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The CAPRISA Clinical Trials: HIV Treatment and Prevention (Hardcover, 1st ed. 2017)
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The CAPRISA Clinical Trials: HIV Treatment and Prevention (Hardcover, 1st ed. 2017)
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Since its inception 14 years ago, CAPRISA has conducted numerous
clinical studies that have influenced international TB-HIV
treatment guidelines as well as HIV prevention through innovations
in the microbicide and vaccine fields. This book provides a
historical account of how each of CAPRISA's high impact studies was
created, developed, implemented, analysed and communicated. In
doing so, the reader is taken on a journey that provides glimpses
into the genesis of research ideas and how this ultimately leads to
a range of HIV prevention and treatment studies that have impacted
the global response to the HIV and TB epidemics. Comprised of 5
sections, the book details the following: HIV epidemic in South
Africa and the establishment of a research centre to undertake
clinical, epidemiological and laboratory research on HIV. CAPRISA's
clinical trials on HIV and HSV-2 prevention. These studies
investigated the impact of tenofovir gel as topical antiretroviral
pre-exposure prophylaxis (PrEP), implementation of topical PrEP
through family planning clinics, conditional cash incentives for
HIV prevention, HIV vaccines, and passive immunisation with broadly
neutralising antibodies. CAPRISA's research on the treatment of HIV
and TB co-infection. A review of the major scientific findings from
the CAPRISA studies on acute infection and genital mucosal
immunology. Essential support activities for the conduct of
clinical trials, including research laboratories and pharmacies, as
well as establishing effective communication and sustainable
structures for community engagement to maintain effective and
respectful partnerships with participating communities. The book
concludes with a chapter about the challenges facing future HIV
prevention and treatment trials. The CAPRISA Clinical Trials: HIV
Treatment and Prevention is a resource for undergraduate and
postgraduate students, health care providers, doctors,
decision-makers and researchers who are seeking guidance and
insights on clinical trials - their creation, conduct and impact.
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