Carcinoma breast is an ancient and elusive disease which has
claimed the lives of many, since time immemorial. It is one of the
most serious problems of clinical and research oncology and till
date, remains the commonest cause of death from cancer in women.
Despite extensive research that has been on-going for decades
throughout the world, the etiopathogenesis of breast cancer still
remains obscure. Various etiological factors have been proposed but
their relevance has not yet been elucidated. The main focus of this
research work has been to delve into the role of one of those risk
factors, i.e., oxidative stress in breast carcinogenesis. Oxidative
stress has been implicated in several human pathologies such as
cardiovascular diseases, neurological diseases and several
malignancies - just to name a few. The question we ask ourselves at
this stage is - "what are the implications of oxidative stress in
breast carcinogenesis?" If oxidative stress really is an important
causative factor of carcinoma breast, this would be a major
breakthrough in the search for a cure for breast cancer since
prevention of oxidative stress would be synonymous to prevention of
breast carcinogenesis.
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