The study was designed for phytochemical investigations of
ethanolic extract of bark and leaf of Swietenia mahagoni belonging
to the family of Meliaceae and evaluation of their biological
activities with the special emphasis on analgesic,
anti-inflammatory, anti-microbial and cytotoxic screening in
different animal model. Phytochemical investigations were done by
extensive analysis with high resolution proton NMR spectroscopic
data. The ethanol extract of stem bark was partitioned between
pet-ether, dichloromethane and methanol fractions. Chromatographic
isolation of dichloromethane fraction using column chromatography
followed by preparative TLC afforded tetranortriterpenoid compound.
Ethanol extract and different fractions showed significant
analgesic and anti-inflammatory potential.From the bio-assay of
different fractions and extract, significant cytotoxic properties
were evaluated whereas mild to moderate antimicrobial activity was
found in this study.
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