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Estrogen Effects in Psychiatric Disorders (Paperback, 2005 ed.)
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Estrogen Effects in Psychiatric Disorders (Paperback, 2005 ed.)
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A number of studies, mostly focusing on estrogen replacement
therapy in women, have reported beneficial actions of these
hormones on various neurobiological and neuropathological
parameters in health and disease. Recent research has focused on
gender differences and there is increasing evidence that estrogens
exert protective effects in schizophrenia. Hormonal fluctuations or
lack of estrogen may increase the risk of depression among
vulnerable women. Treatment of depression with estrogen may
stabilize and restore disrupted homeostasis - as during
post-partum, premenstrual, or perimenopausal conditions - and act
as a psychomodulator to offset vulnerability to dysphoric mood when
estrogen levels are significantly decreased, as in the case of
postmenopausal women. Studies on the effect of estrogens on
Alzheimer's Disease are still rather controversial, they do,
however, facilitate the hypothesis that estrogens may have a
modifying effect on the onset and course of AD, at least in
subgroups of patients.
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