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Pharmaceutical Salts 2e - Properties, Selection and Use (Hardcover, 2nd Revised Edition)
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Pharmaceutical Salts 2e - Properties, Selection and Use (Hardcover, 2nd Revised Edition)
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The first edition of this handbook was a tremendous success,
collating the scientific literature on this topic that had
otherwise been rather limited and scattered throughout numerous
journals and patents. The result was a comprehensive resource that
addresses the preparation, selection, and use of pharmaceutically
active salts, examining the opportunities for increased efficacy
and improved drug delivery provided by the selection of an optimal
salt. This second, revised edition is designed to meet the
continued interest in both the topic and the book.
Altogether, the contributions to this book by international team of
authors from academia and pharmaceutical industry reflect the
multidisciplinary nature of the science involved in selection of
suitable salt forms for new drug products. They present the
necessary theoretical foundations as well as a wealth of detailed
practical experience in the choice of pharmaceutically active
salts, taking great care to address every conceivable aspect of the
preparation of pharmaceutical salts.
An introductory chapter presents a concise review of the various
objectives in the pursuit of pharmaceutically active salts,
followed by the theoretical background of salt formation. There
then follow chapters on the practice of salt formation in an
industrial R&D environment, as well as regulatory and patent
issues. Practical examples for the practitioners at the lab bench
are provided, before the book concludes with a comprehensive
annotated compilation of the individual salt-forming acids and
bases with their relevant properties, followed by an appendix
containing tables with the acids and bases sorted alphabetically
and by pKa, supplemented with other useful facts and data.
An essential reference for students of medicinal and pharmaceutical
chemistry, and an indispensable handbook for R&D chemists,
analytical chemists, biologists, development pharmacists,
regulatory and patent specialists, and medicinal scientists engaged
in preclinical development of drugs. In addition, this
comprehensive and up-to-date guide is an instructive companion for
all scientists involved in the research and development of drugs
and, in particular, of pharmaceutical dosage forms.
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