Amorphous Solid Dispersions - Theory and Practice (Hardcover, 2014 ed.)

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol (R), and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Delivery Science and Technology
Release date:	November 2014
First published:	2014
Editors:	Navnit Shah • Harpreet Sandhu • Duk Soon Choi • Hitesh Chokshi • A. Waseem Malick
Dimensions:	235 x 155 x 40mm (L x W x T)
Format:	Hardcover
Pages:	699
Edition:	2014 ed.
ISBN-13:	978-1-4939-1597-2
Categories:	Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	1-4939-1597-5
Barcode:	9781493915972

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