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Non-canonical Cyclic Nucleotides (Hardcover, 1st ed. 2017)
Loot Price: R9,217
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Non-canonical Cyclic Nucleotides (Hardcover, 1st ed. 2017)
Series: Handbook of Experimental Pharmacology, 238
Expected to ship within 10 - 15 working days
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The cyclic purine nucleotides 3',5'-cAMP and 3',5'-cGMP are
well-established second messengers. cGMP has recently been covered
in a volume of the Handbook of Experimental Pharmacology (volume
191). In addition to 3',5'-cAMP and 3',5'-cGMP, so-called
non-canonical cyclic nucleotides exist. These comprise the cyclic
pyrimidine nucleotides 3',5'-cCMP and 3',5'-cUMP, the purine
nucleotide 3',5'-cIMP, the 2',3'-nucleoside monophosphates and
cyclic dinucleotides. In this volume of the Handbook of
Pharmacology, word-leading experts in the field summarize our
current knowledge on these non-canonical cyclic nucleotides,
discuss open questions, future research directions and the
pharmacotherapeutic implications. Special emphasis will be given to
the emerging roles of 3',5'-cCMP and 3',5'-cUMP as second
messengers with regard to generators, effectors, biological
functions, inactivation and bacterial toxins. The role of
3',5'-cIMP as potential second messenger will also be critically
discussed. Furthermore, we will consider transport of cyclic
nucleotides and their potential role as first messengers. The role
of the cyclic dinucleotide cGAMP in the immune system will covered,
too. Lastly, the book will present important methodological aspects
ranging from mass-spectrometric methods for cyclic nucleotide
detection to the synthesis of nucleotide analogs as experimental
tools and holistic methods for analysis of cyclic nucleotide
effects.
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