This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.

Orbit and Neuro-ophthalmic Imaging is explored in this important Neuroimaging Clinics issue. Articles include: Imaging indication, protocols, anatomy, and pitfalls; Orbital ultrasonography and optical coherence tomography- what radiologists need to know; Advanced imaging techniques for the retina and visual pathway; Imaging of optic neuropathy and chiasmatic disorder; Imaging of post-chiasmatic disorder and higher cortical visual dysfunction; Imaging of diseases of the ocular motor pathway; Imaging of orbital trauma and emergent non-traumatic conditions; Imaging of ocular prosthesis and orbital reconstruction flaps; Imaging of pediatric ophthalmologic conditions; and more!

Guest editors Claire Tempany and Tina Kapur review MR-Guided Interventions in this important issue in MRI Clinics of North America. Articles include: MR sequences and rapid acquisition for MR-guided interventions; MR-guided breast interventions: role in biopsy targeting and lumpectomies; MR-guided passive catheter tracking for endovascular therapy; MRgFUS update on clinical applications; MR-guided spine Interventions; MR-guided prostate biopsy; Interventional MRI Clinic: the Emory experience; MR-guided cardiac interventions; MR-guided functional neurosurgery; MR-guided active catheter tracking; MR-guided drug delivery; MR-guided thermal therapy for localized and recurrent prostate cancer; MR neurography for guiding nerve blocks and its role in pain management; MR-guided gynecologic brachytherapy; and more!

Dr. Robert Gore (co-editor of Textbook of Gastrointestinal Radiology) has assembled an expert panel of authors on the topic of The Acute Abdomen. Articles will include: Evaluating the patient with right upper quadrant pain; Evaluating the patient with left upper quadrant pain; Evaluating the patient with right lower quadrant pain; Evaluating the patient with left lower quadrant pain; Acute pancreatitis; Acute disorders of the abdominal aorta; Bowel obstruction; Bowel ischemia; Acute infectious and inflammatory enterocolitides; Acute urinary tract disorders; Acute gynecologic disorders; Evaluating the acute abdomen in the pregnant patient; MR evaluation of the acute, non-traumatic abdomen in adolescents and adults; and more!

The 7 chapters in this book have been selected from the contents of the Oncological Imaging section in Grainger & Allison's Diagnostic Radiology 6e. These chapters provide a succinct up-to-date overview of current imaging techniques and their clinical applications in daily practice and it is hoped that with this concise format the user will quickly grasp the fundamentals they need to know. Throughout these chapters, the relative merits of different imaging investigations are described, variations are discussed and recent imaging advances are detailed. Please note that the following chapters represent a portion of the oncological imaging aspects in the comprehensive 6th edition of Grainger's & Allison's Diagnostic Radiology (for example, abdominal tumours are considered in section C "Abdominal Imaging")

This issue, edited by Dr. Rakesh Kumar, reviews current clinical information in "PET Based Interventions." Articles will include: PET/CT in Radiofrequency Ablation; PET/CT Guided FNAC/Biopsy; PET/CT in Radiotherapy Planning; Dual Time Point Imaging; The Role of PET in Radiation Oncology; PET/CT in Individualization of Treatment (Personalized medicine); Ga68-DOTA-TOC PET/CT in targeted radionuclide therapy (Lu188 therapy for NET); Role of FDG PET/CT in Targeted Radionuclide Therapy of Endocrine Malignancies; Overview of Conventional Imaging Based Intervention in Clinical Practice; Special Techniques in PET/CT in Evaluating Genito-urinary Malignancies; and more!

Drs. Robert J. Lewandowski and Matthew S. Davenport have assembled an expert panel of authors on the topic of Interventional Radiology. Articles will include: Abdominal Biopsy: Technical and Clinical Considerations; Intra-arterial Therapies for Liver Masses; Liver Ablation: Best Practice; Renal Intervention; Imaging (Findings) after Intervention; Assessing Imaging Response to Therapy; Liver Masses: Imaging Evaluation in Non-cirrhotics; Imaging in Cirrhotics: Current Evidence; Renal Masses: Imaging Evaluation; Adrenal Imaging/Intervention; The Pancreas; and more!

This issue of Clinics in Chest Medicine focuses on Chest Imaging. Drs. Lynch and Chung have assembled an expert panel of authors on the topics of:Approach to chest CT, CT screening for lung cancer,The solitary pulmonary nodule, Staging of lung cancer, Imaging of infections, ICU imaging, Pulmonary vascular diseases, Occupational and environmental lung disease, Idiopathic interstitial pneumonias, Connective tissue disease-related thoracic disease and more!

