The book presents state-of-the-art developments in multiscale
modeling and latest experimental data on multiscale mechanobiology
of bone remodeling and adaptation including fracture healing
applications. The multiscale models include musculoskeletal models
describing bone-muscle interactions during daily activities such as
walking or running, micromechanical models for estimation of bone
mechanical properties, bone remodeling and adaptation models,
cellular models describing the complex bone-cell interactions
taking into account biochemical and biomechanical regulatory
factors. Also subcellular processes are covered including
arrangement of actin filaments due to mechanical loading and change
of receptor configurations.
General
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