This book provides a state-of-the-art overview of the combined use of imaging modalities to obtain important functional and morphological information on intravascular disease and enhance disease detection. It discusses the integration of intravascular ultrasound (IVUS, intravascular optical coherence tomography (OCT), intravascular photoacoustic imaging (IVPA) and acoustic radiation force optical coherence elastography (ARF-OCE), and introduces the integration of multimodality imaging systems, such as IR and florescence. It includes the latest research advances and numerous imaging photos to offer readers insights into current intravascular applications. It is a valuable resource for students, scientists and physicians wanting to gain a deeper understanding of multimodality imaging tools.

Recent advances in surgical procedures for the management of focal liver diseases have greatly increased the demand for diagnostic accuracy. So far these demands have been only partially met by further technical developments such as colour coded duplex sonography, spiral CT and marked improvements in magnetic resonance imaging. It is becoming increasingly clear that liver specific contrast media are essential for utilizing these technical developments to their fullest advantage in patient care. Against this background, a workshop was held to explore the current methods of diagnostic imaging of the liver and to try and establish a profile for the future liver specific contrast media. The pathologist's introductory and general overview is followed by chapters on the individual imaging procedures such as ultrasound, CT and MRI, so that each of the three is given the attention it deserves. The book will be of interest to radiologists from the various disciplines, and also those who plan and perform therapies, particularly surgeons and internists.

Since 1968, the International Acoustical Imaging Symposium has provided a unique forum for advanced research, promoting the sharing of technology, developments, methods and theory among all areas of acoustics. Volume 28 of the Proceedings offers an excellent collection of papers presented in six major categories, offering both a broad perspective on the state of the art in the field as well as an in-depth look at its leading edge research.

Quantitative ultrasound (QUS) of bone is a relatively recent research field. The research community is steadily growing, with interdisciplinary branches in acoustics, medical imaging, biomechanics, biomedical engineering, applied mathematics, bone biology and clinical sciences, resulting in significant achievements in new ultrasound technologies to measure bone, as well as models to elucidate the interaction and the propagation of ultrasonic wave in complex bone structures. Hundreds of articles published in specialists journals are accessible from the Web and from electronic libraries. However, no compilation and synthesis of the most recent and significant research exist. The only book on QUS of bone has been published in 1999 at a time when the propagation mechanisms of ultrasound in bone were still largely unknown and the technology was immature. The research community has now reached a critical size, special sessions are organized in major international meetings (e.g., at the World Congress of Biomechanics, the annual meetings of the Acoustical Society of America, International Bone Densitometry Workshop, etc...). Consequently, the time has come for a completely up to date, comprehensive review of the topic. The book will offer the most recent experimental results and theoretical concepts developed so far and is intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field. The central part of the book covers the physics of ultrasound propagation in bone. Our goal is to give the reader an extensive view of the mathematical and numerical models as an aid to understand the QUS potential and the types of variables that can be determined by QUS in order to characterize bone strength. The propagation of sound in bone is still subject of intensive research. Different models have been proposed (for example, the Biot theory of poroealasticity and the theory of scattering have been used to describe wave propagation in cancellous bone, whereas propagation in cortical bone falls in the scope of guided waves theories). An extensive review of the models has not been published so far. We intend in this book to present in details the models that are used to solve the direct problem and strategies that are currently developed to address the inverse problem. This will include analytical theories and numerical approaches that have grown exponentially in recent years. Most recent experimental findings and technological developments will also be comprehensively reviewed.