Colonoscopy is the bread and butter for endoscopists and advances in the procedure to reduce time, improve efficiency, and prevent errors are very important for this group. The newest advances look at colonoscopy efficiency and a better way to target tissue sampling, which avoids random biopsies and instead looks at ways to predict areas for sampling. The Guest Editors have selected top experts to provide these important updates and they also address current thinking that questions the continued value of colonoscopies as predictors of colon cancer. The issue will be a very popular one, and it needs to be heavily promoted.

Meticulously updated by board-certified oral and maxillofacial radiologist, Dr. Dania Tamimi and her team of sub-specialty experts, Specialty Imaging: Temporomandibular Joint and Sleep-Disordered Breathing, second edition, is a comprehensive reference ideal for anyone involved with TMJ imaging or SDB, including oral and maxillofacial radiologists and surgeons, TMJ/craniofacial pain specialists, sleep medicine specialists, head and neck radiologists, and otolaryngologists. This detailed, beautifully illustrated volume covers recent advances in the diagnosis and treatment of both the TMJ and SDB, including how related structures are affected. Employing a multifaceted, multispecialty approach, the clinical perspectives and imaging expertise of today's research specialists are brought together in a single, image-rich, easy-to-read text. Reflects the current emphasis on holistic diagnosis and treatment not just of the TMJ but of all related structures that can be adversely affected by any TMJ dysfunction  Examines a variety of presenting clinical signs or symptoms, discusses imaging strategies and  the associated conditions revealed by imaging, and helps you develop differential diagnoses  Provides current, detailed information on the relationship between TMJ disorders and SDB, how imaging shows the correlation between the two, and risk factors for SDB  Includes upper respiratory tract diagnoses, with multiple subsections on the nasal cavity, paranasal sinuses, nasopharynx, oropharynx, and hypopharynx, each with multiple new chapters  Features new chapters on ultrasonography of the TMJ and upper respiratory tract, new content on 3D and 4D modeling and surface rendering, a new section on imaging of upper respiratory tract procedures, and new content detailing the tie-in between occlusion and SDB  Includes an expanded Modalities section that includes new chapters on formulating a TMJ/upper respiratory tract report; plain film imaging of the TMJ and upper respiratory tract; CBCT analysis of the upper respiratory tract; dynamic MR of the TMJ and upper respiratory tract, and ultrasound of the TMJ   Covers the role that TMJ plays in facial growth and development, stomatognathic system function, and how TMJ abnormalities change the dimensions of the facial skeleton and surrounding structures  Contains over 5,000 print and online-only images (more than 300 are new), including radiologic images, full-color medical illustrations, and histologic and gross pathology photographs  Reflects updates to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC-TMD)-the major clinical classification method and a key tool to assess/diagnose TMJ issues and facilitate communication for consultants, referrals, and prognoses  Includes an eBook version?that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud 

This two-part issue, edited by Dr. Rathan Subramaniam, reviews current clinical information in "PET/CT and Patient Outcomes." In Part I of this issue, articles will include: Head and Neck Cancer, Lung Cancer, Esophageal Cancer, Breast Cancer, Lymphoma, Melanoma, Prostate Cancer, Multiple Myeloma, Thyroid Cancer, Radiation Therapy Planning, Infection/Inflammation, Colorectal Cancer, and more!

This issue of Cardiac Electrophysiology Clinics examines Frontiers in Non-invasive Cardiac Mapping. Topics include imaging of heart rhythm disorders, experimental validation and modeling of validation, challenges and future directions of inverse problems, phase mapping of cardiac fibrillation, frequency domain analysis, analysis of diagnostic 12-lead electrocardiography and 3D non-invasive mapping, and many more.

This issue of Interventional Cardiology Clinics, edited by Matthew J. Price, is devoted to Intravascular Imaging. Dr. Price assembled a group of expert contributors to review the following topics: IVUS for the assessment of coronary lesion severity and optimization of PCI; IVUS for the diagnosis and treatment of left main coronary artery disease; Fundamentals of OCT: image acquisition and interpretation; Technique and Best Practices for Intracoronary OCT; Assessment and quantitation of stent results by intracoronary OCT; PCI planning and optimization with intracoronary OCT; Advances in Automated Assessment of Intracoronary OCT and Their Clinical Application; Diagnosis and evaluation of stent thrombosis using OCT; Acute and long-term evaluation of bioresorbable scaffolds by OCT; Role of OCT in the diagnosis, evaluation, and management of spontaneous coronary artery dissection; and Neointimal Coverage after Drug-Eluting Stent Implantation: Insights from Optical Coherence Tomography.

