This volume examines the role of steroids and peptides in the
regulation of pregnancy and pregnancy outcome, and their long-term
effects including possible influences on adult-onset diseases.
During pregnancy the placenta acts as a central regulator and
coordinator of maternal and fetal physiology, and the onset of
labor, through its production and regulation of steroids and
peptides. Perturbations to this regulatory system can result in
poor pregnancy outcome, such as preterm birth and low birth weight.
These in turn are linked to diseases in later life. Intriguingly,
many of these regulatory actions of steroids and peptides also
occur in the brain. The induction and suppression of peptides by
steroids appears to be key to regulatory function in both brain and
placenta. These interweaving strands, linking basic science with
obstetrics, are all reviewed in depth here producing a fascinating
account of an important area of materno-fetal medicine.
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