MRI has become an important tool in the management of patients with diseases of the gastrointestinal tract, such as rectal cancer and inflammatory bowel diseases. This book, written by distinguished experts in the field, discusses in detail the technical, practical, and clinical aspects of MRI of the gastrointestinal tract. The chapters on technique encompass the most recent developments and address such topics as contrast media, high field strength MRI, and perfusion MRI. Subsequently, individual chapters are devoted to the clinical applications of MRI in the different parts of the gastrointestinal tract. Both established applications and new frontiers are considered, with the aid of numerous high-quality illustrations. By combining chapters dedicated to technical aspects and clinically oriented chapters, this book will prove very instructive for the novice while simultaneously offering experienced practitioners further insights into the value of MRI of the gastrointestinal tract.

This book provides a detailed and comprehensive overview of the role of diagnostic imaging in the assessment and management of trauma and polytrauma in children. The coverage includes imaging of injuries to the head, thorax, abdomen, bone and musculoskeletal system, with careful attention to the newest imaging techniques, imaging during the course of recovery and imaging of complications. A series of illustrative cases underline the prognostic value of imaging. In addition, an individual chapter is devoted to diagnostic imaging in cases of child abuse. The book concludes by discussing informed consent and medicolegal issues related to the imaging of pediatric traumatic emergencies. "Imaging Trauma and Polytrauma in Pediatric Patients "will be invaluable in enabling radiologists and clinicians to identify the main features and signs of injuries on a wide range of imaging techniques, including X-ray, ultrasonography, computed tomography and magnetic resonance imaging.

Recent advances in technology have opened up new possibilities in the diagnosis and treatment of cerebrospinal vascular diseases. It is now possible to use magnetic resonance imaging to map brain function and metabolism as an aid to diagnosis. Novel applications of magnetic resonance angiography allow three-dimensional imaging, and the magnetization transfer contrast technique gives us a new window on cerebral vascular function. This volume presents work in all these fields as well as previewing the techniques of endovascular surgery for cerebrospinal vascular diseases. These include modern stereotactic radiosurgery for arteriovenous malformations and for angiographically occult vascular malformations of the brain. This book presents an overview of the latest applications of technology to this rapidly developing and challenging field.

The second edition of Spectral Domain OCT is a practical guide to the investigation and diagnosis of retinal disease using the Topcon machine. Beginning with an overview of OCT, the book provides a step by step approach to image capture, analysis and interpretation. With the help of numerous case studies, OCT patterns in different types of retinal disease are ppresented as both 2D and 3D images. In addition, Spectral Domain OCT highlights features of the new Topcon 2000 machine with an enhanced speed of 27,000 A scans/second, improved software algorithms and extra facilities for anterior segment imaging.

Cardiac ultrasound has rapidly developed into one of the most important clinical methods for diagnosis and follow-up of patients with heart disease and has changed the practice of cardiology permanently. In addition to improving image quality, most of the progress relies on digital image acquisition, storage, and quantitative analysis equipment. Automatic endocardial detection and three- dimensional reconstruction are now being developed. The progress with contrast echocardiography for myocardial perfusion imaging and results with tissue characterization is slow, but ever increasing, illustrating that the full potential of the method has not yet been explored. All of these digital techniques are extensively dealt with in this volume. Computerized tools will help the clinical cardiologists in their daily practice and stimulate further development to gen- uinely improve patient care in the coming years. We wish to thank the authors to this volume for their excellent contribution and Mrs. T. van der Kolk for secretarial assistance. IX Contributors F. J. ten Cate Thorax Center, Erasmus University, P. O. Box 1738, 3000 DR Rotterdam, The Netherlands R. Erbel II Medical Clinic, Johannes Gutenberg University, Langenbeckstr. 1, P. O. Box 3960, D-6500 Mainz, FRG Co-authors: R. Zotz, B. Henkel, G. Schreiner, C. Steuernagel, R. Zahn, H. Kopp, W. Clas, R. Brennecke, P. Schweizer, J. Meyer S. B. Feinstein Division of Cardiology, Box 44, University of Chicago, 950 East 59th Street, Chicago, IL 60637, USA D. G. Gibson Department of Cardiology, Brompton Hospital, Fulham Road, London SW3 6HP, UK Co-author: R. B. Logan Sinclair E.

