This book brings together a number of studies which examine the
ways in which the retention and selectivity of separations in
high-performance liquid chromatography are dependent on the
chemical structure of the analytes and the properties of the
stationary and mobile phases. Although previous authors have
described the optimisation of separations by alteration of the
mobile phase, little emphasis has previously been reported of the
influence of the structure and properties of the analyte.
The initial chapters describe methods based on retention index
group increments and log P increments for the prediction of the
retention of analytes and the ways in which these factors are
influenced by mobile phases and intramolecular interactions. The
values of a wide range of group increments in different eluents are
tabulated.
Different scales of retention indices in liquid chromatography
are described for the comparison of separations, the identification
of analytes and the comparison of stationary phases. Applications
of these methods in the pharmaceutical, toxicology, forensic,
metabolism, environmental, food and other fields are reviewed. The
effects of different mobile phases on the selectivity of the
retention indices are reported. A compilation of sources of
reported retention index values are given.
Methods for the comparison of stationary phases based on the
interactions of different analytes are covered, including
lipophilic and polar indices, shape selectivity comparisons, their
application to novel stationary phases, and chemometric methods for
column comparisons.
General
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