The Hypertrophied Heart (Paperback, Softcover reprint of the original 1st ed. 2000)

Whenever the heart is challenged with an increased work load for a prolonged period, it responds by increasing its muscle mass--a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situa tions such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss), and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy. Various hormones such as catecholamines, thyroid hormones, angiotensin II, endothelin, and growth factors have also been shown to induce cardiac hypertrophy. Although the exact mechanisms underlying or pathological forrns of cardiac hypertrophy are poorly under the physiological stood, an increase in the intraventricular pressure is believed to represent the major stimulus for the development of cardiac hypertrophy. In this regard, stretching of the cardiac muscle has been shown to induce the hypertrophic response, but the role of metabolic influences in this process cannot be ruled out. Furthermore, different hormones and other interventions in the absence of stretch have been observed to stimulate protein synthesis in both isolated cardiomyocyte and vascular myocyte preparations. Nonetheless, it is becoming dear that receptor as well as phospholipid linked signal transduction pathways are activated in some specific manner depend ing upon the initial hypertrophic stimulus, and these then result in an increase in the size and mass of cardiomyocytes.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Progress in Experimental Cardiology, 3
Release date:	March 2013
First published:	2000
Editors:	Nobuakira Takeda • Makoto Nagano • Naranjan S. Dhalla
Dimensions:	235 x 155 x 24mm (L x W x T)
Format:	Paperback
Pages:	469
Edition:	Softcover reprint of the original 1st ed. 2000
ISBN-13:	978-1-4613-6991-2
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
LSN:	1-4613-6991-6
Barcode:	9781461369912

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