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The Arctic Aeromedical Laboratory's Thyroid Function Study - A Radiological Risk and Ethical Analysis (Paperback)
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The Arctic Aeromedical Laboratory's Thyroid Function Study - A Radiological Risk and Ethical Analysis (Paperback)
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During the 1950s, with the Cold War looming, military planners
sought to know more about how to keep fighting forces fit and
capable in the harsh Alaskan environment. In 1956 and 1957, the
U.S. Air Force's former Arctic Aeromedical Laboratory conducted a
study of the role of the thyroid in human acclimatization to cold.
To measure thyroid function under various conditions, the
researchers administered a radioactive medical trace, Iodine-131,
to Alaska Natives and white military personnel; based on the study
results, the researchers determined that the thyroid did not play a
significant role in human acclimatization to cold. When this study
of thyroid function was revisited at a 1993 conference on the Cold
War legacy in the Arctic, serious questions were raised about the
appropriateness of the activity?whether it posed risks to the
people involved and whether the research had been conducted within
the bounds of accepted guidelines for research using human
participants. In particular, there was concern over the relatively
large proportion of Alaska Natives used as subjects and whether
they understood the nature of the study. This book evaluates the
research in detail, looking at both the possible health effects of
Iodine-131 administration in humans and the ethics of human
subjects research. This book presents conclusions and
recommendations and is a significant addition to the nation's
current reevaluation of human radiation experiments conducted
during the Cold War. Table of Contents Front Matter Executive
Summary 1 Introduction 2 Health Effect of I131 Administration in
Humans 3 The Ethics of Human Subjects Research 4 Conclusions and
Recommendations 5 References A. Thyroid Function in Health and
Disease B. Summary of the Public Session C. Thyroid Radaition Dose
Estimates for I131 D. Secretary of Defense Letter E. Informed
Consent Elements of Disclosure F. Principles for the Conduct of
Research in the Arctic G. Biographical Sketches of Committee
Members H. Glossary
General
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