Flaviviruses are a diverse group of small RNA enveloped viruses,
many of which are important human and animal pathogens. The best
known include dengue virus, yellow fever virus, Japanese
encephalitis virus, and West Nile virus. These viruses are endemic
in many tropical and sub-tropical regions of the world. Dengue
virus alone infects over 100 million people annually. In recent
years, research on flaviviruses has progressed at a remarkable
rate, leading to significant advances in our understanding of virus
biology. This should ultimately lead to the development of better
vaccine and antiviral strategies. This up-to-date and cutting-edge
anthology contains contributions from the leading experts in the
flavivirus field. Chapters are balanced by contributions from
established investigators who have dedicated their careers to
flavivirus research with those from newcomers who have recently
made significant contributions to the flavivirus field. The book is
divided into two sections: Molecular Virology and Virus Prevention.
The first section on Molecular Virology covers: virion structure *
virus replication * the NS1 glycoprotein * the NS3 protein * the
NS5 protein * innate immunity and flavivirus infection * host
responses to flavivirus infection * flavivirus fitness and
transmission. The Virus Prevention section includes: vaccines *
antibody therapy * small molecule antiviral development *
flavivirus diagnostics * vector-virus interactions * vector
control. The book represents an important update of flavivirus
research and will serve as a reference to flavivirus researchers at
the graduate level and beyond. It is a recommended text for all
virology libraries.
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