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Effect of Cigarette Smoke on the Pharmacokinetics of Ofloxacin (Paperback)
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Effect of Cigarette Smoke on the Pharmacokinetics of Ofloxacin (Paperback)
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The thousands of chemicals besides the soot of the cigarette
inhaled for decades keep on acting on the various tissues and body
systems causing changes in them ultimately leading to the
irreparable damages system to function normally. Smoking can induce
alteration in drug absorption, metabolism, degeneration,
detoxification and drug excretion either in original form or in
altered simple compound form. Therefore our aim was to investigate
the effect of cigarette smoke on the pharmacokinetic profile of
ofloxacin by using rabbits as experimental model. The tested group
animals were exposed to cigarette smoke twice daily for 60 days.
Ofloxacin was administered orally and samples of blood plasma were
collected from each animal at different time intervals. Ofloxacin
concentration in plasma samples is determined by microbiological
assay using agar well diffusion method. Staphylococcus aureus was
used as test organism. During the study on the drug interaction of
cigarette smoke with ofloxacin, the pharmacokinetic parameters of
ofloxacin such as AUC, Cmax, Tmax, t1/2, Vd and CL were altered due
to the effect of cigarette smoke.
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