This two-part issue, edited by Dr. Rathan Subramaniam, reviews current clinical information in "PET/CT and Patient Outcomes." In Part II of this issue, articles will include: Hepatobiliary and Pancreatic Cancer; Endometrial, Cervical & Ovarian Cancer; Renal, Bladder and Testicular Cancer; Musculoskeletal and Soft Tissue Tumors; Myocardial Perfusion / Viability; Unknown Primary Cancer; Gastric Cancer; Brain Tumors; Neuroendocrine Tumors, and more!

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.

Editor Deborah Shatzkes and authors review important areas in Craniofacial Trauma. Articles will include: Optimizing craniofacial CT technique, Orbital and facial fractures, Orbital and facial soft tissue injuries, Skull base fractures and their complications, Temporal bone trauma, Pediatric considerations in craniofacial trauma, Cerebrovascular trauma, Surgical perspectives in craniofacial trauma, and more!

Chest MRI is explored in this important issue in MRI Clinics of North America. Articles include: MRI of Mediastinal Masses; State of the art: MR Imaging of the Thymus; Novel MR Applications for Pleural Evaluation; MRI Imaging of Chest Wall Tumors; MR Imaging of the Lungs with Hyperpolarized Gases: Technique and Applications; Lung Cancer Assessment with MR Imaging: An Update; PET/MRI in Chest Diseases; Imaging Pulmonary Arterial Thromboembolism: Challenges and Opportunities; MR Imaging of the Thoracic Aorta; MR Imaging of Thoracic Veins; State of the Art MR Imaging in Vascular Thoracic Outlet Syndrome; Pediatric Chest MR Applications, and more!

Although the capabilities of computer image analysis do not yet match those of the human visual system, recent developments have made great progress towards tackling the challenges posed by the perceptual analysis of images.

This unique text/reference highlights a selection of important, practical applications of advanced image analysis methods for medical images. The book covers the complete methodology for processing, analysing and interpreting diagnostic results of sample computed tomography (CT) images. The text also presents significant problems related to new approaches and paradigms in image understanding and semantic image analysis. To further engage the reader, example source code is provided for the implemented algorithms in the described solutions.

Topics and features: describes the most important methods and algorithms used for image analysis, including holistic and syntactic methods; examines the fundamentals of cognitive computer image analysis for computer-aided diagnosis and semantic image description, introducing the cognitive resonance model; presents original approaches for the semantic analysis of CT perfusion and CT angiography images of the brain and carotid artery; discusses techniques for creating 3D visualisations of large datasets, and efficient and reliable algorithms for 3D rendering; reviews natural user interfaces in medical imaging systems, covering innovative Gesture Description Language technology; concludes with a summary of significant developments in advanced image recognition techniques and their practical applications, along with possible directions for future research.

This cutting-edge work is an invaluable practical resource for researchers and professionals interested in medical informatics, computer-aided diagnosis, computer graphics, and intelligent information systems.

This book discusses a novel and high-rate-capable micro pattern gaseous detector of the Micromegas (MICRO-MEsh GAS detector) type. It provides a detailed characterization of the performance of Micromegas detectors on the basis of measurements and simulations, along with an in-depth examination of analysis and reconstruction methods. The accurate and efficient detection of minimum ionizing particles in high-rate background environments is demonstrated. The excellent performance determined here for these lightweight detectors will make possible the live medical imaging of a patient during ion-beam treatment.

Dr. Michael Pinsky has assembled an expert team of authors on the topic of Hemodynamic Monitoring. Articles topics include: The interface between monitoring and physiology at the bedside; Defining goals of resuscitation in the critically ill; Minimally invasive hemodynamic monitoring; Bedside ultrasound for the intensivist; Invasive hemodynamic monitoring; Functional hemodynamic monitoring; Using what you get: dynamic physiological signatures of critical illness; and Effect of organizational issues on resuscitation effectiveness.

