The analysis of drugs and their metabolites in biological media
are now expected to routinely achieve 20% accuracy in the ng/mL
concentration level. Therefore, the availability and the selection
of quality ion-pairs designating the analytes and their
isotopically labeled analogs (ILAs) are important considerations in
achieving the accuracy of quantitation results. Assisting
scientists with this process, Quantitation and Mass Spectrometric
Data of Drugs and Isotopically Labeled Analogs provides an
extremely valuable reference for labs involved in the analysis of
therapeutic and abused drugs.
Part One of this comprehensive volume illustrates approaches,
mechanisms, and challenges pertaining to the use of isotopic
analogs as internal standards for drug quantitation. The second
section is a systematic compilation of full-scan mass spectra of
drugs and their analogs, as parent compounds and as derivatives
resulting from various chemical derivatization approaches, commonly
encountered in today s labs. Based on the mass spectra data
presented in the second section, Part Three provides corresponding
tables of ion-pairs which can potentially be adapted to designate
the drugs and their isotopic analogs in the analytical processes.
Relative quality of these ion-pairs (cross-contribution to the
intensity of these ions by their isotopic analogs) is included in
these tables.
With more than 1500 full-scan mass spectra and quick access data
tables, this text represents the authors years of work compiling
mass spectra of the many chemical derivatization forms of drugs,
their metabolites, and their isotopically labeled counterparts. The
unparalleled scope of this compilation makes it a critical one-stop
reference for those involved in drug analyses of biological
specimens and interpretation of results.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!