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Floating Microspheres - An Intelligent Drug Delivery System (Paperback)
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Floating Microspheres - An Intelligent Drug Delivery System (Paperback)
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This book initially provides a review of floating drug delivery
systems. This system has a bulk density lower than the gastric
content. They remain buoyant in the stomach for a prolonged period
of time, with the potential for continuous release of drug. Gastric
emptying is much more rapid in the fasting state and floating
systems really heavily on the presence of food to retard emptying
and provide sufficient liquid for effective buoyancy. When
microspheres come in contact with gastric fluid the gel formers,
polysaccharides, and polymers hydrate to form a colloidal gel
barrier that controls the rate of fluid penetration into the device
and consequent drug release. The air trapped by the swollen polymer
lowers the density and confers buoyancy to the microspheres.
However a minimal gastric content needed to allow proper
achievement of buoyancy. Hollow microspheres of Acrylic resins 57,
Eudragit, PMAA, floating granules are the recent developments in
this field. The book then presents studies conducted on producing
microspheres containing Antidiabetic drug. The book also discusses
various formulation and processing parameters and in-vivo study in
wistar rats.
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