Based on the Lectures given during the Ispra-Course held at the Centro de Formacao Tecnica, Lisbon, Portugal, October 23-27, 1989, in collaboration with the Laboratorio Nacional de Engenharia e Tecnologia

This book covers the latest developments in tissue electrical conductivity and current density imaging, increasingly popular as well as challenging applications of MRI. These applications are enabled by the acquisition of high-quality MR phase images. This book provides a practical description of the MRI physics needed to understand and acquire phase images in MRI and the key details required to reconstruct them into conductivity, current density or electric field distributions. Comprehensive details are provided about the electrical properties of biological tissues, computational modeling considerations, experimental methods, construction of non-biological and biological phantoms and MRI pulse sequences. An inclusive review of image reconstruction algorithms, and their potential applications is provided for applications directed at determining current density or electric fields, such as in transcranial DC or AC stimulation techniques; as well as electrical conductivity reconstructions that may be of use in quantitative MRI applications used to detect cancer or other pathologies. This is an excellent book for undergraduate and graduate students beginning to explore phase, current density, and conductivity imaging in MRI, and will also be of great use to researchers interested in the area of MR-based electrical property imaging.

The Oxford Handbook of Functional Brain Imaging in Neuropsychology and Cognitive Neurosciences describes in a readily accessible manner the several functional neuroimaging methods and critically appraises their applications that today account for a large part of the contemporary cognitive neuroscience and neuropsychology literature. The complexity and the novelty of these methods often cloud appreciation of the methods' contributions and future promise. The Handbook begins with an overview of the basic concepts of functional brain imaging common to all methods, and proceeds with a description of each of them, namely magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), diffusion tensor imaging (DTI), and transcranial magnetic stimulation (TMS). Its second part covers the various research applications of functional neuroimaging on issues like the function of the default mode network; the possibility and the utility of imaging of consciousness; the search for mnemonic traces of concepts; human will and decision-making; motor cognition; language; the mechanisms of affective states and pain; the presurgical mapping of the brain; and others. As such, the volume reviews the methods and their contributions to current research and comments on the degree to which they have enhanced our understanding of the relation between neurophysiological activity and sensory, motor, and cognitive functions. Moreover, it carefully considers realistic contributions of functional neuroimaging to future endeavors in cognitive neuroscience, medicine, and neuropsychology.

This book contains thirteen contributions from invited experts of international recognition addressing important issues in shape analysis in medical image analysis, including techniques for image segmentation, registration, modelling and classification and applications in biology, as well as in cardiac, brain, spine, chest, lung and clinical practice.

This volume treats topics such as for example, anatomic and functional shape representation and matching; shape-based medical image segmentation; shape registration; statistical shape analysis; shape deformation; shape-based abnormity detection; shape tracking and longitudinal shape analysis; machine learning for shape modeling and analysis; shape-based computer-aided-diagnosis; shape-based medical navigation; benchmark and validation of shape representation, analysis and modeling algorithms.

This work will be of interest to researchers, students and manufacturers in the fields of artificial intelligence, bioengineering, biomechanics, computational mechanics, computational vision, computer sciences, human motion, mathematics, medical imaging, medicine, pattern recognition and physics.

In the past few decades, Magnetic Resonance Imaging (MRI) has become an indispensable tool in modern medicine, with MRI systems now available at every major hospital in the developed world. But for all its utility and prevalence, it is much less commonly understood and less readily explained than other common medical imaging techniques. Unlike optical, ultrasonic, X-ray (including CT), and nuclear medicine-based imaging, MRI does not rely primarily on simple transmission and/or reflection of energy, and the highest achievable resolution in MRI is orders of magnitude smaller that the smallest wavelength involved. In this book, MRI will be explained with emphasis on the magnetic fields required, their generation, their concomitant electric fields, the various interactions of all these fields with the subject being imaged, and the implications of these interactions to image quality and patient safety. Classical electromagnetics will be used to describe aspects from the fundamental phenomenon of nuclear precession through signal detection and MRI safety. Simple explanations and Illustrations combined with pertinent equations are designed to help the reader rapidly gain a fundamental understanding and an appreciation of this technology as it is used today, as well as ongoing advances that will increase its value in the future. Numerous references are included to facilitate further study with an emphasis on areas most directly related to electromagnetics.

