This issue provides a timely update on the use of ultrasound to image various organ systems as well as the musculoskeletal system.

This book contains the full papers presented at the MICCAI 2013 workshop Computational Methods and Clinical Applications for Spine Imaging. The workshop brought together researchers representing several fields, such as Biomechanics, Engineering, Medicine, Mathematics, Physics and Statistic. The works included in this book present and discuss new trends in those fields, using several methods and techniques in order to address more efficiently different and timely applications involving signal and image acquisition, image processing and analysis, image segmentation, image registration and fusion, computer simulation, image based modelling, simulation and surgical planning, image guided robot assisted surgical and image based diagnosis.

This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

Low- and middle-income countries have seen a dramatic rise in the incidence of breast and gynecological cancers in the past decade. Organized cancer screening programs are not widely available in developing countries, leading to disproportionately higher mortality rates compared to those in the developed world. This book addresses cost-effective strategies for implementing programs aimed at screening for the early detection of breast, cervical, endometrial, and ovarian cancers. A well woman clinic concept providing such services as part of women's health examinations is proposed, aiming to ensure patient compliance by limiting clinic visits required for initial testing and diagnosis of screen positive cases.

The Doppler principle is widely applied in astronomy, navigation, geodesy and a number of other disciplines of science and technology. Doppler sonography plays an increasingly important role in many fields of medicine - angiology, neurology, cardiology - an promises many exciting possibilities in the future. Yet, until recently, very little was known about the Austrian scientist whose name has been given to an established and routine medical examination. This book seeks to fill this gap and gives insight into the life of Christian Doppler, not only as a scientist, but also as a persona nd family man. It provides a wealth of new information and many new documents on the man who presented his famous paper "On the coloured light of the double stars" (which appears in facsimile with an English translation) in Prague 150 years ago this year.

This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses.

The second edition of Spectral Domain OCT is a practical guide to the investigation and diagnosis of retinal disease using the Topcon machine. Beginning with an overview of OCT, the book provides a step by step approach to image capture, analysis and interpretation. With the help of numerous case studies, OCT patterns in different types of retinal disease are ppresented as both 2D and 3D images. In addition, Spectral Domain OCT highlights features of the new Topcon 2000 machine with an enhanced speed of 27,000 A scans/second, improved software algorithms and extra facilities for anterior segment imaging.

Diffusion-weighted MR Imaging, Perfusion MR Imaging, and Diffusion Tensor Imaging provide information that is present in no other imaging modality. With Guest Editor Scott Reeder focusing on the body and Guest Editor Pratik Mukerjee exploring the neurological aspects of these three imaging modalities, this is a must-have resource for any radiologist involved in MR Imaging. It explores such subjects as: Diffusion weighted MR imaging in musculoskeletal radiology, Arterial Spin Labeled Perfusion Imaging, and Diffusion Tensor Imaging of Neurodegenerative Diseases.

New radiotracers will make possible the imaging of other parts of the body using PET. This issue reviews the latest advances and provides a look to the future of PET imaging.

Now that the applications of positron emission tomography (PET) are becoming more clearly understood, PET is now being used in pediatric population. Important considerations in its use on children are patient preparation and radiation exposure. This issue reviews the use of PET to image children with Hodgkin and non-Hodgkin lymphoma, brain tumors, and inflammatory bowel disease, among other conditions. Also included is the use of PET to assess response to therapy.

This issue takes a multimodality approach to imaging of osteoarthritis. Clinical issues including an overview of the disease and imaging as an aid to evaluate patient functionality are also reviewed. Not only are current standards for imaging covered but also newer techniques under development.

With the advent of combined modality imaging, it has become essential for the radiologists how structure and function relate to each other. Previously radiologists had to rely upon CT or MRI in order to tell the location of a problem but could not assess functionally what was going on within the patient. PET image has allowed radiologists to make a functional assessment to aid in the diagnosis and treatment planning for patients. This issue reviews the use of PET/CT and PET/MRI to evaluate patients with neurologic disorders, malignant and nonmalignant thoracic disorders, the cardiovascular system, breast diseases, musculoskeletal system, abdominal and pelvic disorders, and endocrine disorders.

Topics include: MR Imaging of the Pediatric Bone Marrow; The growing skeleton: MR appearances of developing cartilage; Infectious and Inflammatory Disorders; MRI of Pediatric Trauma; MRI of Pediatric Arthritis; MR Imaging of Primary Bone Tumors and Tumor-like Conditions in Children; MR Imaging of soft tissue masses in children; The hip: MR imaging of uniquely pediatric disorders; The knee: MR imaging of uniquely pediatric disorders; The foot and ankle: MR imaging of uniquely pediatric disorders; MRI in Congenital and Acquired Disorders of the Pediatric Upper Extremity.

