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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Deriving Drug Discovery Value from Large-Scale Genetic Bioresources - Proceedings of a Workshop (Paperback)
Loot Price: R986
Discovery Miles 9 860
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Deriving Drug Discovery Value from Large-Scale Genetic Bioresources - Proceedings of a Workshop (Paperback)
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The process of discovering and developing a new drug or therapy is
extremely costly and time consuming, and recently, it has been
estimated that the creation of a new medicine costs on average more
than $2 billion and takes 10 years to reach patients. The
challenges associated with bringing new medicines to market have
led many pharmaceutical companies to seek out innovative methods
for streamlining their drug discovery research. One way to increase
the odds of success for compounds in the drug development pipeline
is to adopt genetically guided strategies for drug discovery, and
recognizing the potential benefits of collecting genetic and
phenotypic information across specific populations, pharmaceutical
companies have started collaborating with healthcare systems and
private companies that have curated genetic bioresources, or large
databases of genomic information. Large-scale cohort studies offer
an effective way to collect and store information that can be used
to assess gene?environment interactions, identify new potential
drug targets, understand the role of certain genetic variants in
the drug response, and further elucidate the underlying mechanisms
of disease onset and progression. To examine how genetic
bioresources could be used to improve drug discovery and target
validation, the National Academies of Sciences, Engineering, and
Medicine hosted a workshop in March 2016. Participants at the
workshop explored the current landscape of genomics-enabled drug
discovery activities in industry, academia, and government;
examined enabling partnerships and business models; and considered
gaps and best practices for collecting population data for the
purpose of improving the drug discovery process. This publication
summarizes the presentations and discussions from the workshop.
Table of Contents Front Matter 1 Introduction and Themes of the
Workshop 2 Maximizing Discovery Capabilities Through Cohort Design
3 Discovery Activities Related to Genetic Bioresources 4 Business
Models That Support Bioresource Discovery and Collaboration 5
Potential Next Steps in Using Genomics to Advance Drug Discovery
References Appendix A: Workshop Agenda Appendix B: Speaker
Biographical Sketches Appendix C: Statement of Task Appendix D:
Registered Attendees
General
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