Molecular Neurosurgery with Targeted Toxins (Hardcover, 2005 ed.)

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

General

Imprint:	HumanaPress
Country of origin:	United States
Release date:	March 2005
First published:	2005
Editors:	Ronald G. Wiley • Douglas A. Lappi
Dimensions:	235 x 155 x 21mm (L x W x T)
Format:	Hardcover
Pages:	312
Edition:	2005 ed.
ISBN-13:	978-1-58829-199-8
Categories:	Books > Medicine > Surgery > Neurosurgery Promotions
LSN:	1-58829-199-5
Barcode:	9781588291998

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