Immunomodulation using medicinal plants can provide an alternative
to conventional chemotherapy for a variety of diseases especially
when host defense mechanism has to be acquired under the conditions
of impaired immune responsiveness. The objective of the present
study was to investigate the immunomodulatory potential of aqueous
extract of Trapa bispinosa (TBAE) in immunodeficient experimental
animals by studying humoral immunity response, delayed type
hypersensitivity reaction, macrophase phagocytosis and percent
change in neutrophil counts. Further to evaluate antistress
activity, wistar rats were subjected to forced swimming endurance
test and chronic cold restraint stress. The result of present study
suggests that ethanolic fraction of TBAE could stimulate the
cellular and humoral response in animals. The anti-stress and
adaptogenic activity exhibited by its ethanol fraction in the study
further suggests that its ethanolic fraction may useful in the
treatment of several disorders caused by stress by its
immunostimulating and immunomodulating properties and also
enhancing the homeostasis mechanism.
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