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Drug Research and Development for Adults Across the Older Age Span - Proceedings of a Workshop (Paperback)
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Drug Research and Development for Adults Across the Older Age Span - Proceedings of a Workshop (Paperback)
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There is a void in evidence-based information for making informed
decisions on how to optimize care for older adults, particularly
those 80 years and over. Because older adults are vastly
underrepresented in clinical trials, there is a dearth of
information about the appropriate use of drugs in this population.
Yet older adults have higher rates of comorbidities and
simultaneous use of multiple medications than the general
population, and are the majority users of many medications.
Additionally, age-related physiological and pathological changes,
particularly for adults 80 years of age and older, can lead to
significant differences in the pharmacokinetics (PK)2 and
pharmacodynamics (PD)3 of a given drug compared to the general
population. On August 5 and 6, 2020, the National Academies of
Sciences, Engineering, and Medicine hosted a workshop titled Drug
Research and Development for Adults Across the Older Age Span. The
workshop was designed to examine the challenges and opportunities
in drug research and development for older adult populations,
explore barriers that impede safety and efficacy studies in these
populations, and share lessons learned for better understanding
clinical pharmacology for populations over age 65. This publication
summarizes the presentation and discussion of the workshop. Table
of Contents Front Matter 1 Introduction 2 Inclusion of Older Adults
in Clinical Trials: An Evolving Landscape 3 Overcoming Key Barriers
4 Alternative Study Approaches 5 Strategies for Engaging Older
Adults in Clinical Research 6 Clinical Trials in the Era of
COVID-19 and Beyond 7 Reflections and Key Takeaways Appendix A:
References Appendix B: Workshop Agenda Appendix C: Speaker
Biosketches
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