagnosis and treatment of children and adolescents with articular complaints. It employs simple and accessible language, so that it provides the in-depth information required by radiologists, while still being understandable for non-radiologists. Although its structure is fluent and logical, the chapters are all self-contained. Richly illustrated, its imagery combines the pictorial strength of old radiographs, which display late-stage abnormalities rarely seen today, and the appeal of modern imaging and its ability to detect early signs and subtle findings. Key points are summarized at the end of each chapter. By presenting essential information on imaging of the immature joint, the authors hope to provide a useful tool to help radiologists (musculoskeletal specialists and generalists alike) face the daily challenges of interpreting pediatric exams. Soon, artificial intelligence (AI) will be able to perform the most basic radiological diagnoses. Nevertheless, pediatric musculoskeletal radiology is complex and full of facets, and mastering this area in this ever-changing time can be a very important differential in the career of the 21st century radiologist.

In today's healthcare environment, the real driver is value. Maximizing outcomes and minimizing costs or providing similar outcomes with lower cost in terms of actual numbers or recovery time will dominate our healthcare delivery system. An excellent example of this evolution is in the ?eld of cardiovascular intervention. Dr. Jacques Kpodonu's Manual of Thoracic Endo-Aortic Surgery is a most timely and descriptive work in this burgeoning ?eld. It provides an excellent overview of current technology and techniques, plus the endovascular expert can drill down into the details of the devices and technologies described and signi?cantly enhance their knowledge and perspective. Procedural detail, excellent graphics, pertinent imaging studies, and relevant instruction are the mainstays of this text. The ?rst chapter comprises the key overview and very comprehensively covers the platform - the hybrid OR, the tools, the accessories, and the medium - superb, state-of-the-art imaging modalities required to perform these advanced procedures. The text then moves into more technical details including options and instruction regarding access approaches and potential pitfalls of such. This is followed in en- ing chapters by dissemination of precise information, techniques, and indications for the most popular and utilized grafts including Boston Relay Stent Graft, Cook TX2 Zenith Stent Grafts, as well as the Gore and Medtronic Aortic Stent Grafts.

This book provides detailed information on functional anatomy, physical examination, and clinical radiology of the shoulder with a view to enabling the clinician to identify the most suitable treatment approach to different shoulder joint pathologies. In addition, it describes the arthroscopic treatment techniques most frequently employed in patients with these conditions and presents numerous arthroscopic images detailing characteristic findings. The shoulder is widely regarded as the most complex joint in the human body, displaying the widest range of motion. Knowledge of normal and pathological anatomy, ability to perform a proper physical examination, and appropriate selection of imaging modalities and interpretation of imaging appearances, often in close collaboration with an imaging expert, are all vital for correct diagnosis and choice of treatment approach. Surgeons and trainees will find this richly illustrated book to be an excellent educational guide and an instructive source of stepwise guidance from clinical presentation to achievement of desired treatment outcomes.

This book addresses the wide range of issues that face the program leader - from how to choose a site and how to negotiate for equipment, to how to determine staffing requirements and how to anticipate and defuse possible turf issues with other programs and services in the hospital or healthcare facility. The early chapters of this book focus on the leadership of your program whether in your department or institution. The second section centers on education at all levels recognizing that smaller machines have made ultrasound available for medical students to advanced practitioners. The third section provides detailed logistics on equipment, maintenance, and safety. The fourth section focuses on a quality improvement program and includes a chapter on the workflow process. For those with limited budgets we also offer a section on practical operating and educational solutions. The fifth section offers insight into hospital level credentialing, quality assurance, national politics, and recent issues with accreditation. This is followed by reimbursement and coding. The last section covers topics in specialized communities. Chapters focus on ultrasound in global health, emergency medical services, pediatrics, critical care, community and office based practices. Multiple US working documents including checklists, graphs, spreadsheets, tables, and policy appendices are included.