The sixteen chapters included in this book were written by invited experts of international recognition and address important issues in Medical Image Processing and Computational Vision, including: Object Recognition, Object Detection, Object Tracking, Pose Estimation, Facial Expression Recognition, Image Retrieval, Data Mining, Automatic Video Understanding and Management, Edges Detection, Image Segmentation, Modelling and Simulation, Medical thermography, Database Systems, Synthetic Aperture Radar and Satellite Imagery.

Different applications are addressed and described throughout the book, comprising: Object Recognition and Tracking, Facial Expression Recognition, Image Database, Plant Disease Classification, Video Understanding and Management, Image Processing, Image Segmentation, Bio-structure Modelling and Simulation, Medical Imaging, Image Classification, Medical Diagnosis, Urban Areas Classification, Land Map Generation.

The book brings together the current state-of-the-art in the various multi-disciplinary solutions for Medical Image Processing and Computational Vision, including research, techniques, applications and new trends contributing to the development of the related areas.

The FRCR examination was recently changed and now comprises two modules: physics and radiological anatomy. The anatomy module is new, and consists of 20 radiological images, with 5 questions on each image, 100 questions in all. The anatomy examination lasts for 75 minutes and incorporates 20 separate images (cases) with 5 questions per case, producing a total of 100 questions. The cases will be presented at computer work-stations, with separate written answer sheets for completion. In this book we present 5 complete `mock' anatomy examinations, with a total of 500 questions. We have stayed true to the lay out of the RCR sample questions and answer sheets to ensure familiarity. The anatomical structures should not be ambiguous and, if necessary, there will be more than one arrow to indicate the appropriate structure (a concept that has been included in some of the example questions in this book). As a rule, the candidate should make an attempt to answer ALL questions in the exam as there is no negative marking. It is advised that answers be as complete as possible, for instance the use of `left' or `right' if this can be derived from the image, or rather than simply stating `acromion', use the `acromion process of the scapula' - if you have the knowledge, use it! This book should not be used as a primary revision tool, rather a practice aid to test the candidate against the clock in exam conditions and highlight any areas of weakness or imaging examinations that the candidate may be unfamiliar with. Primary revision is suggested by using traditional anatomy alongside radiology-based anatomy textbooks. It is also necessary to experience everyday radiological investigations, and even more specialist investigations, as essentially any type of radiological image can be used for assessment of anatomical knowledge in this examination. The authors provide explanatory answers, and have also included extra images to accompany their explanations. In addition there are references to key revision resources, and they have also given advice on exam technique. They have first hand experience of running courses on the new format FRCR anatomy exam, and are therefore the perfect authors for the subject. Key Points 100% relevant to the new format Authors run FRCR Part 1 courses 500 questions

This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a "toolbox" for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: * A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome * A pedagogical approach to the methodology * Engaging the reader and student with a clear, yet critical presentation of the applications

This book constitutes the Proceedings of the 26th Symposium on Acoustical Imaging held inWindsor, Ontario, Canada during September 9-12, 2001. This traditional scientific event is recognized as a premier forum for the presentation of advanced research results in both theoretical and experimental development. The lAIS was conceived at a 1967Acoustical Holography meeting in the USA. Since then, these traditional symposia provide an opportunity for specialists who are working in this area to make new acquaintances, renew old friendships and present recent results of their research. Our Symposium has grown significantly in size due to a broad interest in various topics and to the quality of the presentations. For the firsttime in 40 years, the IAIS was held in the province of Ontario in Windsor, Canada's Automotive Capital and City of Roses. The 26th IAIS attracted over 100specialists from 13countries representing this interdisciplinary field in physical acoustics, image processing, applied mathematics, solid-state physics, biology and medicine, industrial applications and quality control technologies. The 26th lAIS was organized in the traditional way with only one addition-a Special Session "History of Acoustical Imaging" with the involvement of such well known scientists as Andrew Briggs, Noriyoshi Chubachi, Robert Green Jr., Joie Jones, Kenneth Erikson, and Bernhard Tittmann. Many of these speakers are well known scientists in their fields and we would like to thank them for making this session extremely successful.

Unraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques - and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains. This book starts with Brodmann's post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of "in vivo Brodmann mapping" using high-field MRI, which was introduced in the early 21st century.

Computed Tomography gives a detailed overview of various aspects of computed tomography. It discusses X-ray CT tomography from a historical point of view, the design and physical operating principles of computed tomography apparatus, the algorithms of image reconstruction and the quality assessment criteria of tomography scanners. Algorithms of image reconstruction from projections, a crucial problem in medical imaging, are considered in depth. The author gives descriptions of the reconstruction methods related to tomography scanners with a parallel X-ray beam, trough solutions with fan-shaped beam and successive modifications of spiral scanners. Computed Tomography contains a dedicated chapter for those readers who are interested in computer simulations based on studies of reconstruction algorithms. The information included in this chapter will enable readers to create a simulation environment in which virtual tomography projections can be obtained in all basic projection systems. This monograph is a valuable study on computed tomography that will be of interest to advanced students and researchers in the fields of biomedical engineering, medical electronics, computer science and medicine.

Proceedings of a workshop sponsored by the European Community and organized in Brussels, Belgium, October 1988 by the U. of Louvain Medical School, discuss problems related to the study of receptors and energy metabolism, particularly in relationship with the compartmental analysis and the modelling

Over the past two decades it has been increasingly recognized that whole-body ultrasound is an invaluable tool in the critically ill. In addition to offering rapid whole-body assessment, it has the advantage of being a bedside approach that is available at all times and can be repeated at will. Accordingly, it permits the immediate institution of appropriate therapeutic management. Whole-Body Ultrasound in the Critically Ill is the sequel to the author s previous books on the subject, which were first published in French in 1992 and 2002 and in English in 2004. This new volume reflects the latest state of knowledge by including a variety of improvements, revised definitions, and updated algorithms. Findings in respect of individual organs are clearly presented, and a particular feature is the in-depth coverage of the lungs, traditionally regarded as an area unsuitable for ultrasound. Throughout, the emphasis is on the practical therapeutic impact of the technique. Its value in a variety of settings, including unexplained shock, management of hemodynamic instability, acute respiratory failure (the BLUE protocol), and the critically ill neonate, is carefully explained. Interventional ultrasound and less widely recognized applications, such as mesenteric infarction, pneumoperitoneum, and intracranial hypertension, are also described. Pitfalls of the technique receive due attention. Today, whole-body ultrasound touches upon every area of critical care. This book, from the chief pioneer in the field, shows that the technique enables critical care physicians to detect therapeutically relevant signs easily and quickly. It will serve as an invaluable guide to the practice of a form of visual medicine."

The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

The second E. C. Workshop on Ultrasonic Tissue Characterization was organized for the assessment of research goals and plans as the basis to a grant proposal for a "Concerted Action" which will be forwarded to the European Commission. It should, therefore, not only be considered as a work in progress exhibition which succeeded the former activities within the E. C. (Inventory on Tissue Characterization in Europe and first Workshop). The Steering Group invited a 1 imited group of Institutes to send its group leader and a research fel low in the entitled field, who should expose the overall research program, as wei 1 as the more specific work on tissue characterization by RF signal analysis and spectroscopy. The ultimate goal of the Workshop has been the formulation of schemes of interaction among the Institutes and individuals and the definition of cooperative research programs. The remainder of the groups and some of the groups present are working in the field of analysis and processing of cl inical A- and B-mode echograms (i. e. video signals). Because this work is more closely related to the cl inical diagnostics it was decided that for that reason no preparatory workshop was needed. In the final proposal for the Concerted Action this work wi 1 1 get ample attention. Although not many clinicians were present, their positive interest in the sophisticated analysis techniques and their contribution to the dis cussions again have been a most valuable and stimulating experience.

Pixel detectors are a particularly important class of particle and radiation detection devices. They have an extremely broad spectrum of applications, ranging from high-energy physics to the photo cameras of everyday life. This book is a general purpose introduction into the fundamental principles of pixel detector technology and semiconductor-based hybrid pixel devices. Although these devices were developed for high-energy ionizing particles and radiation beyond visible light, they are finding new applications in many other areas. This book will therefore benefit all scientists and engineers working in any laboratory involved in developing or using particle detection.

