Ant sting allergy in Australia is predominantly due to the Myrmecia
pilosula species complex (Jack Jumper Ant, JJA) and venom
immunotherapy has been shown to be effective in preventing
anaphylaxis to the sting of this ant. This work describes the
development of a number of analytical techniques to separate and
characterise JJA venom components. These techniques were then used
to determine the allergenicity of previously described venom
peptides in their native forms, identify additional allergens and
to update nomenclature used to describe the allergens. They were
subsequently applied to the standardisation of venom prior to new
batches being used for the diagnosis and treatment of JJA sting
allergy. Myr p 2 was found to be the only major allergen in JJA
venom, whilst Myr p 1 and Myr p 3 were minor allergens. There were
an additional five IgE-binding proteins that require further
characterisation before they can be named as allergens. A
standardisation procedure was validated that is able to control the
quality of venom so that it complies with the requirements
described in the European Pharmacopoeia.
General
Imprint: |
VDM Verlag Dr. Mueller E.K.
|
Country of origin: |
Germany |
Release date: |
August 2008 |
First published: |
August 2008 |
Authors: |
Michael Wiese
|
Dimensions: |
229 x 152 x 10mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
192 |
ISBN-13: |
978-3-639-05169-8 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-639-05169-6 |
Barcode: |
9783639051698 |
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