Pentazocine, which is known to act as an agonist at kappa opioid
receptors and a weak antagonist or a partial agonist at mu
receptors has shown significant anticonvulsant activity in MES test
and abolition of this anticonvulsant activity by high dose but not
by low dose of Naloxone. The present study was designed to compare
the anticonvulsant effect of Pentazocine with standard Sodium
Valproate in albino rats. An attempt was also made to determine the
possible opioid receptor mechanism involved.
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