Carvedilol has unique pharmacological profile. It blocks 1, 2, and
1 receptors, used in the management of hypertension and as an
adjunct to standard therapy in symptomatic heart failure and also
produces vasodilation. In the present study, an attempt has been
made to improve drug concentration in the stomach by preparing
gastroretentive floating microsphere of carvedilol phosphate to
maintain drug levels within a desired range, reduce dosing
frequency, Improve patient compliance, improve dissolution and at
the site of absorption.Drug molecules presenting no difficulties in
their solubility and/or absorption problems are good candidates for
oral controlled release formulations but Obstacle may arise for
many drugs related to their solubility and/or absorption that may
be overcome by formulating Gastroretentive systems which prolong
the gastric retention time, improves solubility and hence improves
bioavailability for drugs that are less soluble in a high pH
environment.
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