Here is an informative book that provides theoretical perspectives on the study of fetal movement and introduces observational assessments that can be used in fetal research. It provides research tools that can be used to delineate early patterns of movement, preparing therapists for neonatal intervention and leading to a better understanding of functional activity of the fetus. Concepts in Fetal Movement Research describes various ideas in fetal development and contains original research on a variety of topics, including: the way in which events experienced in utero help neonatal interaction with parents inductive and deductive approaches to assessment development scapular movement activity/inactivity of the 12-20 week old fetus two different research tools for assessing fetal movement. future directions for research by physical therapists in collaboration with other researchersResearchers, clinicians, obstetricians, radiologists, sonographers, and neonatologists will all find this book full of helpful information. Concepts in Fetal Movement Research is an invaluable guide for both their research and their day-to-day work with patients.

The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

In modern medicine, imaging is the most effective tool for diagnostics, treatment planning and therapy. Almost all modalities have went to directly digital acquisition techniques and processing of this image data have become an important option for health care in future. This book is written by a team of internationally recognized experts from all over the world. It provides a brief but complete overview on medical image processing and analysis highlighting recent advances that have been made in academics. Color figures are used extensively to illustrate the methods and help the reader to understand the complex topics.

Towards the end of this century we celebrate three great discoveries of the last one - of X-rays in 1895, of radioactivity in 1896 and of radium in 1898 - and recall the pioneering achievements that founded the new science of radiology and changed the face of medicine forever. Dr Mould's comprehensive centennial history makes a unique contribution to the telling of this entertaining story - in the unusual and accessible style of a 'radiological photograph album'. Over 700 historical illustrations, with full and informative captions, are supported by short introductory essays to blow the dust off our fascinating radiological past in an easily readable style. The focus of this book is on the historically more interesting earlier years - of discovery and invention, diagnosis and therapy, dosimetry, risk and protection. The photographic record is complemented by archival accounts of the pioneer scientists and physicians, and of their early patients, and is interspersed with a variety of radiological anecdotes. In the several chapters on diagnostic techniques, radiotherapy and nuclear medicine the history is nevertheless brought up to date so that the old methodologies may be contrasted with newer technologies. The medical theme is itself complemented by two interesting chapters on museum and industrial applications of radiography. The predominantly photographic presentation of this book is derived from the author's earlier but smaller A History of X-rays and Radium, no longer available yet still of enduring interest. Research has been based on original source material which is fully cited and the illustrations and text are comprehensively indexed for easy retrieval of the wide variety ofpeople, techniques, apparatus and examples featured throughout this radiological journey.

Motion Correction in MR: Correction of Position, Motion, and Dynamic Changes, Volume Eight provides a comprehensive survey of the state-of-the-art in motion detection and correction in magnetic resonance imaging and magnetic resonance spectroscopy. The book describes the problem of correctly and consistently identifying and positioning the organ of interest and tracking it throughout the scan. The basic principles of how image artefacts arise because of position changes during scanning are described, along with retrospective and prospective techniques for eliminating these artefacts, including classical approaches and methods using machine learning. Internal navigator-based approaches as well as external systems for estimating motion are also presented, along with practical applications in each organ system and each MR modality covered. This book provides a technical basis for physicists and engineers to develop motion correction methods, giving guidance to technologists and radiologists for incorporating these methods in patient examinations.

This volume addresses up-to-date light microscopy approaches and toolsets offered for live- or fixed-cell observations. The imaging strategies discussed in this book include confocal laser scanning and spinning disk confocal microscopy, FRET, FRAP, and laser microsurgery experiments. Chapters also describe the use of these imaging methodologies to study properties of a multitude of biomolecular targets in a broad range of model systems ranging from bacteria over tissue to whole animal imaging. Light Microscopy: Methods and Protocols puts special focus on system instrumentation parameters and sophisticated labeling and detection methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Light Microscopy: Methods and Protocols offers the novice user with straightforward strategies to address biological questions, while providing the experienced researcher with the latest applications that can be useful in routine practices. This book also serves as a useful teaching manual in practical courses on light microscopy.

Effective stroke therapy can be improved through real-time monitoring of the neurological and cardiovascular responses to treatment. This requires crucial knowledge on behalf of both the sonographer and stroke physician to make the best decisions for the patient so as to minimize the damage caused by the original stroke and the risk of further stroke.