This textbook summarizes the basic knowledge of atomic, nuclear, and radiation physics that professionals working in medical physics and biomedical engineering need for efficient and safe use of ionizing radiation in medicine. Concentrating on the underlying principles of radiation physics, the textbook covers the prerequisite knowledge for medical physics courses on the graduate and post-graduate levels in radiotherapy physics, radiation dosimetry, imaging physics, and health physics, thus providing the link between elementary undergraduate physics and the intricacies of four medical physics specialties: diagnostic radiology physics, nuclear medicine physics, radiation oncology physics, and health physics. To recognize the importance of radiation dosimetry to medical physics three new chapters have been added to the 14 chapters of the previous edition. Chapter 15 provides a general introduction to radiation dosimetry. Chapter 16 deals with absolute radiation dosimetry systems that establish absorbed dose or some other dose related quantity directly from the signal measured by the dosimeter. Three absolute dosimetry techniques are known and described in detail: (i) calorimetric; (ii) chemical (Fricke), and (iii) ionometric. Chapter 17 deals with relative radiation dosimetry systems that rely on a previous dosimeter calibration in a known radiation field. Many relative radiation dosimetry systems have been developed to date and four most important categories used routinely in medicine and radiation protection are described in this chapter: (i) Ionometric dosimetry; (ii) Luminescence dosimetry; (iii) Semiconductor dosimetry; and (iv) Film dosimetry. The book is intended as a textbook for a radiation physics course in academic medical physics graduate programs as well as a reference book for candidates preparing for certification examinations in medical physics sub-specialties. It may also be of interest to many professionals, not only physicists, who in their daily occupations deal with various aspects of medical physics or radiation physics and have a need or desire to improve their understanding of radiation physics.

This issue, edited by Dr. Kirkland Davis, will comprehensively review imaging of the knee. Articles will include: Magnetic Resonance Imaging of the Meniscus; MRI of Cruciate Ligaments; Magnetic Resonance Imaging of the Extensor Mechanism; Quantitative Magnetic Resonance Imaging of the Articular Cartilage of the Knee Joint; Magnetic Resonance Imaging of the Pediatric Knee; MRI of Extra-Synovial Inflammation and Impingement about the Knee; A Biomechanical Approach to Interpreting MRI of Knee Injuries; MRI Assessment of Arthritis of the Knee; MRI of the Post-Operative Meniscus; MR Imaging of Cartilage Repair Procedures; Imaging the Knee in the Setting of Metal Hardware, and more!

This book provides an overview on the critical role of diagnostic imaging in the assessment of patients with suspected alimentary tract perforation, an emergent condition that requires prompt surgery. With the aid of numerous high-quality images, it is described how different imaging modalities, including plain film X-ray, ultrasonography and multidetector row computed tomography (MDCT), permit correct diagnosis of the presence and cause of the perforation and of associated pathologies. Particular attention is paid to MDCT, with full description of its role in a range of scenarios at various levels of the alimentary tract. Imaging of GI tract perforation in different patient groups, such as pediatric patients, the elderly and oncologic patients, is also addressed. This volume will greatly assist residents in radiology, radiologists and physicians who are daily involved in the management of patients with clinically suspected alimentary tract perforation.

State of the Art CT and MR Imaging of Coronary Artery Disease and the Myocardial Ischemic Cascade is covered extensively in this issue of Radiologic Clinics. Articles will include: Imaging Coronary Artery Disease and the Myocardial Ischemic Cascade; CT Imaging of Coronary Artery Plaque; Coronary CT Angiography in Clinical Practice; Beyond Stenosis Detection: CT Approaches for Determining the Functional Relevance of Coronary Artery Disease; CT Assessment of Coronary Artery Disease; Cardiac CT for the Evaluation of the Acute Chest Pain Syndrome; Current State of the Art Cardiovascular MRI Techniques for Assessment of Ischemic Heart Disease; Global and Regional Functional Assessment of Ischemic Heart Disease with Cardiac MRI; MRI of the Coronary Vasculature: Imaging the Lumen, Wall and Beyond; Delayed Enhanced Viability Imaging: Techniques and Clinical Applications; Tissue Characterization of the Left Ventricular Myocardium: State of the Art Techniques and Emerging Clinical Utility; Stress Cardiac MRI: the Role of Stress Functional Assessment and Perfusion Imaging in the Evaluation of Ischemic Heart Disease, and much more!

Abdominal Ultrasound is comprehensively reviewed by guest editor Wui K. Chong and authors. Articles will include: Ultrasound of the Liver and Spleen; Ultrasound of the Gallbladder and Biliary Tree; Doppler US of the Liver, Portal Hypertension, and TIPS; Contrast evaluation of liver masses; Elastography of the Abdomen; The Role of Sonography in Liver Transplantation; Renal Ultrasound; Ultrasound of the Renal Transplant; Sonography of the Retroperitoneum; Ultrasound Assessment of the Aorta and Mesenteric Arteries; Sonography of the Bowel; Ultrasound of the Abdominal Wall; Ultrasound-Guided Intervention in the Abdomen and Pelvis, and more!