Heart failure is the main cause of death and disability in the
industrialized world. There is a major need for novel therapeutics
for prevention and reversal of cardiac pathology associated with
heart failure and cardiac enlargement. Over recent years, dramatic
progress has been made in unravelling the cellular circuitry
involved in cardiac failure, as well as in normal cardiac growth,
development and apoptosis. This work has revealed new and
unexpected therapeutic targets in the heart. In addition, advances
in understanding the role of stem cells in cardiac physiology have
suggested strategies for cardiac repair and regeneration once
thought impossible.
This book describes the work of leading investigators studying
the basic mechanisms of cardiac growth, function and dysfunction.
There are also exciting contributions from researchers developing
novel therapeutic strategies for cardiac disease. The unique
feature is the discussions amongst the contributors, which always
return to the same basic problem: how can new data from biological
studies be used to design novel therapies for the treatment of
cardiac dysfunction following myocardial infarction, hypertension
and other disorders?
With its strong emphasis on translational research, this book
will appeal to both scientists and clinicians interested in
diminishing the impact of the current epidemic of cardiac
diseases.
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