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Oral Tolerance - Cellular and Molecular Basis, Clinical Aspects, and Therapeutic Potential (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Loot Price: R4,510
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Oral Tolerance - Cellular and Molecular Basis, Clinical Aspects, and Therapeutic Potential (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Series: Medical Intelligence Unit
Expected to ship within 10 - 15 working days
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Oral tolerance is a major immunological property of the
gastrointestinal mucosa. It plays a critical role in immune defence
by preventing inflammatory and allergic responses to dietary and
non pathogenic microbial antigens. The interest in oral tolerance
has been renewed in the recent years, due to novel insights on its
cellular mechanisms and potential clinical applications in the
treatment of autoimmune diseases. Oral Tolerance: Cellular and
Molecular Basis, Clinical Aspects, and Therapeutic Potential, has
been designed as a concise yet comprehensive overview of the newest
fundamental and clinical advances in the field. Based on the
outstanding contribution of world experts, this book will be
helpful to students, clinicians, and researchers working in mucosal
immunology and gastroenterology. The first part of this volume
describes the structure and functions of the gastrointestinal
mucosa and the fundamental features and mechanisms of oral
tolerance, including the role of T cells, cytokines, IgA
antibodies, and bacterial antigens. The second part explores the
clinical implications of the disruption of oral tolerance in
Inflammatory Bowel Diseases, food and milk allergies, and coeliac
disease in particular. The final chapter focuses on the clinical
potential of oral tolerance as a promising therapeutic tool.
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