Head and Neck Imaging, by Drs. Peter M. Som and Hugh D. Curtin, delivers the encyclopedic and authoritative guidance you've come to expect from this book - the expert guidance you need to diagnose the most challenging disorders using today's most accurate techniques. New state-of-the-art imaging examples throughout help you recognize the imaging presentation of the full range of head and neck disorders using PET, CT, MRI, and ultrasound. Enhanced coverage of the complexities of embryology, anatomy, and physiology, including original color drawings and new color anatomical images from Frank Netter, help you distinguish subtle abnormalities and understand their etiologies. Access to the complete book's contents is available online at www.expertconsult.com, which allows you to compare its images onscreen with the imaging findings you encounter in practice. Compare your imaging findings to thousands of crystal-clear examples representing every type of head and neck disorder.both inside the book and onscreen at www.expertconsult.com. Gain an international perspective from global authorities in the field. Find information quickly with a logical organization by anatomic region. Master the latest approaches to image-guided biopsies and treatments. Utilize PET/CT scanning to its fullest potential, including head and neck cancer staging, treatment planning, and follow up to therapy. Visualize head and neck anatomy better than ever before with greatly expanded embryology, physiology and anatomy content, including original drawings and new color anatomical images. Grasp the finer points of head and neck imaging quickly with more images, more detail in the images, and more anatomic atlases with many examples of anatomic variants. Access the complete content- and illustrations online at www.expertconsult.com - fully searchable! Accurately diagnose any head and neck disorder with expert guidance on the latest imaging techniques!

This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.

The main purpose of this book is to provide the reader with a better understanding of spinal nerve root injuries caused by various pathologies (e.g. disc herniation, space-occupying lesions, trauma etc.). The standard anatomical description of spinal nerve roots origin, course and arrangement (described in the first chapters of the book) is now strongly influenced by the frequent findings of their intraspinal extradural and intradural connecting branches and by other variations, which are considered to be the major cause of the surgical therapy failures. Intraspinal extradural and intradural neuroanatomical roots variations may affect in fact the clinical picture, diagnosis, and surgical treatment; their recognition can minimize the damage to neural structures in the spinal anaesthesia, in spinal operations, in spondylosurgery, in endoscopic surgery, laser discectomy, etc. Their aetiology is unknown and it has to be elucidated, and they are rarely found during the usual preoperational examinations, a reason that encouraged various anatomical dissection studies finalized to their description. The data shown in this book will be surely helpful for traumatologists, orthopaedists, spinal surgeons, neurosurgeons, plastic surgeons and for all those dealing with intraspinal variations of nerve roots.

Clinician-performed bedside ultrasound is an exciting new development in medicine. Numerous diagnostic and procedural applications show great promise for improving the care of children. Many pediatric providers, however, remain unaware of its potential and ultrasound continues to be under-utilized in both the investigation and management of ill and injured children. Case Studies in Pediatric Emergency and Critical Care Ultrasound illustrates the utility of bedside ultrasound in a variety of scenarios, including the emergency setting and critical care unit. A wide range of diagnostic and procedural applications are covered in fifty-nine cases, recreating real-life experiences of expert practitioners. The cases are concise and readable, with teaching points that highlight how ultrasound can be used to expedite and focus pediatric care. With hundreds of high-quality images, and video content accompanying many cases, this text is essential reading for pediatricians, emergency physicians, pediatric anesthesiologists and critical care physicians.

This book addresses the most important postnatal features of Zika virus infection, providing important information on its epidemiology, pathology, clinical aspects, imaging and laboratory diagnosis. Since the report of a Zika virus infection epidemic in Northeastern Brazil in 2015, the world has paid close attention to this emergent disease. Historically, this has been the third outbreak of Zika infection described (preceded by outbreaks in Micronesia and French Polynesia), but for the first time the association with congenital microcephaly and other neurological co-morbidities in infants from women infected with the Zika virus was observed. Since then, government bodies, public health agencies, medical societies and scholars have joined forces to understand this disease, and to promote its prevention and management. Currently, the relationship between Zika virus and microcephaly is well established, as well as the most characteristic findings of congenital Zika syndrome (e.g. microcephaly, arthrogryposis, ophthalmologic and hearing abnormalities). Also, the spectrum of the disease's severity has broadened, with less severe cases (without microcephaly) being recently recognized. Even so, there is currently a dearth of material on Zika virus infection for healthcare professional around the world. Addressing that gap, Zika In Focus - Postnatal Aspects aims to help the medical community worldwide by presenting the most important features of Zika virus infection from a postnatal perspective. It is intended to all professionals and researchers interested in this condition, especially paediatricians, radiologists and neurologists, offering them a practical guide to recognizing congenital Zika syndrome in its many aspects and focusing on the radiological pattern of lesions that can be found from the mild to the most severe cases.

