The objective of this study is to develop controlled porosity
osmotic pump tablet of Verapamil Hydrochloride, which is an
antihypertensive candidate, using Polyethylene glycol (PEG) 400 as
pore former in Cellulose acetate semipermeable membrane and
Mannitol as a osmotic agent which release drug for extended period
of time (24 h) and drug release of optimized formulation is
independent of pH and agitation speed with zero order release.
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