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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Development and Application of Biomarkers (Paperback)
Loot Price: R2,376
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Development and Application of Biomarkers (Paperback)
Series: Protein Science
Expected to ship within 12 - 19 working days
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First introduced to biomedical research in 1980, the term biomarker
has taken on a life of its own in recent years and has come to mean
a number of things. In biomedical science, biomarker has evolved to
most commonly mean a characteristic that can be used either as a
diagnostic or a prognostic, but most significantly as a screening
indicator for pathologies that tend to be somewhat silent prior to
overt clinical display. Applying scientific rigor, as well as a
disciplined approach to nomenclature, Roger Lundblad's Development
and Application of Biomarkers rationalizes the current enthusiasm
for biomarkers with the use of well-established clinical laboratory
analytes in clinical medicine. Highly respected for his work as
both a classical protein scientist and as a pioneer in proteomics,
Dr. Lundblad catalogs various biomarkers recognized in clinical
medicine and, where possible, matches the expectations for advances
in screening technologies with the realities of statistical
analysis. More specifically, this important reference: Details an
extensive list of biomarkers for various stages of a number of
cancer types including ovarian, pancreatic, prostate, and breast
cancer Looks at how proteomics is used for the discovery and
validation of biomarkers Explores the use of microarray technology,
ultra-high performance liquid chromatography, and computational
bioinformatic approaches for the discovery and use of biomarkers
Examines the use of cells and cell fragments as more complex
biomarkers Organizes a host of significant biomarkers and essential
research by type and use in a series of readily accessible tables
Throughout this volume, Dr. Lundblad encourages consideration of
biomarkers more as a concept than as laboratory analytes,
emphasizing the relation between the discovery of a biomarker and
the biology underlying its production. Ultimately, it is a thorough
understanding of that underlying biology that will lead to the
development of assays that are robust and reproducible, as well as
clinically significant.
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