This volume gives a survey on mathematical and computational methods in image registration. During the last year sophisticated numerical models for registration and efficient numerical methods have been proposed. Many of them are contained in this volume. The book also summarizes the state-of-the-art in mathematical and computational methods in image registration. In addition, it covers some practical applications and new directions with industrial relevance in data processing.

The present work is the second in a series constituting an extension of my doctoral thesis done at Stanford in the early 1970s. Like the earlier work, The Reciprocal Modular Brain in Economics and Politics, Shaping the Rational and Moral Basis ofOrganization, Exchange, and Choice (Plenum Publishing, 1999), it may also be considered to respond to the call for consilience by Edward O. Wilson. I agree with Wilson that there is a pressing need in the sciences today for the unification of the social with the natural sciences. I consider the present work to proceed from the perspective of behavioral ecology, specifically a subfield which I choose to call interpersonal behavioral ecology th Ecology, as a general field, has emerged in the last quarter of the 20 century as a major theme of concern as we have become increasingly aware that we must preserve the planet whose limited resources we share with all other earthly creatures. Interpersonal behavioral ecology, however, focuses not on the physical environment, but upon our social environment. It concerns our interpersonal behavioral interactions at all levels, from simple dyadic one-to-one personal interactions to our larger, even global, social, economic, and political interactions.

This book reviews and discusses the development of self-assembled nanomaterials applied in biomedical fields. Based on self-assembled nanomaterial constructions, it highlights the mechanisms of the stimuli-response-induced assembly/disassembly and transformation. Moreover, it examines healthcare-related diseases, the applications of nanomaterials and therapy/detection strategies, providing readers with both a deeper understanding of the subject and inspirations for future research. The book is primarily intended for researchers and graduate students in the fields of material sciences and chemistry who wish to learn about the principles, methods, mechanisms and biomedical applications of self-assembled nanomaterials.

Exploration of Cortical Function summarizes recent research efforts aiming at the revelation of cortical population coding and signal processing strategies. Topics include optical detection techniques of population activity in the sub-millimeter range, advanced methods for the statistical analysis of these data, and biologically inspired neuronal modeling techniques for population activities in the frameworks of optimal coding, statistical learning theory, and mean-field recurrent networks.

Exploration of Cortical Function is unique in that it covers one complete branch of population-based brain research ranging from techniques for data acquisition over data analysis up to modeling techniques for the quantification of functional principles. The volume covers an area which is of great current interest to researchers working on cerebral cortex. The combination of models and image analysis techniques to examine the activity of large cohorts of neurons is especially intriguing and prone to considerable error and debate.

The intended readership is students and researchers from many disciplines, including neuroscience, biology, physics, and computer science, interested in how an interdisciplinary framework from biology advanced statistics and computational neuroscience can be used to gather a quantitative understanding of cortical function. Experimentalists may gain insight into statistical and neuronal modeling techniques, whereas theoreticians will find an introductory treatment of neuroanatomy, neurophysiology, and measurement techniques.

A half century after its invention, and after several waves of optimism and pessimism, holography is now poised to achieve widespread application. Holograms are now being used as tools in many industries, from heads-up displays in aircraft to directing interconnections in massively parallel computing. Acoustic holograms can provide three-dimensional images of internal organs without surgery or dangerous radiation, and holography forms the basis of several other forms of nondestructive testing. This book provides both a review of the development of the field and of the applications likely to be important in the 21st century. It begins with a review by Emmett Leith, one of the inventors of holography - or re-inventors, after Denis Gabor's original work in 1947. Two chapters discuss the frontiers of holographic imaging, including color holograms and stereographic movies. Several subsequent chapters describe novel methods of forming and viewing holographic images, including the use of low-coherence sources or even computers to generate the holograms. The book concludes with a sampling of new applications of holography, including its uses in improving the efficiency of solar cells, in nondestructive testing, in improving the coherence properties of light, in data storage, and in investigations of fundamental physics.