This book deals with the concept of isosterism, bioisosterism and
retroisosterism. Specifically it gives the bioisosteric correlation
of tetrazole moiety with carboxylic group with the help of
different parameters and theories. Carboxylic group is chiefly
presents in proteins and peptides, thus emphasis is laid on the
fact that how this carboxylic acid has been replaced by the
tetrazoles in development of new chemical entities which are under
clinical trials and others which are prevailing as drugs in market.
Effective results in pharmacokinetic and pharmacodynamic properties
of compounds have been observed. This book also highlights the
effect of tetrazoles in place of carboxylic groups, studied
specifically as templates in growth hormone, as in anti-HIV agents
and as modifier of enzyme activity. Lastly it gives the idea of
retroisosterism which is based on the inversion of a determined
functional group present in the lead compound structure.
Furthermore, the role of bioisosters in drug development and drug
discovery is briefly discussed along with the future prospects.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
July 2012 |
First published: |
July 2012 |
Authors: |
Nitin Kumar
|
Dimensions: |
229 x 152 x 4mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
60 |
ISBN-13: |
978-3-659-19935-6 |
Categories: |
Books >
Medicine >
Other branches of medicine >
Pharmacology >
General
|
LSN: |
3-659-19935-4 |
Barcode: |
9783659199356 |
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