Progestins play a key role in reproductive endocrinology and as
pharmaceutical drugs for contraception and in combined hormone
therapy. To further our understanding of progestin action in the
mammary gland, an international symposium, attended by leading
researchers from academia and industry, was held in Berlin, 21 23
March 2007. Genetic mouse models helped to elucidate the role of
progestins, both in normal breast development and in disease.
Mechanistic molecular studies inspired the design of new progestins
with improved tissue selectivity. In addition, the clinical impact
of progesterone receptor agonists and antagonists for the
prevention and treatment of breast cancer was discussed.
General
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