Benzimidazole-2-Carboxylic Acids (Paperback)

Rheumatoid arthritis is progressive, autoimmune inflammatory chronic disorder which do not have curative treatment yet. Aryl and hetero-aryl acids has maximum share of anti-inflammatory drugs in the therapeutics today as non steroidal anti-inflammatory drugs (NSAIDs). Benzimidazole moiety with heteroaryl and psudoacedic nature is promising moiety for development of NSAIDs. In the present project, synthesis, pharmacological evaluation, probable mechanism of action and quantitative structure-activity relationship (QSAR) of benzmidazole-2-carboxylic acids are reported. The excellent efficacy and safety was observed for benzimidaxole-2-carboxylic acid derivatives in laboratory animal models of inflammation and rheumatoid arthritis without side-effect of gastrointestinal disturbances. The reliving effects against pain and fever in experimental animal models suggested promise as potential NSAID.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	July 2011
First published:	July 2011
Authors:	Prasad Thakurdesai • S.G. Wadodkar • C.T. Chopde
Dimensions:	229 x 152 x 7mm (L x W x T)
Format:	Paperback - Trade
Pages:	124
ISBN-13:	978-3-8433-7236-7
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	3-8433-7236-5
Barcode:	9783843372367

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