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Advances in Fertility Control and the Treatment of Sterility - The Proceedings of a Special Symposium held at the XIth World Congress on Fertility and Sterility, Dublin, June 1983 (Paperback, Softcover reprint of the original 1st ed. 1984)
Loot Price: R2,875
Discovery Miles 28 750
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Advances in Fertility Control and the Treatment of Sterility - The Proceedings of a Special Symposium held at the XIth World Congress on Fertility and Sterility, Dublin, June 1983 (Paperback, Softcover reprint of the original 1st ed. 1984)
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Since human prolactin was isolated and characterized 13 years ago,
the study of the control of prolactin secretion has been intensive.
Hyperprolactinaemia is the most commonly identifiable hypothal-
amic pituitary disorder1,2. The dominant inhibitory nature of hypo-
thalamic control of prolactin secretion may be the reason that
hyperprolactinaemia is such a common condition. During the PClst
decade two separate therapeutic approaches to the management of
hyperprolactinaemia have been introduced: transsphenoidal selec-
tive pituitary microsurgery and medical therapy to suppress
prolactin secretion with orally active long-acting dopamine agonist
drugs. Small prolactin-secreting tumours are treated extremely
satisfactorily both with medical and with surgical therapy, both in
terms of lower- ing serum prolactin levels to normal and in
restoring gonadal func- tion. However, for the larger tumours,
either where the tumour is invasive or the pretreatment serum
prolactin level is greater than 1 250ngml- the results of surgery
are poor in terms of restoring to normal circulating prolactin
levels and gonadal functionJ-s. We now discuss the medical
management of hyperprolactinaemia, potential problems during
pregnancy and the management of large prolactin- secreting
pituitary tumours.
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