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Cancer - Diagnosis & Future Chemoprotective Agents (Paperback)
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Cancer - Diagnosis & Future Chemoprotective Agents (Paperback)
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Cancer is a disease characterized by reduction or loss of
effectiveness in normal cellular control mechanism which regulates
multiplication. A normal cell turns into a cancer cell because of
one or more mutations in its DNA, which can be acquired or
inherited. In the body, every cell type has its own unmatched
signature, referred to as biomarkers, they are useful in the
diagnosis, monitoring and in predicting the disease progression. It
is found that the mediators of inflammation are important
constituents of the local environment of tumors. In some types of
cancer, inflammatory conditions are present before a malignant
change develops. Conversely, in other types of cancer, an oncogenic
change induces an inflammatory microenvironment which promotes the
tumor development. In some cases, use of NSAIDs is associated with
lower risks for esophageal, gastric and colon cancers as well as
other solid tumors. Chronic intake of NSAIDs may reduce
carcinogenesis by inhibiting production of PGs, cytokines and
angiogenic factors. Moreover, the ability of these NSAIDs drugs to
prevent cancer is thought to be due, in part, to COX inhibition.
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