A detailed description of up-to-date methods used for computer processing and interpretation of medical images is given. The scope of the book include images acquisition, storing with compression, processing, analysis, recognition and also its automatic understanding In introduction general overview of the computer vision methods designed for medical images is presented. Next sources of medical images are presented with their general characteristics. Both traditional (like X-ray) and very modern (like PET) sources of medical images are presented. The main emphasis is placed on such properties of medical images given by particular medical imaging methods which are important form the point of view of its computer processing, analysis and recognition. The consecutive parts of the book describe compression and processing methods, including many methods developed by authors especially for medical images. After parts describing analysis and recognition of medical images come most important part, in which the new method of automatic understanding of medical images is given. This new method of image interpretation, described in previous works of the same authors with applications for simple 2D images now is generalized for 3D images and for complex medical images with many objects observed and with complicated relations between these objects.

This issue takes a survey approach to the role of imaging of the musculoskeletal system. Starting with the role of conventional radio graphs, all modalities including MR, CT, ultrasound, and nuclear medicine are reviewed, as well as interventional applications, such as arthrography, radio frequency, and cryoablation of tumors.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Head and Neck, fourth edition, is an invaluable resource for neuroradiologists, general radiologists, and trainees-anyone who requires an easily accessible, highly visual reference on today's head and neck imaging. Dr. Philip R. Chapman and his team of highly regarded experts provide up-to-date information on recent advances in disease identification, imaging techniques, and tumor staging to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool as well as a handy reference for daily practice. Serves as a one-stop resource for key concepts and information on head and neck imaging, including a wealth of new material and content updates throughout Features more than 2,800 illustrations including radiologic images, full-color illustrations, clinical and gross pathology photographs, and histology photographs, as well as an additional 2,200 digital images online Features numerous new chapters and updates from cover to cover including changes to staging of HPV-related/p16(+) oropharyngeal squamous cell carcinoma; new metastatic disease imaging recommendations, protocols, and treatments; and the latest knowledge on the genetics of various congenital conditions and syndromes Reflects new Lugano and WHO classifications for staging lymphomas; updates in the AJCC Cancer Staging Manual, 8th Edition; and updates from the 2018 ISSVA Classification regarding avoidance of outdated and inappropriate terminology and nomenclature that can lead to misdiagnosis or inappropriate treatments Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Forensic anthropology deals with human remains usually in the skeletonized form. The application of microscopy to skeletal tissues is well established and used routinely in biomedical science. Its adaptation to forensic questions is an increasing area of interest, and publications utilizing microscopy have increased in the scientific literature. In Forensic Microscopy for Skeletal Tissues: Methods and Protocols, expert researchers in the forensic, archeological and paleontological disciplines, and detail many of the methods which are now commonly used to study skeletal material. These methods include differing forms of light, confocal, scanning electron and transmission electron microscopy. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Forensic Microscopy for Skeletal Tissues: Methods and Protocols bring together differing forms of microscopy that are used in association with forensic anthropology, or have relevance to questions concerning forensic anthropology.

Because of their constant use and intricate architecture, the foot and ankle can be the source of many problems. As a result, imaging is crucial for diagnostic purposes and so that treatment decisions can be made. This issue reviews imaging of soft-tissue lesions, osteochondral lesions, and metatarsalgia. Sonography of the hind and mid foot, Imaging of Lis Franc injury, and imaging of the diabetic pedal osteomyelitis are also covered among other topics.

This volume addresses the various techniques and novel applications of mass spectrometry imaging (MSI) and its role as a discovery tool in the field of proteomics, lipidomics, and metabolomics. The chapters in this book demonstrate how MSI can be applied to many areas of research such as clinical pathology, translational medicine, toxicology, biomarkers and response studies, and potential incorporation of MSI into forensic workflows. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Innovative and comprehensive, Imaging Mass Spectrometry: Methods and Protocols is a valuable resource for research scientists and clinicians who are interested in further studies of MSI technologies.

This book provides a complete overview of all modalities used for hand and wrist imaging, along with a complete overview of the various disease entities that can be diagnosed. As a state-of-the-art overview of hand and wrist imaging it is a reference work for radiologists, hand surgeons, orthopedists, traumatologists, rheumatologists and internists and their residents in training. The chapters are written by experts in musculoskeletal radiology from various European countries and the USA.

This book covers all the existing imaging modalities currently in use in imaging departments, providing a sound basis for understanding how individual systems work. It is designed to be accessible to students without minimising the content. Although conventional imaging is being phased out, it still exists in certain areas, e.g. dental surgeries, and therefore is reduced in size and placed in an Appendix. The text has been restructured in list form to increase clarity and aid study Pedagogic features include an introduction and summary for each chapter Glossaries of imaging terms and computer buzz words, and a key to commonly used abbreviations are included New edition is completely rewritten: Digital imaging is main focus CT, ultrasound, MRI and NMR imaging added 'Conventional' imaging retained as an Appendix Text simplified, and block diagrams, flow charts and tables added to increase accessibility of content