"Cerebrovascular Ultrasound in Stroke Prevention and Treatment, Second Edition, " takes a practical approach to the examination of patients, the interpretation of ultrasound studies and the application of cerebrovascular ultrasound in the development of management and treatment studies, assisting neurologists, radiologists, and ultrasonographers in stroke therapy.

Introduces both optical microscopy and medical imaging with an emphasis on recurring themes such as resolution and contrast to reinforce understanding. Includes many illustrations and boxed material that give more detailed explanations. Features hands-on activities and experiments. Provides end-of-chapter problems for self-study. Offers supplementary online materials including a solutions manual.

Immunoassay procedures (isotopic and non-isotopic) have become one of the single most important techniques in present-day diagnostic medicine. This book is designed as an introductory test for the staff of clinical research laboratories who conduct or intend to conduct such techniques, and will be of great value to the clinicians who make use of such services. The volume takes a three-pronged approach in it's in-depth presentation: explanation of the basic principles and applications of radioimmunoassays and non-isotopic immunoassays; practical illustrations of the various steps involved in immunoassays; discussion of the problems and pitfalls in immunoassays and how to avoid them. This fifth revised edition is a worthy successor to it's predecessors in this famous "Laboratory Techniques" series.

Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models describes the latest imaging and imag analysis techniques that have been developed at leading centers for the visualization, analysis, and understanding of normal and abnormal cardiac motion with magnetic resonance imaging (MRI). The use of MRI in measuring cardiac motion is particularly important because MRI is non-invasive, and it is the only modality capable of imaging detailed intramural motion within the myocardium. Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. In particular, it is more tutorial in nature than most of the technical papers where the research was originally published. Practitioners and researchers working in the field of cardiovascular MRI will find the book to be filled with practical technical details and references to other work, enabling the implementation of existing methods and serving as a basis for further research in the area.

Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians. Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound.

The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.

There have been many great advances in the field of biomedical imaging in recent years, with supramolecular chemistry playing a key role in the evolution of modern imaging techniques. Non-covalent supramolecular interactions are fundamental to countless biological processes, from host-guest binding to the stabilisation of complex structures. Supramolecular chemistry techniques can be employed to create probes that can be targeted to either exploit or disrupt these interactions, giving the potential for both diagnostic and therapeutic effects. Furthermore, in techniques such as contrast enhanced MRI, controlling the interactions between solvent molecules and the imaging agent is crucial to the development of the technique. With rapid growth in the synthesis and study of molecular imaging agents, the understanding of their associated techniques has sometimes lagged behind. Supramolecular Chemistry in Biomedical Imaging will fill this gap by clarifying the state of current understanding and the nature of the underlying problems inherent to addressing problems in biology. It will cover both the techniques used in imaging and the molecular and supramolecular systems used to exploit them. This publication targets academics coming to the field from mainstream supramolecular chemistry, research graduates and undergraduates interested in supramolecular chemistry, synthesis or imaging agents and imaging techniques for biomedical applications.

This book presents the latest findings in mechanosensitivity of the nervous system. The nervous system stands out from a number of tissues because besides reacting to the mechanical stress it is transmitting its own response to other organs and tissues, which are located downstream of its signaling pathway. For this reason any type of mechanical stimulation of the nervous system, which is capable of triggering a physiological response, has high scientific and practical significance, since it allows its use beyond a particular experimental model anywhere where it is contributing to a particular pathological condition.

This book is a unique collection of reviews outlining the current knowledge and the future developments in this rapidly growing field. Currently, investigations of the effects of mechanical stress on the nervous system are focused on several issues. The majority of studies investigate the effects of mechanical stimulation on mechanosensitive channels, as its primary target and interactive agent, and aim on description of downstream intracellular signaling pathways together with addressing general issues of biomechanics of the nervous system. Knowledge of biomechanics, and mechanisms, which underlie it on organism, organ, tissue and cellular level, is necessary for understanding of the normal functioning of living organisms and allows to predict changes which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention.

The book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.