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Statistical Methods for CGH Array Analysis (Paperback)
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Statistical Methods for CGH Array Analysis (Paperback)
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Genomic DNA copy number alterations are key genetic events in the
initiation and progression of human cancers. Recent advance in the
technique of microarray comparative genomic hybridization (array
CGH) enables one to screen genome-wide for all possible regions
with DNA copy number alterations, such as chromosome gains and
losses, or localized amplifications and deletions. In this book, we
introduce two statistical methods addressing two different
questions for the data analysis of array CGH. The first
method---Cluster Along Chromosomes--- is developed for calling
gains and losses in CGH arrays. The second method--- Boosted PRIM
(Patient Rule Induction Method)--- is developed to search for
oncogenic pathways using array-CGH data. The performance of the
methods are illustrated through both simulation studies and real
applications.
General
Imprint: |
VDM Verlag
|
Country of origin: |
Germany |
Release date: |
February 2010 |
First published: |
February 2010 |
Authors: |
Pei Wang
|
Dimensions: |
229 x 152 x 2mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
38 |
ISBN-13: |
978-3-639-11406-5 |
Categories: |
Books >
Science & Mathematics >
Mathematics >
Probability & statistics
|
LSN: |
3-639-11406-X |
Barcode: |
9783639114065 |
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