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Receptor - Based Drug Design (Hardcover)
Loot Price: R5,217
Discovery Miles 52 170
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Receptor - Based Drug Design (Hardcover)
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Employing a wide range of examples from G-protein-coupled receptors
and ligand-gated ion channels, this detailed, single-source
reference illustrates the principles of pharmacological analysis
and receptor classification that are the basis of rational drug
design.
Explains the experimental and theoretical methods used to
characterize interactions between ligands and receptors-providing
the pharmacological information needed to solve treatment problems
and facilitate the drug design process
Demonstrating the achievements of the receptor-based approach in
therapeutics and indicating future directions, Receptor-Based Drug
Design
introduces novel computer-assisted strategies for the design of new
agonists, antagonists, and inverse agonists for G-protein-coupled
receptors
shows how to assess agonist concentration-effect curve data
discusses radioligand binding assays
presents new in vitro multiarray assays for G-protein-coupled
receptors
explains the use of individual second messenger signaling responses
in analyzing drug-receptor interactions
examines the role of electrophysiology in finding new drugs and
drug targets
describes selectively acting b-adrenoceptor agonists and
glucocorticoid steroids for asthma treatment
outlines the rationale for using angiotensin receptor antagonists
and more
Written by over 25 international authorities and containing nearly
1200 bibliographic citations, Receptor-Based Drug Design is a
practical resource for pharmacologists, pharmacists, and
pharmaceutical scientists; organic and medicinal chemists and
biochemists; molecular biologists; biomedical researchers; and
upper-level undergraduate and graduate students in these
disciplines.
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