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Benzothiazole - A Biologically Important Scaffold (Paperback)
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Benzothiazole - A Biologically Important Scaffold (Paperback)
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Development in biological evaluation of heterocyclic molecules has
undergone manifold changes and the advancement in molecular biology
has eased the design of new molecules based on their mechanism of
action. Proposed work is based upon the development of newer
analogues of benzothiazoles followed by their biological
evaluation. Benzothiazoles have been reported with good biological
activities ranging from antiparasitic, anti-inflammatory,
antitumour, p56lck inhibition, immunosuppressive antitubercular
activity etc. The derivatives of benzothiazoles have been developed
very recently, targeting antitumour activity by various workers.
The type of molecules are reported to act based upon their
interaction with aryl hydrocarbon receptor as well as their
interaction with p56lck. Reports are available mentioning the
importance of metabolism and the deactivation of the molecules with
respect to their biopotency.This gives an additional avenue for the
researchers to work upon the concept of prodrug and mutual prodrugs
of these bioactive molecules and come up with better activity
profile. With this background, we thought to develop newer
analogues of the nucleus benzothiazole.
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