With the recent development of new technology and practices in the field of ambulatory EEG (aEEG), the time is right for a practical reference on the application of aEEG in clinical practice. This authoritative guide to prolonged EEG recording outside the hospital or clinic is a valuable resource for anyone involved in long-term EEG monitoring and interpretation. Bridging the gap between routine scalp EEG and in-patient video EEG monitoring, aEEG has evolved to provide cost-effective, high-yield, high-tech recording for evaluation of epilepsy diagnoses, nonepileptic attacks, quantification of seizures or epileptiform burden, and other issues requiring extended EEG observation for paroxysmal neurological events in any environment.Bringing together top experts from leading epilepsy centers, the book covers equipment, technical aspects of recording, instrumentation and polygraphic event monitoring, artifacts, clinical use in adult and pediatric patients, sleep recording, short-term and chronic ambulatory EEG, and reimbursement. The concluding chapter offers representative case presentations with relevant findings to further enhance the reader's understanding and implementation of key concepts.This "start to stop" survey of current applications is essential reading for a wide range of clinicians practicing in the field of clinical neurophysiology and epilepsy management, whether seasoned or in training.Key Features:Fills the void of when and how to use aEEG in evaluating patients with paroxysmal neurological events and epilepsyIncorporates aEEG into clinical management at all stages of diagnosis and treatmentContains numerous aEEG illustrations and graphics to emphasize key pointsIncludes a chapter on common artifacts that can complicate the interpretation of an aEEGDetails the evolving use of chronic intracranial aEEG and wearable devicesIllustrative case studies provide pearls and reinforce best practices in aEEG monitoring

RADIOLOGIC TECHNOLOGY AT A GLANCE, 1st edition is an essential part of your journey from student to professional. Aligned with the five major content categories of the national ARRT exam, the text is designed to help clarify and explain imaging concepts and theories critical to the imaging profession. The user-friendly format promotes critical thinking and reinforces retention of material. Each chapter provides learning objectives, an overview of the concept, discussion of important terminology, formulas, and imaging practice, and includes hundreds of tables and illustrations. Practice exercises like matching, critical thinking, and retention of material exercises help reinforce major concepts and identify areas where more review may be needed. Accompanying software offers additional practice, including exam style review questions and a comprehensive audio pronunciation library. Whether you bring this text with you to class, use it as test preparation, or carry it on the job, you will find that RADIOLOGIC TECHNOLOGY AT A GLANCE clarifies and reinforces your understanding of critical concepts related to the imaging profession.

This book gives a clinical context to optical coherence tomography (OCT) findings, while considering the differential diagnosis and providing patient management guidance. Relevant anatomical and technical aspects are discussed, followed by a pragmatic illustration of the use of OCT for the clinical spectrum of multiple sclerosis and optic neuritis, and finishing with information on monitoring ocular side effects of recently approved disease-modifying treatments in multiple sclerosis. Optical Coherence Tomography in Multiple Sclerosis: Clinical Applications is aimed at clinical neurologists working with patients suffering from MS and general neurologists who see patients with visual symptoms in their daily practice. Ophthalmologists sharing clinical responsibilities with neurologists for patients under disease-modifying treatments will also find the book of interest.

Drawing together topics from a wide range of disciplines, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine. Internationally renowned researchers showcase topics ranging from the basic physical principles of magnetism to the detection and manipulation, synthesis protocols and natural occurrence of magnetic nanoparticles. Up-to-date examples of their clinical usage and research applications in the biomedical fields of sensing by diverse magnetic detection methods, in imaging by MRI and in therapeutic strategies such as hyperthermia, are also discussed, providing a thorough introduction to this rapidly developing field. Each chapter features questions with answers, highlighted definition boxes, and numerous illustrations which help readers grasp key concepts. Mathematical tools, together with key literature references, provide a strong underpinning for the material, making it ideal for graduate students, lecturers, medical researchers and industrial scientific strategists.

This detailed volume presents a number of chapters that will aid researchers in jumping the hurdle preventing the popularization of advanced intravital imaging technology usage, namely the complicated experimental protocols. Leading researchers undertaking imaging studies in the field of bone and immune systems have contributed the chapters that aim to guide readers through these complex methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Intravital Imaging of Dynamic Bone and Immune Systems: Methods and Protocols will serve as an idea guide for general readers in order to establish and perform these experiments by their own.