It is estimated that 80 to 90% of drugs under development never
make it to the marketplace due to insufficient clinical activity,
unacceptable toxicity, rapid appearance of drug resistance, or
other factors that should be, at least partially, predictable from
preclinical testing. This new text asks the question, "How can we
use computational methods to improve the success rate in drug
development?" Computer Techniques in Preclinical and Clinical Drug
Development shows how modeling makes it possible to extract the
maximum amount of information and predictive value from preclinical
data. Computer modeling methods from the areas of pharmacokinetics,
pharmacodynamics, cytokinetics, and inhibition kinetics of
multi-enzyme pathways are all discussed in this unique reference
source.
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