Liposomes as well as formulations based on drug-lipid complexes
have been extensively investigated for the delivery of a wide range
of pharmaceutical compounds. Commercial licensing of liposomal
dispersions for parenteral and topical use in humans has been
fairly recent and has occurred as a result of interdisciplinary
scientific advances in surface chemistry, membrane biophysics, and
molecular pharmacology. These developments were supported by
pioneering contributions from scientists in the fields of molecular
pharmaceutics, drug delivery, and chemical engineering. Thus, since
their original simplistic use as vesicular models for studying
membrane properties and transport, liposomal systems have evolved
into complex yet elegant assemblies for drug delivery. Liposomes
are now being developed with specific therapeutic roles for tissue
and cellular targeting and have been skillfully manipulated to
achieve desired clinical outcomes by altering in vivo drug
biodistribution and disposition. Liposomes are microscopic vesicles
composed of one or more lipid bilayers arranged in concentric
fashion enclosing an equal number of aqueous compartments.
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